利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.029 秒)

    IMPLANTS AND METHODS FOR TREATING INFLAMMATION-MEDIATED CONDITIONS OF THE EYE
    7.
    发明申请
    IMPLANTS AND METHODS FOR TREATING INFLAMMATION-MEDIATED CONDITIONS OF THE EYE 有权
    用于治疗眼睛炎症介导的病症的植入物和方法

    公开(公告)号：US20100099655A1

    公开(公告)日：2010-04-22

    申请号：US12646522

    申请日：2009-12-23

    申请人： Vernon G. Wong ,  Mae W.L. Hu

    发明人： Vernon G. Wong ,  Mae W.L. Hu

    IPC分类号： A61K31/573 ,  A61P27/02

    CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0051 ,  A61K31/56 ,  A61K31/57 ,  A61K47/34

    摘要： Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 μg/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 μg/ml dexamethasone for at least about three weeks.

    摘要翻译： 描述了用于治疗炎症介导的眼睛状况的方法，其包括：将包含甾体抗炎剂和生物可腐蚀性聚合物的生物可蚀损植入物植入人的眼睛的玻璃体中，其中所述植入物将所述药剂递送至玻璃体 在约48小时内足以达到相当于至少约0.05μg/ ml地塞米松的浓度的量并保持至少约0.03μg/ ml地塞米松的浓度至少约三周。

    Biocompatible ocular implants
    8.
    发明授权
    Biocompatible ocular implants 失效
    生物相容性眼部植入物

    公开(公告)号：US5824072A

    公开(公告)日：1998-10-20

    申请号：US698238

    申请日：1996-08-14

    申请人： Vernon G. Wong

    发明人： Vernon G. Wong

    IPC分类号： A61F2/14 ,  A61F9/00 ,  A61K9/00

    CPC分类号： A61F9/0017 ,  A61K9/0051

    摘要： Implants comprising active agents are employed for introduction into a suprachoroidal space or an avascular region of an eye for therapeutic purposes. The administration of drugs is controlled and maintained for long periods of time, while ensuring the substantial absence of significant levels outside the site of administration.

    摘要翻译： 为了治疗目的，包含活性剂的植入物被用于引入到脉管外空间或眼睛的无血管区域中。 药物的管理长期控制和维持，同时确保在管理现场之外实质上没有显着的水平。

    Method of treatment of macular degeneration
    9.
    发明授权
    Method of treatment of macular degeneration 失效
    治疗黄斑变性的方法

    公开(公告)号：US5632984A

    公开(公告)日：1997-05-27

    申请号：US314534

    申请日：1994-09-28

    申请人： Vernon G. Wong ,  King Y. Lee ,  Jerry B. Gin

    发明人： Vernon G. Wong ,  King Y. Lee ,  Jerry B. Gin

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K38/21

    CPC分类号： A61K38/212 ,  A61K9/0048 ,  A61K9/1647

    摘要： Intraocular administration of drugs such as .alpha.-2a interferon is employed in the treatment of age-related macular degeneration. Intraocular administration obviates the side effects associated with systemic administration, concentrates the drug at the site of the disease, and, where microcapsules are employed, provides continuous, long-lasting treatment.

    摘要翻译： 药物如α-2a干扰素的眼内给药用于治疗年龄相关性黄斑变性。 眼内给药消除与全身给药相关的副作用，将药物浓集在疾病部位，并且在使用微胶囊的地方提供连续的持久治疗。

    Tonometer having acoustic coupling detection
    10.
    发明授权
    Tonometer having acoustic coupling detection 失效
    眼压计具有声耦合检测

    公开(公告)号：US4886066A

    公开(公告)日：1989-12-12

    申请号：US244144

    申请日：1988-09-13

    申请人： Thomas J. Ingalz ,  Jerry B. Gin ,  Vernon G. Wong

    发明人： Thomas J. Ingalz ,  Jerry B. Gin ,  Vernon G. Wong

    IPC分类号： A61B3/16

    CPC分类号： A61B3/16

    摘要： A tonometer for measuring the intraocular pressure of an eye featuring an acoustic signaling system for determining the beginning of a pressure measurement. The acoustic system includes a consumable cap having a pair of annular raised surface portions spaced by a recessed area. The raised surface portions provide an eye-engaging surface at the face of the tonometer. A pressure transmitting plunger concentrically suspended between the raised surface portions by a plurality of spider arms combines with the eye-engaging surface to provide a contour which complements a shape of an eye. The recessed area is open along the eye-engaging surface, yet defines a generally enclosed volume when full tonometer-to-eye contact is made. Spaced apart inlet and outlet apertures within the recessed area permit channeling of an acoustic signal to and from the recessed area. Prior to proper coupling of the tonometer to an eye, a substantial amount of the energy of the acoustic signal is lost to free air. However, upon achieving full tonometer-to-eye contact the energy is captured within the recessed ara and channeled to an acoustic receiver when the plunger contacts the eye, constricting the inlet-to-outlet acoustic wave path. Characteristic change of the received signal is marked by a hold signal triggered to initiate an intraocular pressure measurement. Proper coupling may be detected by either monitoring the phase or the change in amplitude at the acoustic wave receiver. Intraocular pressure is measured by means of the plunger which is operatively coupled to a force transducer.

    摘要翻译： 一种用于测量眼睛眼压的眼压计，其特征在于用于确定压力测量开始的声信号系统。 声学系统包括具有由凹陷区域隔开的一对环形凸起表面部分的消耗品盖。 凸起表面部分在眼压计的表面处提供眼睛接合表面。 通过多个蜘蛛臂同心地悬挂在凸起表面部分之间的压力传递柱塞与眼睛接合表面结合以提供补充眼睛形状的轮廓。 凹陷区域沿着眼睛接合表面是开放的，但是当进行全眼压眼睛接触时限定了大致封闭的体积。 凹陷区域内的间隔开的入口和出口孔允许将声学信号传导到凹陷区域和从该凹陷区域传播。 在将眼压计正确连接到眼睛之前，声信号的大量能量会损失到空气中。 然而，当实现全压力眼对接接触时，能量被捕获在凹陷区域内，并且当柱塞接触眼睛并且限制入口到出口声波路径时被引导到声学接收器。 接收到的信号的特征改变由触发的保持信号标记以启动眼内压测量。 可以通过监测声波接收器的相位或振幅的变化来检测适当的耦合。 通过可操作地耦合到力传感器的柱塞来测量眼内压。