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公开(公告)号：US10179935B2
公开(公告)日：2019-01-15
申请号：US10565068
申请日：2004-07-16
IPC分类号： C12Q1/6886 , G01N33/574 , C12Q1/6837
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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2.发明申请公开(公告)号：US20180298452A1
公开(公告)日：2018-10-18
申请号：US15988491
申请日：2018-05-24
申请人： Pacific Edge Limited
IPC分类号： C12Q1/6886 , G06F19/20 , G01N33/566 , G01N33/574
摘要： Embodiments of this invention include methods for detection of markers of bladder cancer and inflammatory conditions of the bladder. Particularly, methods include detection of expression of certain genetic markers for bladder cancer and markers for detection of inflammatory conditions of the bladder. These methods provide improved detection of the markers, and provide better detection of bladder cancer and inflammatory conditions of the bladder.
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公开(公告)号：US09809860B2
公开(公告)日：2017-11-07
申请号：US14920552
申请日：2015-10-22
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/574 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： This invention relates to test kits and methods for their use in determining the expression levels of genetic markers. Additionally, this invention relates to kits and uses thereof for the determination of ratios of genetic markers. Ratios of genetic markers can be used to assist in analysis of bladder cancer from samples of urine.
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公开(公告)号：US20170292956A1
公开(公告)日：2017-10-12
申请号：US15096943
申请日：2016-04-12
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： G01N33/574 , G06F19/20 , C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N2333/47 , G01N2333/4725 , G06F19/20
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.
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公开(公告)号：US20170107583A1
公开(公告)日：2017-04-20
申请号：US15391293
申请日：2016-12-27
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
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公开(公告)号：US20170088900A1
公开(公告)日：2017-03-30
申请号：US15233604
申请日：2016-08-10
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57419 , G01N33/57446 , G01N2800/60
摘要： This invention relates to test kits, methods and compositions for evaluating expression of genetic markers useful in determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to PCT test kits and their use to determine expressing of genetic markers based on cell proliferation signatures.
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公开(公告)号：US08822149B2
公开(公告)日：2014-09-02
申请号：US12592385
申请日：2009-11-23
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是对于黑素瘤。 具体而言，本发明涉及遗传和蛋白质标记物用于基于标记物和标记物的标记来预测癌症进展风险（例如黑素瘤）的用途。 在各个方面，本发明提供了基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以帮助癌症的预后和治疗。
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公开(公告)号：US11180815B2
公开(公告)日：2021-11-23
申请号：US16552737
申请日：2019-08-27
申请人： Pacific Edge Limited
发明人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
IPC分类号： C12Q1/6886 , G16B20/00 , G01N33/574 , G16B20/20 , G16B25/10 , G16B25/00
摘要： This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.
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公开(公告)号：US10422005B2
公开(公告)日：2019-09-24
申请号：US12214782
申请日：2008-06-20
申请人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
发明人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886 , G01N33/574 , G16B20/00 , G16B25/00
摘要： This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.
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公开(公告)号：US10266902B2
公开(公告)日：2019-04-23
申请号：US15391293
申请日：2016-12-27
IPC分类号： C12Q1/68 , G06F19/00 , C12Q1/6886 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
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