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    Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders
    3.
    发明申请
    Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders 审中-公开
    用于检测和治疗阿尔茨海默病和相关疾病的化合物和组合物

    公开(公告)号：US20150098903A1

    公开(公告)日：2015-04-09

    申请号：US14569855

    申请日：2014-12-15

    申请人： The General Hospital Corporation ,  Fluoropharma, Inc.

    发明人： David R. Elmaleh ,  Timothy M. Shoup ,  Hongning Fu

    IPC分类号： C07C43/253 ,  C07C43/192 ,  A61K51/04 ,  C07C43/196

    CPC分类号： A61K51/0497 ,  C07C43/192 ,  C07C43/196 ,  C07C43/253 ,  C07D471/10 ,  C07H13/02 ,  C07H13/10 ,  C07H15/26

    摘要： One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

    摘要翻译： 本发明的一个方面涉及用于诊断和/或治疗患有淀粉样变性相关病理状况的受试者的化合物，组合物和方法。 在某些实施方案中，本发明的成像和/或治疗剂可以施用于受试者以鉴定和/或治疗淀粉样沉积物。 具体的成像方法通过对受试者施用成像剂并检测试剂的空间分布来检测淀粉样蛋白沉积物。 药剂的差异积累是AD或淀粉样变性相关病理状态的指示，并且可以通过使用PET或SPECT照相机进行监测。

    FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS
    4.
    发明申请
    FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS 有权
    ARYL，HETEROARYL，O-ARYL和O-HETEROARYL CARBASUGARS家族

    公开(公告)号：US20140105839A1

    公开(公告)日：2014-04-17

    申请号：US14119265

    申请日：2012-05-29

    申请人： Geraldine Deliencourt-Godefroy ,  Lenaig Lopes

    发明人： Geraldine Deliencourt-Godefroy ,  Lenaig Lopes

    IPC分类号： C07C43/29 ,  C07D333/16 ,  A61K8/34 ,  A61Q19/02 ,  C07C41/24 ,  C07C43/253 ,  C07C43/225 ,  C07C41/22 ,  C07C41/09 ,  C07D231/20 ,  A61K8/49

    CPC分类号： C07C43/29 ,  A61K8/347 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/4986 ,  A61K8/69 ,  A61Q19/02 ,  C07C41/09 ,  C07C41/22 ,  C07C41/24 ,  C07C43/225 ,  C07C43/23 ,  C07C43/247 ,  C07C43/253 ,  C07D231/20 ,  C07D333/16

    摘要： The present invention relates to a compound of the following formula (I): as well as its process of preparation, pharmaceutical and cosmetics composition comprising it and use thereof, notably as an inhibitor of the sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, in particular in the treatment or prevention of diabetes, and more particularly type-II diabetes, diabetes-related complications, such as arthritis of the lower extremities, cardiac infarction, renal insufficiency, neuropathy or blindness, hyperglycemia, hyperinsulinemia, obesity, hypertriglyceridemia, X syndrome and arteriosclerosis, as well as for its use as an anticancer, anti-infective, anti-viral, anti-thrombotic or anti-inflammatory drug, or for lightening, bleaching, depigmenting the skin, removing blemishes from the skin, particularly age spots and freckles, or preventing pigmentation of the skin.

    摘要翻译： 本发明涉及以下式（I）的化合物及其制备方法，包含其的药物和化妆品组合物及其用途，特别是作为钠依赖型葡萄糖共转运体的抑制剂，例如SGLT1 特别是糖尿病的治疗或预防，特别是II型糖尿病，糖尿病相关并发症如下肢关节炎，心肌梗塞，肾功能不全，神经病变或失明，高血糖症，高胰岛素血症， 肥胖症，高甘油三酯血症，X综合征和动脉硬化，以及其用作抗癌，抗感染，抗病毒，抗血栓形成或抗炎药物，或用于减轻，漂白，脱色皮肤，从 皮肤，特别是老年斑和雀斑，或防止皮肤色素沉着。

    Phenyl-substituted cycloalkenyl compounds useful as PDE IV inhibitors
    8.
    发明授权
    Phenyl-substituted cycloalkenyl compounds useful as PDE IV inhibitors 失效
    可用作PDE IV抑制剂的苯基取代的环烯基化合物

    公开(公告)号：US5362915A

    公开(公告)日：1994-11-08

    申请号：US934546

    申请日：1992-10-02

    申请人： Harald Maschler ,  Siegfried B. Christensen, IV

    发明人： Harald Maschler ,  Siegfried B. Christensen, IV

    IPC分类号： A61K31/09 ,  A61K31/10 ,  A61K31/34 ,  A61K31/341 ,  A61P7/06 ,  A61P9/00 ,  A61P11/00 ,  A61P25/28 ,  A61P43/00 ,  C07C43/21 ,  C07C43/235 ,  C07C43/243 ,  C07C43/247 ,  C07C43/253 ,  C07C45/62 ,  C07C45/68 ,  C07C49/753 ,  C07C317/22 ,  C07C323/20 ,  C07D307/20 ,  C07C43/205 ,  A61K31/075

    CPC分类号： C07C49/753 ,  C07C43/21 ,  C07C43/235 ,  C07C43/243 ,  C07C43/247 ,  C07C43/253 ,  C07C45/62 ,  C07C45/68 ,  C07C2101/08 ,  C07C2101/10 ,  C07C2101/14

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 to 3 fluorines;X is O or S(O).sub.s where s=0 to 2;R.sub.2 is C.sub.4 -C.sub.6 cyclic alkyl, optionally substituted by one to three methyl groups or one ethyl group; --CH.sub.2 -cyclopentyl, --CH.sub.2 -cyclopropyl, 3-tetrahydrofuranyl, C.sub.1-7 alkyl, CH.sub.3 or CH.sub.2 CH.sub.3 substituted by one to three fluorines;--(CH.sub.2).sub.n COO(CH.sub.2).sub.g CH.sub.3, or (CH.sub.2).sub.n O(CH.sub.2).sub.g CH.sub.3, wherein n is 2 to 4 and g is 0 to 2;R.sub.3 represents a moiety of formula (a); ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen or R.sub.4 and R.sub.5 together represent a bond;B represents >C.dbd.O, >C.dbd.S or >CH--R.sub.6 wherein R.sub.6 represents H, OH, C.sub.1-6 alkoxy or C.sub.1-6 thioalkoxy; and m and r each independently represents zero or an integer in the range of 1 to 4 wherein m+r represents an integer in the range of from 2 to 4; with the proviso that when R.sub.1 is methyl, X is oxygen, R.sub.2 is methyl or cyclopenyl, R.sub.3 does not represent cyclopent-1,2-ene-3-one.

    摘要翻译： PCT No.PCT / EP91 / 00637 371日期：1992年10月2日 102（e）日期1992年10月2日PCT 1991年4月2日PCT PCT。 公开号WO91 / 15451 （I）化合物或其药学上可接受的盐：其中：R 1为-CH 3或-CH 2 CH 3，未被取代或被1至3个氟取代; X是O或S（O）s，其中s = 0至2; R2是C4-C6环烷基，任选被一至三个甲基或一个乙基取代; -CH2-环戊基，-CH 2 - 环丙基，3-四氢呋喃基，C 1-7烷基，被一至三个氟取代的CH 3或CH 2 CH 3; - （CH 2）n COO（CH 2）g CH 3或（CH 2）n O（CH 2）g CH 3，其中n为2至4，g为0至2; R3表示式（a）的部分; （a）其中R4和R5各自表示氢或R4和R5一起表示键; B表示C = O，> C = S或> CH-R6，其中R6表示H，OH，C1-6烷氧基或C1-6硫代烷氧基; m和r各自独立地表示0或1〜4的整数，其中m + r表示2〜4的整数; 条件是当R 1是甲基时，X是氧，R 2是甲基或环烯基，R 3不代表环戊基-1,2-庚-3-酮。

    Process for forming photographic images
    10.
    发明授权
    Process for forming photographic images 失效
    用于形成摄影图像的过程

    公开(公告)号：US4419439A

    公开(公告)日：1983-12-06

    申请号：US322053

    申请日：1981-11-16

    申请人： Shigeru Kuwazima ,  Eiichi Kato ,  Minoru Yamada

    发明人： Shigeru Kuwazima ,  Eiichi Kato ,  Minoru Yamada

    IPC分类号： G03C1/00 ,  C07C43/23 ,  C07C43/253 ,  G03C1/06 ,  G03C1/42 ,  G03C7/30 ,  G03C7/00

    CPC分类号： G03C7/3003 ,  C07C43/23 ,  C07C43/253 ,  G03C1/42 ,  G03C2007/3025

    摘要： A process for forming a photographic image comprising imagewise exposing a silver halide photographic light-sensitive material to light and processing the silver halide photographic light-sensitive material with an alkaline processing solution, wherein the improvement comprises the silver halide photographic light-sensitive material contains a compound represented by formula (I) ##STR1## wherein R represents an alkyl group having from 6 to 22 carbon atoms, a substituted alkyl group having from 6 to 22 carbon atoms, an aryl group having from 6 to 22 carbon atoms, a substituted aryl group having from 6 to 22 carbon atoms, an alkenyl group having from 6 to 22 carbon atoms, a substituted alkenyl group having from 6 to 22 carbon atoms or an aralkyl group having from 7 to 22 carbon atoms; X represents an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, or a halogen atom; and n represents an integer from 1 to 3.According to the process, a high maximum image density is obtained using a silver halide photographic light-sensitive material containing a low amount of coated silver.

    摘要翻译： 一种用于形成摄影图像的方法，包括将卤化银摄影感光材料成像曝光于光并用碱性处理溶液处理卤化银摄影感光材料，其中改进包括卤化银照相感光材料含有 由式（I）表示的化合物其中R表示具有6至22个碳原子的烷基，具有6至22个碳原子的取代烷基，具有6至22个碳原子的芳基， 具有6至22个碳原子的取代的芳基，具有6至22个碳原子的烯基，具有6至22个碳原子的取代的烯基或具有7至22个碳原子的芳烷基; X表示具有1至4个碳原子的烷基，具有1至6个碳原子的烷氧基或卤素原子; 并且n表示1至3的整数。根据该方法，使用含有少量涂覆的银的卤化银照相感光材料获得高的最大图像浓度。