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公开(公告)号：US20230095339A1
公开(公告)日：2023-03-30
申请号：US17936648
申请日：2022-09-29
发明人： Jane Cleland-Huang , Ankit Agrawal
摘要： A method for sharing a point-of-interest across a plurality of video feeds from a plurality of optical imaging devices includes receiving an indication of the point-of-interest associated with a first video feed of the plurality of video feeds, the first video feed provided by a first optical imaging device of the plurality of optical imaging devices; determining a geo-location of an object associated with the point-of-interest; determining a position of a second optical imaging device relative to the determined geo-location of the point-of-interest; and overlaying the point-of-interest on a second video feed, the second video feed provided by the second optical imaging device.
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公开(公告)号：US11559514B2
公开(公告)日：2023-01-24
申请号：US16667227
申请日：2019-10-29
发明人： Gautam Dantas , Patrick Gonzales , Kevin Forsberg , Mitchell Pesesky , Mayland Chang , Shahriar Mobashery
IPC分类号： A61K31/424 , A61K31/431 , A61P31/04 , A61K31/407 , A61K45/06 , A61K31/546 , A61K31/43 , A61K31/496
摘要： The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.
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公开(公告)号：US11488660B2
公开(公告)日：2022-11-01
申请号：US17179478
申请日：2021-02-19
发明人： Gregory Snider , Rene Celis-Cordova , Alexei Orlov , Tian Lu , Jason M. Kulick
IPC分类号： H03K3/037 , G11C11/412
摘要： In a method computer storage element operation, first and second rising (or falling) clock edges are applied to first and second power inputs of the computer storage element having a transistor array between the first and second power inputs over time T1 whereupon a logic value applied to an input of the transistor array is stored therein. Thereafter, first and second falling (or rising) clock edges are applied to the first and second power inputs over time T2, whereupon part of an electrical charge or energy associated with the logic value stored in the transistor array is provided to circuitry that generates the first and/or second clock edge(s), wherein the value(s) of time T1 and/or time T2 is/are greater than a product of RC, where R is resistance associated with the computer storage element, and C is a load capacitance associated with the computer storage element.
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4.发明申请公开(公告)号：US20220325270A1
公开(公告)日：2022-10-13
申请号：US17639198
申请日：2020-10-02
IPC分类号： C12N15/10
摘要： Described herein is a bifurcated continuous field-flow fractionation (BCFFF) chip for high-yield and high-throughput nucleic acid extraction and purification. BCFFF uses a membrane ionic transistor to sustain low-ionic strength in a localized region at a junction, such that the resulting high field can selectively isolate high-charge density nucleic acids from the main flow channel and insert them into a standardized buffer in a side channel that bifurcates from the junction. The BCFFF platform can be used for isolation of both long dsDNAs and short miRNAs, without changing the device configuration or the operation protocol. BCFFF results in high-efficiency (>85%) concentration-independent DNA extraction and 40% net qRT-PCR miRNA yield from plasma, which is significantly higher than any other commercial liquid and solid extraction technologies.
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公开(公告)号：US20220253076A1
公开(公告)日：2022-08-11
申请号：US17571449
申请日：2022-01-07
摘要： A method for configuring a multiple autonomous drone mission includes displaying, a plurality of queries on a display of the computing device. The method further includes receiving, via a user interface, a plurality of inputs responsive to the plurality of queries. At least a first input of the plurality of inputs specifies a type of mission to be performed and at least a second input of the plurality of inputs specifies a geographical area in which a mission to be performed will be carried out. The method further includes automatically determining, based on the plurality of inputs, an initial location to move to for each of a plurality of drones available for implementing the mission. The method further includes automatically determining, based on the plurality of inputs, a series of tasks for each of the plurality of drones.
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公开(公告)号：US20220182092A1
公开(公告)日：2022-06-09
申请号：US17681323
申请日：2022-02-25
发明人： Ralf Bendlin , Jonathan David Chisum , Nicholas Joseph Estes , Bertrand Martyn Hochwald , Aditya Chopra
IPC分类号： H04B1/22 , H04L27/06 , H04B7/08 , H04B7/0413
摘要： Aspects of the subject disclosure may include, for example, receiving, by a first radio module at a first location, a wireless signal, to obtain a first received RF signal. The wireless signal includes information originating at a remote transmitter and conveyed via a wireless channel. An envelope of the first received RF signal is detected by the first radio module without requiring a local oscillator, to obtain a first baseband signal. The first baseband signal may be filtered and/or amplified, after which it is provided to a processor. The processor also obtains a second digital signal from a second radio module receiving the wireless signal at a second location and determines an estimate of the information originating at the remote transmitter according to the first and second signals. Other embodiments are disclosed.
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公开(公告)号：US20220125749A1
公开(公告)日：2022-04-28
申请号：US17568477
申请日：2022-01-04
IPC分类号： A61K31/167 , A61K47/40 , A61K47/10 , A61P25/02 , A61P25/04 , A61K47/60 , A61K45/06 , A61P25/00
摘要： The disclosure relates to use of a triple formulation comprising a histone deacytlase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.
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公开(公告)号：US20220011304A1
公开(公告)日：2022-01-13
申请号：US17297385
申请日：2018-12-20
发明人： Jiayun Hu , Paul W. Bohn , Marvin J. Miller , Manuka Ghosh
IPC分类号： G01N33/543 , C12N15/115 , G01N33/569 , G01N21/65
摘要： Described is a biosensor for detection of analytes and methods of using the same for detecting bacterial infection in a subject. The biosensor comprises an array of gold nanoparticles, biotinylated polyethylene glycol thiol, polyethylene glycol thiol, at least one neutravidin molecule, and at least one affinity reagent immobilized on a surface of the at least one neutravidin molecule. The affinity reagent may be an aptamer or a siderophore. The biosensors demonstrate extraordinary selectively and sensitivity for rapid detection of whole-cell bacteria.
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公开(公告)号：US11198911B2
公开(公告)日：2021-12-14
申请号：US16978903
申请日：2019-03-07
发明人： Steven Buechler
IPC分类号： C12Q1/6886 , G16H50/20 , G16H20/40 , G16H70/60 , G16H10/40 , G16B25/10 , G16B40/00 , G16B30/00
摘要： Products, systems, and methods for classifying human colorectal cancer into a consensus molecular subtype (CMS) and for assessing risk of recurrence based on CMS scores and based on risk scores derived from abbreviated gene expression profiles, for determining suitable treatment protocols for human colorectal cancer patients based on the determined CMS classification and based on the determined risk of recurrence, and for administering the suitable treatment protocols.
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10.发明授权公开(公告)号：US11155542B2
公开(公告)日：2021-10-26
申请号：US16335384
申请日：2017-09-21
申请人： Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie E.V. Hans-Knöll Institut (HKI) , Klinikum der Universität München , University of Notre Dame du Lac, Office of Technology Transfer
发明人： Florian Kloss , Sebastian Schieferdecker , Axel Brakhage , Julia Dreisbach , Marvin J. Miller , Ute Mollmann , Kamil Philip Wojtas
IPC分类号： C07D513/04 , A61P31/04 , A61P31/06 , C07D417/04
摘要： The present invention relates to the general field of treatment of infectious diseases of mammals (humans and animals) caused by bacteria, in particular to the treatment of diseases like tuberculosis (TB), Buruli ulcer and leprosy caused by mycobacteria. The invention aims at the generation of a new series of benzothiazinone compounds having the potential to overcome the above mentioned problems. In a preferred embodiment the invention is concerned with compounds of the general formula (I) wherein R1 represents NO2, R2 represents CF3, at least one of the substituents R3 and R4 is OH, SR14, NHR15, CN, N3, a saturated or unsaturated, optionally halogenated, linear or branched aliphatic radical having 1-4 carbon atoms, linear or branched C1-C4 alkoxy, C1-C4 acyl, and the other of R3 and R4 may in addition be hydrogen, R6 represents a 2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl or a 4-(cyclo-hexylmethyl)piperazin-1-yl group and R14 and R15 independently of each other are hydrogen or a C1-C4 alkyl group and/or a pharmaceutically acceptable salt thereof.
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