公开(公告)号：US08580749B2

公开(公告)日：2013-11-12

申请号：US12795195

申请日：2010-06-07

Applicant: Joseph Wagner ,  Randell Young ,  David Fink

Inventor： Joseph Wagner ,  Randell Young ,  David Fink

IPC: A61K38/08

CPC classification number: A61K35/28 ,  A61K47/543 ,  A61K47/64

Abstract: Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

Abstract translation: 本发明的实施方案涉及包含治疗细胞和涂覆治疗细胞的多种靶向复合物的涂覆细胞，并且每种所述靶向复合物包含归巢分子，脂质部分和具有约1至约10个 氨基酸，并将归巢分子与脂质部分共价连接，并且其中脂质部分非共价连接到治疗细胞上。 在一些实施方案中，治疗细胞是干细胞。 本发明的实施方案涉及涂覆治疗细胞的方法。 本发明的实施方案涉及治疗脉管系统疾病的方法。

公开(公告)号：US20100310531A1

公开(公告)日：2010-12-09

申请号：US12795195

申请日：2010-06-07

Applicant: Joseph Wagner ,  Randell Young ,  David Fink

Inventor： Joseph Wagner ,  Randell Young ,  David Fink

IPC: A61K35/12 ,  C07K7/06 ,  C12N5/0789 ,  C07K7/08 ,  C12N5/074 ,  C12N5/0775 ,  A61P9/00

CPC classification number: A61K35/28 ,  A61K47/543 ,  A61K47/64

Abstract: Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

Abstract translation: 本发明的实施方案涉及包含治疗细胞和涂覆治疗细胞的多种靶向复合物的涂覆细胞，并且每种所述靶向复合物包含归巢分子，脂质部分和具有约1至约10个 氨基酸，并将归巢分子与脂质部分共价连接，并且其中脂质部分非共价连接到治疗细胞上。 在一些实施方案中，治疗性细胞是干细胞。 本发明的实施方案涉及涂覆治疗细胞的方法。 本发明的实施方案涉及治疗脉管系统疾病的方法。