公开(公告)号：US20240390055A1

公开(公告)日：2024-11-28

申请号：US18796466

申请日：2024-08-07

Applicant: AngioDynamics, Inc. ,  Virginia Polytechnic Institute and State University

Inventor： Robert M. PEARSON ,  James G. LOVEWELL ,  David WARDEN ,  David Lee MORRISON ,  Tony R. SARNO ,  Hy Truong LAI ,  William C. HAMILTON ,  Rafael Vidal DAVALOS ,  Robert E. NEAL, II

IPC: A61B18/12 ,  A61B18/00 ,  A61B18/14 ,  A61B34/10 ,  A61B34/20

Abstract: A medical system and method for estimating a treatment region for a medical treatment device is provided. The system includes a memory; a processor coupled to the memory; and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region which is an estimate of a treatment region which would have been derived as a result of a numerical model analysis such as a finite element analysis. Advantageously, the estimated treatment region is generated using a fraction of the time it takes to generate the region using the numerical model analysis.

公开(公告)号：US20240366469A1

公开(公告)日：2024-11-07

申请号：US18415117

申请日：2024-01-17

Applicant: CARILION CLINIC ,  VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Tara Newberry ,  Leah Thomas ,  Laura Wenger ,  Seth Jarvis ,  Christopher Arena ,  Andre Muelenaer

IPC: A61H23/02 ,  A61H23/04

Abstract: Devices that can provide a compressive force and a vibratory force to treat an area are described. In some configurations, the devices can include a substrate that can provide the compressive force and multiple independently controllable actuators that can provide the vibratory force to treat swelling, lymphedema or other conditions.

公开(公告)号：US20230220018A1

公开(公告)日：2023-07-13

申请号：US17927082

申请日：2021-05-22

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Glenda Gillaspy ,  Catherine Freed ,  Sarah Phoebe Williams ,  Zhiwu Wang

IPC: C07K14/415 ,  C07K14/39 ,  C12N15/82

CPC classification number: C07K14/415 ,  C07K14/39 ,  C12N15/8261

Abstract: Described herein are engineered cells and plants that contain a heterologous Diadenosine and Diphosphoinositol Polyphosphate Phosphohydrolase (DDP1) polypeptide, a heterologous DDP1 encoding polynucleotide, a vector or vector system comprising a heterologous DDP1 encoding polynucleotide, or a combination thereof. Also described herein are methods of making and using the engineered cells and plants described herein.

公开(公告)号：US20220074770A1

公开(公告)日：2022-03-10

申请号：US17017194

申请日：2020-09-10

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Vasileios KYRITSIS ,  Kevin Todd LOWE ,  Maurice BRISTOW ,  Peter LOFTUS

IPC: G01F1/66

Abstract: A flow machine having a flow passage and an air flow measurement system comprising a plurality of acoustic sensors. The acoustic sensors comprise at least one acoustic transmitter configured to transmit an acoustic waveform through the airflow passing through the flow passage to an acoustic receiver. At least one of the acoustic sensors is rotatable relative to one or more other acoustic sensor.

公开(公告)号：US20210290539A1

公开(公告)日：2021-09-23

申请号：US17264793

申请日：2019-07-30

Applicant: Robert G. GOURDIE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ,  VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Robert G. GOURDIE ,  L. JANE JOURDAN ,  Eda ROGERS

IPC: A61K9/127 ,  C07K14/705 ,  A61K47/46 ,  A61K9/00 ,  A61P17/02 ,  A61P9/06 ,  A61P25/00 ,  A61P27/02 ,  A23C9/152

Abstract: Described herein are engineered hemichannels, engineered vesicles that can contain the one or more of the engineered hemichannels, pharmaceutical formulations thereof, and uses thereof. In some aspects, the engineered vesicles can include one or more cargo molecules. Also described herein are methods of loading the engineered vesicles. In some aspects, loading of one or more cargo molecules engineered vesicles can be optionally via an engineered hemichannel contained in the engineered vesicle.

公开(公告)号：US20180107931A1

公开(公告)日：2018-04-19

申请号：US15842403

申请日：2017-12-14

Applicant: Virginia Polytechnic Institute and State University

Inventor： Christopher L. Barrett ,  Madhav V. Marathe ,  Keith R. Bisset

IPC: G06N5/02 ,  G06Q30/00 ,  G06F17/00 ,  G06Q10/00

CPC classification number: G06N5/022 ,  G06F17/00 ,  G06N5/02 ,  G06Q10/00 ,  G06Q30/00

Abstract: Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further includes receiving a request from a user and determining whether the request can be fulfilled using data currently in the data set. When the request can be fulfilled using data currently in the data set, the data is accessed using broker(s) configured to provide access to data within the data set. When the request cannot be fulfilled using data currently in the data set, at least one new broker is spawned using existing broker(s) and additional data needed to fulfill the request is added to the data set using the new broker. The method further includes generating a response to the request using one or more of the plurality of brokers.

公开(公告)号：US09870531B2

公开(公告)日：2018-01-16

申请号：US15156934

申请日：2016-05-17

Applicant: Virginia Polytechnic Institute and State University

Inventor： Christopher L. Barrett ,  Madhav V. Marathe ,  Keith R. Bisset

IPC: G06F17/00 ,  G06N5/02 ,  G06Q10/00 ,  G06Q30/00

CPC classification number: G06N5/022 ,  G06F17/00 ,  G06N5/02 ,  G06Q10/00 ,  G06Q30/00

Abstract: Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further includes receiving a request from a user and determining whether the request can be fulfilled using data currently in the data set. When the request can be fulfilled using data currently in the data set, the data is accessed using broker(s) configured to provide access to data within the data set. When the request cannot be fulfilled using data currently in the data set, at least one new broker is spawned using existing broker(s) and additional data needed to fulfill the request is added to the data set using the new broker. The method further includes generating a response to the request using one or more of the plurality of brokers.

公开(公告)号：US07753913B2

公开(公告)日：2010-07-13

申请号：US10679166

申请日：2003-10-03

Applicant: David C. Szakelyhidi, Jr. ,  Alex V. Cardinali ,  Joel D. Stitzel ,  Alfred A. Durham ,  Alfred L. Wicks

Inventor： David C. Szakelyhidi, Jr. ,  Alex V. Cardinali ,  Joel D. Stitzel ,  Alfred A. Durham ,  Alfred L. Wicks

IPC: A61B17/58

CPC classification number: A61B5/06 ,  A61B5/062 ,  A61B5/4504 ,  A61B17/1707 ,  A61B17/1725

Abstract: A device and method for targeting objects and specifically for locating intramedullary screw openings is described. The device and method include a target magnet and a sensor comprising an elliptical array of magnetoresistive elements, designed to give information on the three-dimensional orientation of the magnet. The sensor array is designed such that each magnetoresistive element is a member of an opposing pair and relays information on their alignment with the target magnet. The array is connected to a display such that the position of the sensor in relation to the target magnet is easily discerned. The invention is lightweight and portable, capable of operating on batteries and can be used in primitive situations where a stable supply of electricity is not available.

Abstract translation: 描述了用于瞄准物体并且专门用于定位髓内螺钉开口的装置和方法。 该装置和方法包括目标磁体和包括磁阻元件的椭圆阵列的传感器，被设计为提供关于磁体的三维取向的信息。 传感器阵列被设计成使得每个磁阻元件是相对对的构件并且中继其与靶磁体的对准的信息。 阵列连接到显示器，使得传感器相对于目标磁体的位置容易辨别。 本发明轻便且便于携带，能够在电池上操作，并且可以用于不稳定供电的原始情况。

公开(公告)号：US5633793A

公开(公告)日：1997-05-27

申请号：US376365

申请日：1995-01-23

Applicant: Fred C. Lee ,  Yimin Jiang

Inventor： Fred C. Lee ,  Yimin Jiang

IPC: H02M7/21 ,  H02M7/06 ,  H02M7/12 ,  H02M7/219 ,  H02M7/44 ,  H02M7/48 ,  H02M7/5387 ,  H02M7/217

CPC classification number: H02M7/4826 ,  H02M7/062 ,  H02M7/219 ,  H02M7/5387 ,  Y02B70/1441

Abstract: A boost rectifier is provided with an ultra high speed diode in its direct current rail to reduce diode reverse recovery loss with or without implementing a soft switching technique. Full zero-voltage-transition (ZVT) as well as zero-current-transition (ZCT) may also be achieved by adding a simple auxiliary network across the DC rail which operates only during the short turn-on transients of the bridge switches. Similarly, a simple, inexpensive auxiliary circuit can be added to the DC rail of a conventional voltage source inverter shown to implement both ZVT and ZCT.

Abstract translation: 升压整流器在其直流导轨中提供超高速二极管，以减少或不实施软开关技术的二极管反向恢复损耗。 完全零电压转换（ZVT）以及零电流转换（ZCT）也可以通过在仅仅在桥接开关的短接通瞬变期间工作的DC轨道上添加简单的辅助网络来实现。 类似地，可以将简单，便宜的辅助电路添加到所示的常规电压源逆变器的DC导轨上，以实现ZVT和ZCT。

公开(公告)号：US5574636A

公开(公告)日：1996-11-12

申请号：US304661

申请日：1994-09-09

Applicant: Fred C. Lee ,  Hengchun Mao

Inventor： Fred C. Lee ,  Hengchun Mao

IPC: H02M7/219 ,  H02M5/458 ,  H02M7/12 ,  H02M7/48 ,  H02M7/5387

CPC classification number: H02M5/4585 ,  H02M7/4826 ,  Y02B70/145

Abstract: An improved zero voltage transition (ZVT) pulse width modulation (PWM) link converter is provided which introduces a space vector modulation scheme and an auxiliary circuit which includes a commutation power supply or special switch arrangement used to discharge resonant inductor currents to zero and to recover commutation energy. In an alternate embodiment, an improved ZVT PWM link converter provides an auxiliary switch for each main switch in the converter to achieve ZVT. The novel ZVT converters provide zero-voltage switching without increasing switching action of the main switches. In this way, the advantages of PWM control is maintained. Conduction loss, turn-off losses, and voltage stress of the main switches are the same as in conventional PWM converters, but the dominant turn-on losses are eliminated, so total power losses are minimized.

Abstract translation: 提供了一种改进的零电压转换（ZVT）脉宽调制（PWM）链路转换器，其引入空间矢量调制方案和辅助电路，其包括用于将谐振电感器电流放电到零并且恢复的换向电源或特殊开关装置 换向能量 在替代实施例中，改进的ZVT PWM链路转换器为转换器中的每个主开关提供辅助开关以实现ZVT。 新型ZVT转换器提供零电压开关，而不增加主开关的开关动作。 以这种方式，可以保持PWM控制的优点。 主开关的导通损耗，关断损耗和电压应力与传统PWM转换器相同，但主导导通损耗被消除，因此总功率损耗最小化。