公开(公告)号：US20240122697A1

公开(公告)日：2024-04-18

申请号：US18392866

申请日：2023-12-21

申请人： PRECISE BIO 3D LTD

发明人： Ariel EISENBACH ,  Amos EITAN ,  Michal MARCUS ,  Maayan MALKI ,  Lior ROSENBERG BELMAKER ,  Shai GARTY ,  Rajesh KUMAR ,  Lior SHAV ,  Aryeh BATT

IPC分类号： A61F2/14 ,  A61L27/24 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  B33Y80/00

CPC分类号： A61F2/1451 ,  A61L27/24 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/52 ,  B33Y80/00 ,  A61F2240/001

摘要： The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

公开(公告)号：US20230310709A1

公开(公告)日：2023-10-05

申请号：US18129875

申请日：2023-04-02

申请人： Precise-Bio 3D LTD.

发明人： Amos EITAN ,  Aryeh Batt ,  Ariel Eisenbach ,  Dorin Sade Yazdi ,  Michal Marcus ,  Lior Rosenberg Belmaker ,  Maayan Malki ,  Gal Shenbach-Koltin

IPC分类号： A61L27/36 ,  A61L27/24 ,  A61L27/38 ,  B41J3/407

CPC分类号： A61L27/3666 ,  A61L27/3604 ,  A61L27/24 ,  A61L27/3834 ,  A61L27/3869 ,  A61L27/3687 ,  B41J3/407 ,  A61L2430/16

摘要： A method of manufacturing a retinal graft. The method includes: (a) preparing a scaffold material solution; (b) air-drying the scaffold material solution, to form a thin scaffold layer; (c) crosslinking the thin scaffold layer; (d) rehydrating the scaffold layer; and (e) applying retinal pigment epithelium cells onto the scaffold layer.

公开(公告)号：US10940687B2

公开(公告)日：2021-03-09

申请号：US16605319

申请日：2018-04-16

申请人： Precise Bio Inc ,  Precise Bio 3D LTD

发明人： Aryeh Batt ,  Amos Eitan ,  Ariel Eisenbach

IPC分类号： B41J2/14 ,  B41M5/40 ,  B41J2/045 ,  B41M5/42

摘要： Methods and systems for Laser-Induced Forward Transfer are disclosed in which a microfluidic chip is used as the printing head. The head comprises a transparent upper region, a middle region comprising an intermediate layer channel and an ink channel in fluid connection with said intermediate layer channel, and a lower layer with an orifice in fluid contact with the ink channel. When material in the intermediate layer channel is irradiated by an energy source (typically a pulsed laser) at a spot opposite the orifice, the material is partially evaporated, creating a vapor bubble that creates a transient pressure increase when it collapses, thereby forcing ink out of the orifice and onto a receiving substrate.

公开(公告)号：US20230172704A1

公开(公告)日：2023-06-08

申请号：US18088673

申请日：2022-12-26

申请人： PRECISE BIO 3D LTD

发明人： Ariel EISENBACH ,  Amos EITAN ,  Michal MARCUS ,  Lior ROSENBERG BELMAKER ,  Shai GARTY ,  Rajesh KUMAR ,  Lior SHAV ,  Aryeh BATT

IPC分类号： A61F2/14 ,  B33Y80/00 ,  A61L27/24 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52

CPC分类号： A61F2/1451 ,  B33Y80/00 ,  A61L27/24 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/52 ,  A61F2240/001

摘要： The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

公开(公告)号：US20230000617A1

公开(公告)日：2023-01-05

申请号：US17766670

申请日：2020-10-06

申请人： PRECISE BIO 3D LTD

发明人： Ariel EISENBACH ,  Amos EITAN ,  Michal MARCUS ,  Lior ROSENBERG BELMAKER ,  Shai GARTY ,  Rajesh KUMAR ,  Lior SHAV ,  Aryeh BATT

IPC分类号： A61F2/14 ,  A61L27/38 ,  A61L27/34 ,  A61L27/24 ,  A61L27/52 ,  B33Y80/00

摘要： The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

公开(公告)号：US20240359498A1

公开(公告)日：2024-10-31

申请号：US18764235

申请日：2024-07-04

申请人： PRECISE BIO 3D LTD

发明人： Aryeh BATT ,  Amos EITAN ,  Ariel EISENBACH ,  Yishay HAYARDENI ,  Lior YEDIDYA

IPC分类号： B41M5/40 ,  A61M37/00 ,  B41J2/14 ,  B41J2/475 ,  B41J3/44 ,  B41M5/00 ,  B41M5/42 ,  C23C14/04 ,  C23C14/28

CPC分类号： B41M5/40 ,  A61M37/0015 ,  B41J2/475 ,  B41J3/445 ,  B41M5/0011 ,  B41M5/42 ,  C23C14/048 ,  C23C14/28 ,  A61M2037/003 ,  B41J2002/14322 ,  B41M2205/08

摘要： A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.

公开(公告)号：US20240207042A1

公开(公告)日：2024-06-27

申请号：US18682924

申请日：2022-08-07

申请人： PRECISE BIO 3D LTD

发明人： Yossi BOUKOBZA ,  Amos EITAN ,  Ariel EISENBACH ,  Eliahu ELIACHAR ,  Michal MARCUS ,  Gilad RABINA ,  Lior ROSENBERG BELMAKER ,  Amit SEGAL ,  Dorin SADE YAZDI

IPC分类号： A61F2/14 ,  A61F9/00 ,  A61L27/36

CPC分类号： A61F2/148 ,  A61F2/142 ,  A61F9/0017 ,  A61L27/3604 ,  A61L27/3675 ,  A61L2430/16

摘要： The present invention provides an insertion tool for inserting an implant, said implant having an implant lower side and an implant upper side, said implant upper side comprising cells, said insertion tool comprising: an implant carrier configured to hold said implant; and a body having at least two configurations, a first body configuration with said implant carrier at least partially contained within said body and said implant held by said implant carrier and a second body configuration with said implant carrier outside said body; said implant carrier is configured to maintain a position of the implant and a shape of the implant and functionality of said cells during such time as the implant carrier is contained by said body, and during an implantation procedure.