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公开(公告)号：US20240245294A1
公开(公告)日：2024-07-25
申请号：US18494617
申请日：2023-10-25
申请人： GLAUKOS CORPORATION
发明人： Charles Raymond Kalina, JR. , Thomas W. Burns , Chris Calcaterra , Edward Collins , Timothy McCauley , David S. Haffner , Steven M. Henderson
CPC分类号： A61B3/117 , A61B3/0033 , A61B3/0083
摘要： A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.
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公开(公告)号：US11872213B2
公开(公告)日：2024-01-16
申请号：US17587510
申请日：2022-01-28
申请人： Glaukos Corporation
IPC分类号： A61K31/4178 , A61K9/06 , A61K9/00 , A61K47/02 , A61K47/12 , A61K38/13 , A61K31/46 , A61K31/498 , A61K31/56 , A61K31/27 , A61K31/5575
CPC分类号： A61K31/4178 , A61K9/0048 , A61K9/06 , A61K31/27 , A61K31/46 , A61K31/498 , A61K31/5575 , A61K31/56 , A61K38/13 , A61K47/02 , A61K47/12
摘要： Described herein are formulations including pharmaceutical agents comprising ester and/or lactone ring structures, and methods of using the same. The invention is also directed to a method and ophthalmic pharmaceutical compositions including solution and semisolid dosage forms (i.e. ophthalmic creams, gels, lotions, serums, and/or ointments) of treating a patient with various ocular diseases including presbyopia and dry eyes. The method comprising instructing a patient to apply one strip of the ophthalmic composition to the eyelids that includes pilocarpine or other active pharmaceutical ingredients containing ester and/or lactone ring structures with and without the buffering system.
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公开(公告)号：US20230329571A1
公开(公告)日：2023-10-19
申请号：US18339820
申请日：2023-06-22
申请人： GLAUKOS CORPORATION
CPC分类号： A61B5/03 , A61B5/6821 , A61B5/0002 , A61B5/14532 , A61B5/6882 , A61B2562/0214 , A61B2562/0247
摘要： Intraocular physiological sensor implants include a physiological sensor, and a housing comprising a faceplate. The physiological sensor is integrated with the faceplate. The physiological sensor typically comprises an intraocular pressure sensor, such as a capacitive pressure sensor that may further include a flexible diaphragm electrode spaced apart from a counter electrode. The intraocular pressure sensor detects intraocular pressure, to identify patient conditions such as glaucoma.
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公开(公告)号：US20230301830A1
公开(公告)日：2023-09-28
申请号：US18310109
申请日：2023-05-01
申请人： GLAUKOS CORPORATION
发明人： Harold Heitzmann , Vanessa Tasso
CPC分类号： A61F9/0017 , A61K9/0051 , A61M31/002 , A61K9/2072 , A61M2205/0266 , A61M2210/0612 , A61M2205/04 , A61F2220/00 , A61F2250/0068 , A61F2210/0004
摘要： Disclosed herein are drug delivery ocular implants comprising an elongate outer shell having a proximal end, and distal end and being shaped to define an interior lumen, at least one therepautic agent positioned within the lumen, wherein the outer shell has at least a first thickness, the outer shell comprises one or more regions of drug release, and the implant is dimensioned for implantation within the anterior chamber of the eye.
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公开(公告)号：US20230293344A1
公开(公告)日：2023-09-21
申请号：US18158705
申请日：2023-01-24
申请人： GLAUKOS CORPORATION
CPC分类号： A61F9/0017 , A61F9/00772 , A61K31/56 , A61K31/573 , A61K31/58 , A61K38/13 , A61F2210/0004 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2250/0068
摘要： Disclosed herein are drug delivery punctal implants and methods of using the implants for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The physical arrangement of drugs within the punctal plugs disclosed herein results, in several embodiments, in advantageous controlled delivery of one or more drugs to the eye of a patient.
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公开(公告)号：US11564833B2
公开(公告)日：2023-01-31
申请号：US15762969
申请日：2016-09-23
申请人： GLAUKOS CORPORATION
摘要： Disclosed herein are drug delivery punctal implants and methods of using the implants for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The physical arrangement of drugs within the punctal plugs disclosed herein results, in several embodiments, in advantageous controlled delivery of one or more drugs to the eye of a patient.
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公开(公告)号：US20210315806A1
公开(公告)日：2021-10-14
申请号：US17214471
申请日：2021-03-26
申请人： GLAUKOS CORPORATION
发明人： David S. Haffner
摘要： Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
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公开(公告)号：US11019996B2
公开(公告)日：2021-06-01
申请号：US16706525
申请日：2019-12-06
申请人： GLAUKOS CORPORATION
发明人： Charles Raymond Kalina, Jr. , Thomas W. Burns , Chris Calcaterra , Edward Collins , Timothy McCauley , David S. Haffner , Steven M. Henderson
摘要： A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.
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公开(公告)号：US10849558B2
公开(公告)日：2020-12-01
申请号：US15668428
申请日：2017-08-03
申请人： GLAUKOS CORPORATION
摘要： An implantable intraocular physiological sensor for measuring a physiological characteristic, such as intraocular pressure. The implantable intraocular physiological sensor may include a tubular main body configured to house one or more electrical components. The implantable intraocular physiological sensor may also include a sensor cap configured to be inserted into a first end of the tubular main body with a moisture barrier seal. The implantable intraocular physiological sensor may wirelessly transmit measurements to an external device.
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