公开(公告)号：US12097308B2

公开(公告)日：2024-09-24

申请号：US16642822

申请日：2018-06-19

Applicant: KNU—Industry Cooperation Foundation

Inventor： Kwang Ho Lee

IPC: A61L31/14 ,  A61B5/053 ,  A61L31/04 ,  A61L31/08 ,  A61L31/10 ,  B29C64/106 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C08J7/04 ,  C08J7/044 ,  D01D5/00 ,  B29K83/00 ,  B82Y30/00

CPC classification number: A61L31/146 ,  A61B5/053 ,  A61L31/041 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  B29C64/106 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C08J7/0423 ,  C08J7/044 ,  D01D5/003 ,  A61B2562/0214 ,  A61B2562/125 ,  A61L2420/02 ,  A61L2420/08 ,  B29K2083/00 ,  B82Y30/00 ,  C08J2383/04 ,  C08J2475/04 ,  D10B2331/10 ,  A61L31/10 ,  C08L75/04

Abstract: The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.

公开(公告)号：US12082929B2

公开(公告)日：2024-09-10

申请号：US17135766

申请日：2020-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M2005/1726

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US12053634B2

公开(公告)日：2024-08-06

申请号：US17732716

申请日：2022-04-29

Applicant: Autonomix Medical, Inc.

Inventor： Landy Toth ,  Robert Schwartz

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/24 ,  A61B5/283 ,  A61B5/296 ,  A61B7/04 ,  A61B18/14 ,  A61M5/14 ,  A61N1/05 ,  A61N1/372 ,  A61B10/02 ,  A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61N7/02

CPC classification number: A61N1/37205 ,  A61B5/02007 ,  A61B5/0205 ,  A61B5/1107 ,  A61B5/24 ,  A61B5/283 ,  A61B5/296 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/4875 ,  A61B5/6852 ,  A61B7/04 ,  A61B18/1445 ,  A61B18/1492 ,  A61M5/14 ,  A61N1/05 ,  A61B10/02 ,  A61B2017/00345 ,  A61B2018/00291 ,  A61B2018/00345 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00755 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B18/02 ,  A61B2018/143 ,  A61B2562/0214 ,  A61M2202/0275 ,  A61M2202/048 ,  A61M2202/0484 ,  A61M2202/049 ,  A61N1/0553 ,  A61N1/0556 ,  A61N7/02

Abstract: A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure is disclosed.

公开(公告)号：US20240245312A1

公开(公告)日：2024-07-25

申请号：US18604009

申请日：2024-03-13

Applicant: Trustees of Tufts College ,  Massachusetts Institute of Technology

Inventor： Mandayam A. SRINIVASAN ,  Mohan Thanikachalam ,  Edward Howard Adelson ,  Abhijit Biswas

IPC: A61B5/022 ,  A61B5/02 ,  A61B5/107 ,  A61B8/08

CPC classification number: A61B5/02233 ,  A61B5/02007 ,  A61B5/1075 ,  A61B5/1079 ,  A61B8/0891 ,  A61B2560/0223 ,  A61B2562/0214 ,  A61B2562/04

Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

公开(公告)号：US20240099646A1

公开(公告)日：2024-03-28

申请号：US18275629

申请日：2022-02-11

Applicant: MEDICA S.P.A. ,  SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA

Inventor： Marcello Chiurazzi ,  Giorgia Spraeafico ,  Andrea Firrincieli ,  Gastone Ciuti ,  Cesare Stefanini ,  Francesco Paolo Falotico ,  Davide Bagnoli ,  Sergio Emiliani

IPC: A61B5/00

CPC classification number: A61B5/4233 ,  A61B5/6847 ,  A61B2562/0214 ,  A61B2562/12 ,  A61B2562/164 ,  A61B2562/182

Abstract: A method for the production of a diagnostic device comprising the steps of: obtaining a blank from a plastic material sheet; the blank comprising one or more support bands provided with electrical tracks; providing one or more sensitive elements, in particular detection pads, for each band, being configured to generate signals, in particular pressure signals and being connected to the electrical tracks for the transmission of signals; applying a first electrically conductive coating on the blank in the area of the sensitive elements; creating a main structure from the blank, in particular by rolling the blank, keeping the first electrically conductive coating radially on the inside of the main structure; and creating an auxiliary matrix which wraps the main structure and fills the gaps between the support bands, so as to obtain a tubular body.

公开(公告)号：US11918381B2

公开(公告)日：2024-03-05

申请号：US17855440

申请日：2022-06-30

Applicant: Apple Inc.

Inventor： Shahrooz Shahparnia ,  Erno H. Klaassen

IPC: A61B5/01 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/053 ,  A61B5/113 ,  A61B5/282 ,  A61B5/327 ,  A61B5/08 ,  A61B5/103 ,  A61B5/11

CPC classification number: A61B5/6892 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/02444 ,  A61B5/053 ,  A61B5/113 ,  A61B5/282 ,  A61B5/327 ,  A61B5/4815 ,  A61B5/7278 ,  A61B5/02405 ,  A61B5/02438 ,  A61B5/0816 ,  A61B5/1036 ,  A61B5/1102 ,  A61B5/1126 ,  A61B5/6843 ,  A61B2560/0242 ,  A61B2560/0252 ,  A61B2562/0214 ,  A61B2562/0247 ,  A61B2562/046

Abstract: This relates to a monitoring system capable of measuring a plurality of vital signs. The monitoring system can include a plurality of sensors including, but not limited to, electrodes, piezoelectric sensors, temperature sensors, and accelerometers. The monitoring system can be capable of operating in one or more operation modes such as, for example: capacitance measurement mode, electrical measurement mode, piezoelectric measurement mode, temperature measurement mode, acceleration measurement mode, impedance measurement mode, and standby mode. Based on the measured values, the monitoring system can analyze the user's sleep, provide feedback and suggestions to the user, and/or can adjust or control the environmental conditions to improve the user's sleep. The monitoring system can further be capable of analyzing the sleep of the user(s) without directly contacting or attaching uncomfortable probes to the user(s) and without having to analyze the sleep in an unknown environment (e.g., a medical facility).

公开(公告)号：US20240049994A1

公开(公告)日：2024-02-15

申请号：US18264755

申请日：2022-02-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Lu Yin ,  Hazhir Teymourian ,  Joseph Wang ,  Juliane R. Sempionatto-Moreto ,  Jong-Min Moon

IPC: A61B5/145

CPC classification number: A61B5/14517 ,  A61B5/14546 ,  A61B2562/0214

Abstract: Methods, systems, and devices are disclosed for collecting and transferring naturally-produced sweat containing an analyte to a biosensor and/or biofuel cell to estimate a concentration of the analyte corresponding to the analyte's concentration in blood and/or for producing electricity. In some aspects, a device includes a substrate, a plurality of electrodes disposed on the substrate and operable to detect an analyte in naturally-produced sweat of an individual, and a sweat permeation layer including a hydrogel, wherein the sweat permeation layer is in contact with the plurality of electrodes and configured to transfer the sweat containing the analyte through the sweat permeation layer to reach the plurality of electrodes for detection and/or energy harvesting.

公开(公告)号：US11896308B2

公开(公告)日：2024-02-13

申请号：US18064422

申请日：2022-12-12

Applicant: ACUCELA INC.

Inventor： Christian Oggenfuss ,  Karim Haroud ,  Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota ,  Philip Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/1005 ,  A61B3/132 ,  A61B2560/0431 ,  A61B2562/0214 ,  A61B2562/0257 ,  A61B2562/223

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US11813064B2

公开(公告)日：2023-11-14

申请号：US16136522

申请日：2018-09-20

Applicant: Nokia Technologies Oy

Inventor： Kim Blomqvist ,  Satu Rajala

IPC: A61B5/11 ,  A61B5/25 ,  A61B5/30 ,  A61B5/291 ,  A61B5/113 ,  A61B5/00 ,  A61B5/0531 ,  A61B5/259 ,  A61B5/302 ,  A61B5/316 ,  A61B5/389 ,  A61B5/024 ,  A61B5/0533

CPC classification number: A61B5/30 ,  A61B5/1102 ,  A61B5/113 ,  A61B5/25 ,  A61B5/291 ,  A61B5/6801 ,  A61B5/02405 ,  A61B5/0531 ,  A61B5/0533 ,  A61B5/259 ,  A61B5/302 ,  A61B5/316 ,  A61B5/389 ,  A61B5/7225 ,  A61B2562/0214 ,  A61B2562/164

Abstract: An apparatus and electronic circuitry wherein the apparatus includes a first electrode arranged to enable an output indicative of a bioelectrical signal to be provided; a second electrode; and a deformable material positioned between the first electrode and the second electrode wherein the deformable material is positioned within the apparatus such that deformation of the deformable material causes a change in charge distribution across the first electrode and second electrode to enable an output indicative of a biomechanical signal to be provided by the apparatus.

公开(公告)号：US11779265B2

公开(公告)日：2023-10-10

申请号：US16440687

申请日：2019-06-13

Applicant: BRUIN BIOMETRICS, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Majid Sarrafzadeh ,  William Kaiser ,  Alireza Mehrnia ,  Barbara M. Bates-Jensen ,  Frank Wang ,  Michael Flesch ,  Joseph Boystak ,  Yeung Lam

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/0533 ,  A61B5/0537

CPC classification number: A61B5/447 ,  A61B5/05 ,  A61B5/0533 ,  A61B5/0537 ,  A61B5/443 ,  A61B5/445 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/7271 ,  A61B5/7285 ,  A61B2562/0214 ,  A61B2562/0247 ,  A61B2562/04 ,  A61B2562/046 ,  A61B2562/066 ,  A61B2562/164

Abstract: A handheld, conforming capacitive sensing apparatus configured to measure Sub-Epidermal Moisture (SEM) as a mean to detect and monitor the formation of pressure ulcers. The device incorporates an array of electrodes which are excited to measure and scan SEM in a programmable and multiplexed manner by a battery-less RF-powered chip. The scanning operation is initiated by an interrogator which excites a coil embedded in the apparatus and provides the needed energy burst to support the scanning/reading operation. Each electrode measures the equivalent sub-epidermal capacitance corresponding and representing the moisture content.