公开(公告)号：US10017475B2

公开(公告)日：2018-07-10

申请号：US15129785

申请日：2015-03-26

申请人： XAVIER UNIVERSITY OF LOUISIANA

发明人： Guangdi Wang ,  Shilong Zheng ,  Qiu Zhong ,  Qiang Zhang

IPC分类号： A61K31/4418 ,  C07D213/61 ,  A61K45/06 ,  C07D213/30 ,  A61K31/4425

CPC分类号： C07D213/61 ,  A61K31/4418 ,  A61K31/4425 ,  A61K45/06 ,  C07D213/30

摘要： Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the combretastatin analog compounds and uses of the combretastatin analog compounds, either alone or in combination with at least one additional therapeutic agent, in the treatment of cancer, and in particular cancer presenting as metastatic tumors.

公开(公告)号：US20210284663A1

公开(公告)日：2021-09-16

申请号：US16463135

申请日：2017-11-22

申请人： XAVIER UNIVERSITY OF LOUSIANA

发明人： Guangdi WANG ,  Jiawang LIU ,  Shilong ZHENG ,  Shanchun GUO

IPC分类号： C07F5/02 ,  C07C255/60 ,  C07C235/56

摘要： The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferative diseases, including cancer, particularly prostate cancer, and especially castration-resistant prostate cancer.