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公开(公告)号：US11180815B2
公开(公告)日：2021-11-23
申请号：US16552737
申请日：2019-08-27
申请人： Pacific Edge Limited
发明人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
IPC分类号： C12Q1/6886 , G16B20/00 , G01N33/574 , G16B20/20 , G16B25/10 , G16B25/00
摘要： This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.
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2.发明申请公开(公告)号：US20180094323A1
公开(公告)日：2018-04-05
申请号：US15798922
申请日：2017-10-31
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/574
摘要： This invention relates to methods for detecting the presence of genetic markers for transitional cell carcinoma of the bladder. Specifically, this invention relates to detection of expression of overexpressed and underexpressed genetic markers and calculation of ratios of expression of these markers. In additional aspects, the invention relates to polymerase chain reaction (PCR) based kits for carrying out these methods.
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3.发明申请公开(公告)号：US20170275697A1
公开(公告)日：2017-09-28
申请号：US15159359
申请日：2016-05-19
申请人： Pacific Edge Limited
发明人： David Darling , James Miller Suttie , Mark Dalphin , Laimonis Kavalieris , Paul O'Sullivan , Satish Kumar
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/50 , G01N33/57407 , G01N33/57484 , G01N2800/60
摘要： New methods for identifying patents with hematuria who are at low risk of having urothelial cancer (UC) include combining selected phenotypic variables with levels of genotypic expression into a new metric, the “G+P INDEX.” The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. For groups 1 and 2, further clinical and laboratory work up is indicated, and patients in group 3 are monitored periodically to determine the need for further clinical workup. Using the G+P INDEX can save substantial time, effort, and funds by avoiding unnecessary medical diagnostic procedures for patients at Low Risk of UC.
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公开(公告)号：US10689711B2
公开(公告)日：2020-06-23
申请号：US15798922
申请日：2017-10-31
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/6886 , G01N33/574 , G16H50/20
摘要： This invention relates to methods for detecting the presence of genetic markers for transitional cell carcinoma of the bladder. Specifically, this invention relates to detection of expression of overexpressed and underexpressed genetic markers and calculation of ratios of expression of these markers. In additional aspects, the invention relates to polymerase chain reaction (PCR) based kits for carrying out these methods.
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公开(公告)号：US10689707B2
公开(公告)日：2020-06-23
申请号：US15252869
申请日：2016-08-31
申请人： Pacific Edge Limited
IPC分类号： C12Q1/6886 , G01N33/574 , C12Q1/6837
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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6.发明申请公开(公告)号：US20200115757A9
公开(公告)日：2020-04-16
申请号：US15798922
申请日：2017-10-31
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/574
摘要： This invention relates to methods for detecting the presence of genetic markers for transitional cell carcinoma of the bladder. Specifically, this invention relates to detection of expression of overexpressed and underexpressed genetic markers and calculation of ratios of expression of these markers. In additional aspects, the invention relates to polymerase chain reaction (PCR) based kits for carrying out these methods.
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公开(公告)号：US10024859B2
公开(公告)日：2018-07-17
申请号：US15096943
申请日：2016-04-12
申请人： Pacific Edge Limited
发明人： Parry John Guilford
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/6886 , G06F19/20
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.
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公开(公告)号：US09534258B2
公开(公告)日：2017-01-03
申请号：US14472755
申请日：2014-08-29
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是对于黑素瘤。 具体而言，本发明涉及遗传和蛋白质标记物用于基于标记物和标记物的标记来预测癌症进展风险（例如黑素瘤）的用途。 在各个方面，本发明提供了基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以帮助癌症的预后和治疗。
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公开(公告)号：US20160102368A1
公开(公告)日：2016-04-14
申请号：US14920552
申请日：2015-10-22
申请人： Pacific Edge Limited
发明人： Parry John Guilford
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： This invention relates to test kits and methods for their use in determining the expression levels of genetic markers. Additionally, this invention relates to kits and uses thereof for the determination of ratios of genetic markers. Ratios of genetic markers can be used to assist in analysis of bladder cancer from samples of urine.
摘要翻译： 本发明涉及测定试剂盒及其用于确定遗传标记物表达水平的方法。 此外，本发明涉及用于确定遗传标记的比例的试剂盒及其用途。 遗传标记的比例可用于协助尿液样本分析膀胱癌。
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公开(公告)号：US20150031578A1
公开(公告)日：2015-01-29
申请号：US14472755
申请日：2014-08-29
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是对于黑素瘤。 具体而言，本发明涉及遗传和蛋白质标记物用于基于标记物和标记物的标记来预测癌症进展风险（例如黑素瘤）的用途。 在各个方面，本发明提供了基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以帮助癌症的预后和治疗。
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