公开(公告)号：US10028965B2

公开(公告)日：2018-07-24

申请号：US14893381

申请日：2014-05-23

申请人： Icon Bioscience, Inc.

发明人： Vernon G. Wong ,  William S. White ,  Mae W. Hu ,  Glenn T. Huang ,  Faina Karasina

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K47/14

摘要： The present embodiments provide for a treatment regimen and use of a short-term sustained release liquid formulation of dexamethasone in citrate, wherein a single administration of a minute dosage form into the anterior chamber of the eye provides for anti-inflammatory therapy following cataract surgery.

公开(公告)号：US10022502B2

公开(公告)日：2018-07-17

申请号：US14113803

申请日：2012-04-25

申请人： Vernon G. Wong ,  Tan Pham ,  William S. White ,  Glenn T. Huang ,  Mae W. Hu

发明人： Vernon G. Wong ,  Tan Pham ,  William S. White ,  Glenn T. Huang ,  Mae W. Hu

IPC分类号： A61M5/315

摘要： Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.

公开(公告)号：US20230078906A1

公开(公告)日：2023-03-16

申请号：US17948842

申请日：2022-09-20

申请人： ICON BIOSCIENCE, INC.

发明人： Vernon G. WONG ,  William S. WHITE ,  Mae W. HU ,  Glenn T. HUANG ,  Faina KARASINA

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K47/14

摘要： The present embodiments provide for a treatment regimen and use of a short-term sustained release liquid formulation of dexamethasone in citrate, wherein a single administration of a minute dosage form into the anterior chamber of the eye provides for anti-inflammatory therapy following cataract surgery.

公开(公告)号：US10799642B2

公开(公告)日：2020-10-13

申请号：US16012497

申请日：2018-06-19

申请人： ICON BIOSCIENCE, INC.

发明人： Vernon G. Wong ,  Tan Pham ,  William S. White ,  Glenn T. Huang ,  Mae W. Hu

IPC分类号： A61M5/315

摘要： The present embodiments provide for simple devices that guide the loading and dispensing of accurate small doses of fluid from standard injection syringes.

公开(公告)号：US09283231B2

公开(公告)日：2016-03-15

申请号：US14168139

申请日：2014-01-30

申请人： Icon Bioscience, Inc.

发明人： Vernon G. Wong ,  Mae W. Hu ,  Glenn T. Huang

IPC分类号： A61K31/216 ,  A61K31/5575 ,  A61K9/00 ,  A61K47/14

CPC分类号： A61K31/5575 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/14

摘要： The present embodiments provide for methods of treating elevated intraocular pressure or glaucoma using a sustained release medicament consisting of prostaglandin in benzyl benzoate that is injected intraocularly no more frequently than once every two months.

摘要翻译： 本实施例提供了使用由前列腺素组成的持续释放药物治疗眼内压或青光眼的方法，所述缓释药物由苯甲酸苄酯组成，其眼内注射的频率不得超过每两个月一次。

公开(公告)号：US20140180245A1

公开(公告)日：2014-06-26

申请号：US14113803

申请日：2012-04-25

申请人： Vernon G. Wong ,  Tan Pham ,  William S. White ,  Glenn T. Huang ,  Mae W. Hu

发明人： Vernon G. Wong ,  Tan Pham ,  William S. White ,  Glenn T. Huang ,  Mae W. Hu

IPC分类号： A61M5/315

CPC分类号： A61M5/31536 ,  A61M5/315 ,  A61M5/3156 ,  A61M5/31591

摘要： Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.

摘要翻译： 公开了引导从注射器精确加载和分配预定剂量的流体的装置。

公开(公告)号：US20140140992A1

公开(公告)日：2014-05-22

申请号：US14124631

申请日：2012-06-11

申请人： Vernon G. Wong ,  Louis L. Wood ,  Glenn T. Huang

发明人： Vernon G. Wong ,  Louis L. Wood ,  Glenn T. Huang

IPC分类号： A61K47/34 ,  A61K39/395 ,  A61K38/17

CPC分类号： A61K39/39541 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/08 ,  A61K38/1709 ,  A61K47/14 ,  A61K47/20 ,  A61K47/34

摘要： The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days.

摘要翻译： 本发明提供了用于将活性剂特别是治疗性蛋白质递送至眼睛的可注射药物缓释制剂。 制剂是包含低溶解度液体赋形剂和相对少量（小于约10％）生物相容性，可生物降解的聚合物如PLA或PLGA聚合物的生物相容性，可生物降解的持续释放制剂。 单位剂量为5μL至100μL的制剂可使药剂持续释放至少14天。

公开(公告)号：US20210379291A1

公开(公告)日：2021-12-09

申请号：US17408908

申请日：2021-08-23

申请人： ICON BIOSCIENCE, INC.

发明人： Cathy Ann GERLETT

IPC分类号： A61M5/315 ,  A61M5/28

摘要： A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

公开(公告)号：US11097061B2

公开(公告)日：2021-08-24

申请号：US16269910

申请日：2019-02-07

申请人： ICON BIOSCIENCE, INC.

发明人： Cathy Ann Gerlett

IPC分类号： A61M5/315 ,  A61M5/28

摘要： A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

公开(公告)号：US09636347B2

公开(公告)日：2017-05-02

申请号：US15018461

申请日：2016-02-08

申请人： Icon Bioscience, Inc.

发明人： Vernon G. Wong ,  Mae W. Hu ,  Glenn T. Huang

IPC分类号： A61K31/216 ,  A61K31/5575 ,  A61K9/00 ,  A61K47/14

CPC分类号： A61K31/5575 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/14

摘要： The present embodiments provide for methods of treating elevated intraocular pressure or glaucoma using a sustained release medicament consisting of prostaglandin in benzyl benzoate that is injected intraocularly no more frequently than once every two months.