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公开(公告)号：US10512672B2
公开(公告)日：2019-12-24
申请号：US14905915
申请日：2014-07-17
摘要： This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
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公开(公告)号：US20220313785A1
公开(公告)日：2022-10-06
申请号：US17845101
申请日：2022-06-21
摘要： This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
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公开(公告)号：US20230203053A1
公开(公告)日：2023-06-29
申请号：US17962187
申请日：2022-10-07
发明人： Raymond A. Chavez , Stephen Collins
IPC分类号： C07D489/00 , A61P25/02 , A61P25/04
CPC分类号： C07D489/00 , A61P25/02 , A61P25/04 , C07B2200/07
摘要： The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.
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公开(公告)号：US20240352089A1
公开(公告)日：2024-10-24
申请号：US18648678
申请日：2024-04-29
IPC分类号： C07K14/715 , A61K9/00 , A61K35/17 , A61K35/30 , A61K38/17 , A61K38/20 , A61P25/00 , C07K14/54 , C12N7/00
CPC分类号： C07K14/7155 , A61K9/0085 , A61K35/17 , A61K35/30 , A61K38/1793 , A61K38/2066 , A61P25/00 , C07K14/5428 , C12N7/00 , C12N2740/15043 , C12N2750/14143
摘要： This invention relates to methods and compositions for overcoming the dose-dependent down regulation of interleukin 10 (IL-10) by expressing, in addition to an interleukin 10 (IL-10) peptide, an IL-10 receptor type 1 (IL-10R1) peptide. The methods have use in treating a variety of diseases and symptoms, including but not limited to neuropathic or chronic pain; symptoms and physiological damage associated with multiple sclerosis, spinal cord injury, ALS, neuroinflammation, arthritis and other diseases of the joint; and autoimmune diseases.
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公开(公告)号：US20210087202A1
公开(公告)日：2021-03-25
申请号：US16772108
申请日：2018-12-12
发明人： Raymond A. Chavez , Stephen Collins
IPC分类号： C07D489/00 , A61P25/02 , A61P25/04
摘要： The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.
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公开(公告)号：US20230158114A1
公开(公告)日：2023-05-25
申请号：US18159161
申请日：2023-01-25
CPC分类号： A61K38/2066 , A61K48/005 , C07K14/5428 , A61K48/0075 , A61K48/0091
摘要： This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
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公开(公告)号：US11505556B2
公开(公告)日：2022-11-22
申请号：US16772108
申请日：2018-12-12
发明人： Raymond A. Chavez , Stephen Collins
IPC分类号： C07D489/00 , A61K31/485 , A61P25/02 , A61P25/04
摘要： The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.
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公开(公告)号：US20200093892A1
公开(公告)日：2020-03-26
申请号：US16670987
申请日：2019-10-31
摘要： This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
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