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37 条记录 (耗时 0.017 秒)

    NOVEL ALLERGEN
    1.
    发明申请
    NOVEL ALLERGEN 审中-公开

    公开(公告)号：US20170219602A1

    公开(公告)日：2017-08-03

    申请号：US15327253

    申请日：2015-07-20

    申请人： PHADIA AB

    发明人： Lars MATTSSON ,  Ulrica OLSSON ,  Thomas LUNDGREN ,  Jonas LIDHOLM ,  Håkan LARSSON

    IPC分类号： G01N33/68 ,  C07K14/47

    摘要： The invention relates to a novel horse allergen consisting of a heterodimeric protein having a first peptide chain and a second peptide chain together having an overall sequence identity of at least 70% with the combined sequences of SEQ ID NO:3 and SEQ ID NO: 4, as well as a single chain protein having an overall sequence identity of at least 70%, such as 75%, 80%, 85%, 90%, 95%, or 98%, with the combined amino acid sequences according to SEQ ID NO: 3 and SEQ ID NO: 4. The invention further relates to the use of the protein in methods of diagnosis and therapy of Type I allergy, and kits and compositions for use in such methods.

    Recombinant polypeptides having Ph1 p I epitope antigenicity and methods of diagnosing allergy in vitro
    2.
    发明授权
    Recombinant polypeptides having Ph1 p I epitope antigenicity and methods of diagnosing allergy in vitro 有权
    具有Ph1 p I表位抗原性的重组多肽和在体外诊断变态反应的方法

    公开(公告)号：US07148019B2

    公开(公告)日：2006-12-12

    申请号：US10161660

    申请日：2002-06-05

    申请人： Tanja Ball ,  Susanne Vrtala ,  Wolfgang Sperr ,  Peter Valent ,  Markus Susani ,  Dietrich Kraft ,  Rudolf Valenta ,  Sylvia Laffer

    发明人： Tanja Ball ,  Susanne Vrtala ,  Wolfgang Sperr ,  Peter Valent ,  Markus Susani ,  Dietrich Kraft ,  Rudolf Valenta ,  Sylvia Laffer

    IPC分类号： G01N33/53 ,  G01N7/00 ,  G01N14/00 ,  C12N15/62

    CPC分类号： C07K14/415 ,  A61K38/00 ,  C07K2319/00

    摘要： A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 45, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114), with the amino acid sequences defined in SEQ ID NOS: 5, 7, 9 and 12–28, and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high, stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114). Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.

    摘要翻译： 一种重组DNA分子，其包含核苷酸序列（I），其编码显示一种，两种或更多种Phl p I表位克隆（28,34,41,42,43,45,50,52,64）的抗原性的多肽 ，80,85,86,95,97,98,103,108,109,113,114），其氨基酸序列在SEQ ID NO：5,7,9和12-28中定义，优选衍生自 草或单子叶植物，或在高度严格的条件下与这种核苷酸序列（I）杂交的核苷酸序列（II）。 显示一种，两种或更多种Phl p I表位克隆（28,34,41,42,43,50,52,64,80,85,86,85,97,98,103,108， 109，113，114）。 含有载体转化的重组分子和宿主细胞的重组表达载体。 基于在免疫测定中利用多肽进行体液抗体和细胞反应的诊断方法。

    Recombinantly produced allergens
    3.
    发明授权
    Recombinantly produced allergens 有权

    公开(公告)号：US09757447B2

    公开(公告)日：2017-09-12

    申请号：US14984482

    申请日：2015-12-30

    申请人： PHADIA AB

    发明人： Lars Mattsson ,  Jonas Lidholm ,  Thomas Lundgren

    IPC分类号： A61K39/35 ,  A61K39/00 ,  C07K14/47 ,  G01N33/68

    CPC分类号： A61K39/35 ,  A61K39/001 ,  C07K14/47 ,  G01N33/6854 ,  G01N2800/24

    摘要： Methods for producing an allergen composition, methods for in vitro diagnosis of type I allergy, and diagnostic kits for performing diagnosis employ Bos d 23k allergen of SEQ ID NO: 4, or the mature protein thereof, or a variant or fragment of the Bos d 23k allergen or the mature protein sharing epitopes for antibodies with the Bos d 23k allergen or the mature protein. Methods for treatment of a Type I allergy to a mammal and pharmaceutical compositions employ a Bos d 23k allergen of SEQ ID NO: 4, or the mature protein thereof, or a variant or fragment of the Bos d 23k allergen or the mature protein sharing epitopes for antibodies with the Bos d 23k allergen or the mature protein, wherein the Bos d 23k allergen, the mature protein, the variant or the fragment is modified to abrogate or attenuate its IgE binding response.

    Calibration Reagent and Method
    5.
    发明申请
    Calibration Reagent and Method 审中-公开
    校准试剂和方法

    公开(公告)号：US20140228244A1

    公开(公告)日：2014-08-14

    申请号：US14344894

    申请日：2012-09-14

    申请人： Göran Elfverson ,  Per Matsson ,  Mats Nystrand

    发明人： Göran Elfverson ,  Per Matsson ,  Mats Nystrand

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5302 ,  C07K16/00 ,  G01N33/6854 ,  G01N33/96

    摘要： The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilised, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilised on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent.

    摘要翻译： 本发明涉及一种用于校准多重测定的方法，包括：向固定有多个捕获剂的固相添加校准试剂，加入具有结合校准试剂的能力的检测分子，检测结合 检测分子，从而产生校准曲线，其中校准试剂包含至少两种不同的结合分子，其中每个结合分子具有特异性结合固定在固相上的捕获剂和与检测分子结合的能力的能力。 还提供了包含这种校准试剂的多重测定系统。

    Analytical method and kit thereof
    6.
    发明授权
    Analytical method and kit thereof 有权
    分析方法及试剂盒

    公开(公告)号：US07833983B2

    公开(公告)日：2010-11-16

    申请号：US10551636

    申请日：2004-04-02

    申请人： Michael Mahler

    发明人： Michael Mahler

    IPC分类号： A61K38/10 ,  G01N33/53

    CPC分类号： C07K14/525 ,  C07K14/4713 ,  G01N33/564 ,  G01N2800/104

    摘要： The present invention relates to a peptide comprising a symmetrical dimethylated arginine, and constitute an immunologic determinant of antibodies present in sera from patients with systemic lupus erythematosus (SLE), and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptide for diagnosis of SLE and the differentiation between SLE and MCTD.

    摘要翻译： 本发明涉及包含对称的二甲基化精氨酸的肽，并构成存在于患有系统性红斑狼疮（SLE）患者的血清中的抗体的免疫决定簇，其中甲基化是与所述抗体反应的先决条件。 本发明还涉及所述肽用于SLE诊断和SLE与MCTD之间区分的用途。

    METHOD FOR THE HARMONIZATION OF ASSAY RESULTS
    9.
    发明申请
    METHOD FOR THE HARMONIZATION OF ASSAY RESULTS 有权

    公开(公告)号：US20210057054A1

    公开(公告)日：2021-02-25

    申请号：US15733402

    申请日：2019-01-22

    申请人： Phadia AB

    发明人： Per MATSSON ,  Karl ANDERSSON ,  Joseph BERNARDO

    IPC分类号： G16H10/40 ,  G01N33/574 ,  G16H50/70

    摘要： Methods for harmonization of test results from a biological sample in a multiplexed biochemical assay, wherein presence and/or concentration of multiple biomarkers are determined at the same time in the same sample, making test results obtained in different laboratories comparable comprise: quantifying a presence or concentration of at least two different biomarkers in a biological sample and in a harmonization standard sample, independently in each sample, by means of a defined multiplexed biochemical assay implemented in a defined type of analytical instrument; receiving the test results from the samples into a computer-based decision engine for harmonization of test results from biological samples; and transforming the test results received from the biological sample, which includes transforming the test results from the harmonization standard sample into generalized units and adjusting the test results of the biological sample into the generalized units, GE.

    Calibration reagent and method
    10.
    发明授权
    Calibration reagent and method 有权

    公开(公告)号：US10379110B2

    公开(公告)日：2019-08-13

    申请号：US14344894

    申请日：2012-09-14

    申请人： Göran Elfverson ,  Per Matsson ,  Mats Nystrand

    发明人： Göran Elfverson ,  Per Matsson ,  Mats Nystrand

    IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/96 ,  C07K16/00

    摘要： The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilized, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilized on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent.