公开(公告)号：US11518801B1

公开(公告)日：2022-12-06

申请号：US16228293

申请日：2018-12-20

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61P3/10 ,  A61K39/00 ,  A61K39/395 ,  C07K16/18 ,  A61K9/00

摘要： A method of treating or preventing the onset of diabetes or diabetic complications comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating or preventing the onset of diabetes or diabetic complications comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of diabetes or diabetic complications comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

公开(公告)号：US10995151B1

公开(公告)日：2021-05-04

申请号：US15863784

申请日：2018-01-05

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/44 ,  A61K47/64

摘要： A method of treating disease-related cachexia comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating disease-related cachexia comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of disease-related cachexia comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

公开(公告)号：US10960234B2

公开(公告)日：2021-03-30

申请号：US14920737

申请日：2015-10-22

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61B8/00 ,  A61N7/00 ,  C12N13/00 ,  C12N5/00 ,  A61B17/32

摘要： A method of treating a condition associate with accumulation of an agent in cells in a patient includes exposing the cells to ultrasound, to selectively kill or induce apoptosis in the cells. The cells include the accumulated agent.

公开(公告)号：US10925937B1

公开(公告)日：2021-02-23

申请号：US15863741

申请日：2018-01-05

申请人： Siwa Corporation

发明人： Lewis S. Gruber ,  Misty S. Gruber

IPC分类号： A61K47/64 ,  A61K39/00

摘要： Various juvenile disorders associated with inflammation may be treated or prevented by immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell. Immunizing a subject includes administering a vaccine that comprises an AGE antigen. Vaccines against AGE-modified proteins or peptides contain an AGE antigen, an adjuvant, optional preservatives and optional excipients.

公开(公告)号：US20240000930A1

公开(公告)日：2024-01-04

申请号：US18265205

申请日：2021-12-09

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61P13/12

CPC分类号： A61K39/3955 ,  A61K39/0005 ,  A61P13/12

摘要： A method of treating or preventing the onset of kidney disease comprises administering to a subject a composition comprising an anti-AGE antibody. The anti-AGE antibody binds an AGE antigen comprising at least one protein or peptide that exhibits AGE modifications selected from the group consisting of FFI, pyrraline, AFGP, ALI, carboxymethyllysine, carboxyethyllysine and pentosidine. A method of treating or preventing the onset of kidney disease comprises administering to a subject a vaccine comprising an AGE antigen.

公开(公告)号：US11213585B2

公开(公告)日：2022-01-04

申请号：US16311149

申请日：2016-06-23

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61K39/39 ,  A61K39/00 ,  C07K16/44 ,  A61K39/395 ,  A61P35/04

摘要： Various diseases and disorders associated with cellular senescence may be treated by immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell Immunizing a subject includes administering a vaccine that comprises an AGE antigen. Vaccines against AGE-modified proteins or peptides contain an AGE antigen, an adjuvant, optional preservatives and optional excipients.

公开(公告)号：US20210253737A1

公开(公告)日：2021-08-19

申请号：US17209554

申请日：2021-03-23

申请人： SIWA Corporation

发明人： Lewis S. Gruber

IPC分类号： C07K16/44 ,  A61K39/395 ,  A61K39/00 ,  A61K47/64

摘要： A method of treating disease-related cachexia comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating disease-related cachexia comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of disease-related cachexia comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

公开(公告)号：US10961321B1

公开(公告)日：2021-03-30

申请号：US15863828

申请日：2018-01-05

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61P19/02 ,  A61K39/00 ,  A61K39/395 ,  C07K16/44 ,  A61K47/64

摘要： A method of treating pain associated with inflammation comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating pain associated with inflammation comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of pain associated with inflammation comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

公开(公告)号：US10584180B2

公开(公告)日：2020-03-10

申请号：US15511731

申请日：2015-09-15

申请人： Siwa Corporation

发明人： Lewis S. Gruber

IPC分类号： A61K39/00 ,  C07K16/44 ,  C07K16/24

摘要： A composition for treating inflammation or auto-immune disorders comprises (i) an antibody that binds to an AGE-modified protein on a cell, and (ii) an anti-inflammation antibody. Furthermore, the antibody that binds to an AGE-modified protein on a cell is also effective to treat inflammation or auto-immune disorders alone.

公开(公告)号：US08721571B2

公开(公告)日：2014-05-13

申请号：US12951768

申请日：2010-11-22

申请人： Lewis Gruber

发明人： Lewis Gruber

IPC分类号： A61H1/00

CPC分类号： A61N7/00 ,  A61B8/00 ,  A61B17/320068 ,  C12N5/0093 ,  C12N13/00

摘要： A method of treating a condition associate with accumulation of an agent in cells in a patient includes exposing the cells to ultrasound, to selectively kill or induce apoptosis in the cells. The cells include the accumulated agent.

摘要翻译： 治疗与患者细胞中的药物累积相关联的病症的方法包括将细胞暴露于超声波，以选择性地杀死或诱导细胞凋亡。 细胞包括累积剂。