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    Methods of treating certain depressive disorders and delirium tremens
    6.
    发明授权
    Methods of treating certain depressive disorders and delirium tremens 有权

    公开(公告)号：US10391105B2

    公开(公告)日：2019-08-27

    申请号：US15700314

    申请日：2017-09-11

    申请人： Marinus Pharmaceuticals Inc.

    发明人： Christopher Cashman ,  Jaakko Lappalainen ,  David A Czekai

    IPC分类号： A61K31/56 ,  A61K31/573 ,  C07J7/00 ,  A61K31/721 ,  A61K31/718

    摘要： The disclosure provides a method of treating a patient having postpartum depression, premenstrual dysphoric disorder, menopausal depression, or delirium tremens comprising administering an effective amount of an injectable neurosteroid formulation to the patient. In certain embodiments the injectable neurosteroid formulation is an injectable ganaxolone formulation. Two types of injectable neurosteroid formulations may be used in the disclosed methods. The first such formulation is an injectable formulation containing ganaxolone and sulfobutyl ether β-cyclodextrin in a 1:1 inclusion complex. The second such formulation is an injectable neurossteroid formulation comprising a neurosteroid, preferably ganaxolone, but which may be a neurosteroid selected from allopregnanolone, ganaxolone, alphaxalone, alphadolone, hydroxydione, minaxolone, pregnanolone, tetrahydrocorticosterone, and combinations of the foregoing; a surface stabilizer selected from hydroxyl ethyl starch, dextran, and povidone; and a surfactant.

    PSEUDOBASE BENZO[C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY
    9.
    发明申请
    PSEUDOBASE BENZO[C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY 有权
    PSEUDOBASE BENZO [C]具有改善效率，稳定性和安全性的苯并噻唑

    公开(公告)号：US20080076781A1

    公开(公告)日：2008-03-27

    申请号：US11831498

    申请日：2007-07-31

    申请人： Kenneth Shaw ,  Mingbao Zhang

    发明人： Kenneth Shaw ,  Mingbao Zhang

    IPC分类号： A61K31/44 ,  A61K31/4965 ,  A61P43/00 ,  C07D221/18 ,  C07D241/00 ,  C07D487/22

    CPC分类号： C07D491/04

    摘要： Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.

    摘要翻译： 本文提供了假碱性苯并[c]菲啶及其式I的药学上可接受的盐。 变量R 1，R 1，R 2，R 3和R 4在本文中定义。 本文提供的某些假碱性苯并[c]菲啶用作前药，将母体苯并[c]菲啶生物碱靶向体内的亲水或疏水区域。 本文提供了包含假碱性苯并[c]菲啶和载体，赋形剂或稀释剂的药物组合物。 还提供了治疗或预防微生物，真菌和/或病毒感染的方法以及治疗对蛋白激酶C调节，拓扑异构酶I和/或拓扑异构酶II调节的疾病和病症的方法。