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公开(公告)号：US20240352907A1
公开(公告)日：2024-10-24
申请号：US18395513
申请日：2023-12-23
发明人： Mark Edward Noftz , Joseph Stephen Jewell , Andrew James Shuck , Jonathan Poggie , Andrew Nixon Bustard , Thomas James Juliano
IPC分类号： F02K7/10
CPC分类号： F02K7/10
摘要： Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.
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公开(公告)号：US12054466B2
公开(公告)日：2024-08-06
申请号：US17376522
申请日：2021-07-15
发明人： Mayland Chang , Shahriar Mobashery , Derong Ding
IPC分类号： C07D271/06 , A61K9/00 , A61K9/12 , A61K9/20 , A61K9/48 , A61L9/12 , A61P31/04 , C07D413/04 , C07D413/10 , C07D413/12
CPC分类号： C07D271/06 , A61K9/0014 , A61K9/0019 , A61K9/12 , A61K9/2027 , A61K9/2059 , A61K9/4866 , A61P31/04 , C07D413/04 , C07D413/10 , C07D413/12
摘要： Clostridium difficile infection (CDI) is a public health threat that results in 14,000 annual deaths in the United States. Challenges involve the production of CDI spores that can remain dormant for years and the production of toxins that damage the gut. Current therapies for CDI include vancomycin and metronidazole, but neither inhibits spore or toxin production. Thus, recurrence of infection occurs in 25% of patients and there are no antibiotics that are effective for multiple recurrences. We describe oxadiazoles with activity against C. difficile, including the highly virulent NAP1/027 strain with increased production of toxins A and B, as well as the additional binary toxin. Oxadiazole 2 is poorly absorbed, thus advantageously achieving high concentrations in the gut. The compound targets peptidoglycan synthesis and inhibits vegetative cells, spores, and toxin production.
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公开(公告)号：US12018092B2
公开(公告)日：2024-06-25
申请号：US17126466
申请日：2020-12-18
发明人： Zihni Basar Bilgicer , Peter Edward Deak , Tanyel Kiziltepe Bilgicer , Michael William Handlogten , Jonathan Darryl Ashley
IPC分类号： C07K16/46 , A61K9/127 , A61K38/05 , A61K38/07 , A61K47/02 , A61K47/10 , A61K47/54 , A61K47/62
CPC分类号： C07K16/46 , A61K9/127 , A61K38/05 , A61K38/07 , A61K47/02 , A61K47/10 , A61K47/54 , A61K47/62
摘要： The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment. These molecules contain four important components: (1) an IgE antigen binding site (ABS) ligand that can be a mimotope for the allergen protein, a small molecule, or a peptidomimetic, (2) an appropriate linker, which can be any flexible or rigid chemical linker, providing spacing between the ABS binder and the other moieties, (3) a nucleotide binding site (NBS) ligand, and (4) a reactive moiety to form a covalent link with an amino acid side chain of target IgE antibodies.
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公开(公告)号：US20240191279A1
公开(公告)日：2024-06-13
申请号：US18556228
申请日：2022-04-22
IPC分类号： C12Q1/6816
CPC分类号： C12Q1/6816 , C12Q2600/112 , C12Q2600/178
摘要： Described herein are methods and devices for rapid detection of miRNA and protein biomarkers for diagnosing myocardial infarction and reperfusion injury.
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5.发明授权公开(公告)号：US12004843B2
公开(公告)日：2024-06-11
申请号：US17045070
申请日：2019-04-05
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/0013 , A61B5/7228 , A61B5/742 , A61B2560/0214 , A61B2560/0223
摘要： A frequency domain diffuse optical spectroscopy (FD-DOS) device and calibration method. The FD-DOS device includes a radio frequency signal generator, a driver, a light source, a silicon photomultiplier, an analog to digital conversion circuit, and an electronic processing circuit. The light source is configured to generate modulated light at a plurality of different wavelengths and modulation frequencies. The silicon photomultiplier is configured to generate analog detection signals indicative of detected optical signals. The analog to digital conversion circuit is configured to generate digital sample values from the analog detection signals. The electronic processing circuit is configured to determine absorption values and scattering values based on the digital sample values. The electronic processing circuit is also configured to determine concentration values based on the absorption values and the scattering values. The electronic processing circuit is further configured to determine an image stream based on the concentration values.
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公开(公告)号：US20240116984A1
公开(公告)日：2024-04-11
申请号：US18263190
申请日：2022-04-25
IPC分类号： C07K7/06
摘要： Described herein are N-amino peptides (NAPs) that inhibit disease-associated tau aggregation and prevent fibril formation. The NAPs are derived from the R2 and R3 domains of tau (VQIINK and VQIVYK, respectively) wherein the amide moiety is N-aminated. N-amination of the R2 and R3 domains of tau results in formation of soluble mimics of ordered β-strands that are aggregation resistant and can assemble into layered parallel β-sheets.
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公开(公告)号：US11939481B2
公开(公告)日：2024-03-26
申请号：US17357805
申请日：2021-06-24
发明人： Yanliang Zhang , Minxiang Zeng
IPC分类号： C09D11/38 , C09D11/033 , C09D11/037 , C09D11/322 , C09D11/52 , G01J1/42 , B82Y15/00 , B82Y40/00
CPC分类号： C09D11/38 , C09D11/033 , C09D11/037 , C09D11/322 , C09D11/52 , G01J1/42 , B82Y15/00 , B82Y40/00
摘要： Provided are an ink composition, comprising greater than 0.2% by weight a graphene quantum dot nanosurfactant, a printable material, and a solvent, wherein the printable material is dispersed in the solvent by the graphene quantum dot nanosurfactant, and a method of preparing an ink composition. Advantageously, the present ink composition may be printed onto 2D and 3D substrates to form printed films with improved mechanical stability and photoconductance.
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公开(公告)号：US20240088928A1
公开(公告)日：2024-03-14
申请号：US18467212
申请日：2023-09-14
发明人： Jonathan Chisum , Nicolas Garcia , Nicholas Estes
摘要： A device includes a passive antenna configured to capture a signal beam. The example device includes a receiver configured to receive the signal from the antenna, amplify the received signal and output a binary response based on a comparison of the amplified signal to a threshold value. The antenna directs the signal beam to the receiver without consuming power.
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公开(公告)号：US20240010582A1
公开(公告)日：2024-01-11
申请号：US18345908
申请日：2023-06-30
CPC分类号： C07C2/80 , B01J8/0278 , B01J8/0285 , B01J29/48 , B01J2208/00973 , B01J2208/00805 , C07C2529/076
摘要： Exemplary systems and methods process gas streams comprising methane. Exemplary reactors receive a gas stream and comprise catalyst material in a reaction zone. Non-thermal plasma may be generated in the reaction zone. A temperature of the reaction zone may be maintained within a predetermined temperature range. Products may be collected from a reactor outlet.
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10.发明授权公开(公告)号：US11820767B2
公开(公告)日：2023-11-21
申请号：US17135927
申请日：2020-12-28
IPC分类号： C07D471/04 , C07D513/04 , A61P31/00
CPC分类号： C07D471/04 , A61P31/00 , C07D513/04
摘要： Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.
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