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    DUAL CATALYST SYSTEM FOR MASS VINYL ADDITION AND CATIONIC POLYMERIZABLE COMPOSITIONS
    1.
    发明公开
    DUAL CATALYST SYSTEM FOR MASS VINYL ADDITION AND CATIONIC POLYMERIZABLE COMPOSITIONS 审中-公开

    公开(公告)号：US20230265243A1

    公开(公告)日：2023-08-24

    申请号：US18110906

    申请日：2023-02-17

    申请人： PROMERUS, LLC

    发明人： GUODONG DENG

    IPC分类号： C08G65/12 ,  C08K5/55 ,  C08G65/26 ,  C08K5/45 ,  B01J31/12

    CPC分类号： C08G65/12 ,  C08K5/55 ,  C08G65/266 ,  C08K5/45 ,  B01J31/12 ,  C08G2650/16 ,  C08G2650/24 ,  C08G2650/58

    摘要： Embodiments in accordance with the present invention encompass compositions comprising an organopalladium compound, a photoacid generator, a photosensitizer, one or more epoxy group containing olefinic monomers. The compositions of this invention may additionally contain one or more olefinic monomers and a stabilizer, such as for example a hindered amine. The compositions undergo simultaneous vinyl addition polymerization and cationic polymerization when exposed to a suitable actinic radiation to form a substantially transparent film. The compositions of this invention are stable at room temperature for several days to several months and undergo mass polymerization only when subjected to suitable actinic radiation. The monomers employed therein have a range of optical and mechanical properties, and thus these compositions can be tailored to form films having various opto-electronic properties. More specifically, the compositions of this invention undergo much faster mass polymerization and exhibit superior thermo-mechanical properties when compared with the compositions containing only the olefinic monomers. Accordingly, compositions of this invention are useful in various applications, including as coatings, encapsulants, fillers, leveling agents, sealants, adhesives, among others.

    MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVES, CONJUGATES AND GELS OF PHARMACEUTICALS AND THE SAME
    5.
    发明申请
    MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVES, CONJUGATES AND GELS OF PHARMACEUTICALS AND THE SAME 审中-公开
    多臂聚乙烯衍生物，药物与其相同的凝胶和凝胶

    公开(公告)号：US20140135486A1

    公开(公告)日：2014-05-15

    申请号：US14160167

    申请日：2014-01-21

    申请人： JENKEM TECHNOLOGY CO., LTD, TIANJIN BRANCH

    发明人： Xuan Zhao ,  Meina Lin

    IPC分类号： A61K47/48 ,  A61K31/727

    CPC分类号： A61K31/727 ,  A61K47/60 ,  A61K47/6903 ,  C08G65/2609 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33337 ,  C08G2650/24 ,  C08L2203/02

    摘要： A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m—, the average value of m is an integer of 2-250; l is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.

    摘要翻译： 公开了具有不同种类的反应性基团的多臂聚乙二醇（I）及其用途，其通过将环氧乙烷与低聚季戊四醇作为引发剂聚合形成，其中PEG相同或不同，为 - （CH 2 CH 2 O） m-，m的平均值为2-250的整数; l为1以上的整数。 制备具有不同反应性基团的多臂聚乙二醇的方法，包括连接到PEG的连接基团X和连接到X的末端反应性基团F的多臂聚乙二醇活性衍生物，由多臂聚乙烯形成的凝胶 乙二醇活性衍生物，由多臂聚乙二醇活性衍生物和药物分子形成的药物缀合物及其在制备药物中的用途。

    Multi-arm block copolymers as drug delivery vehicles
    6.
    发明授权
    Multi-arm block copolymers as drug delivery vehicles 有权

    公开(公告)号：US08586681B2

    公开(公告)日：2013-11-19

    申请号：US13680953

    申请日：2012-11-19

    申请人： Nektar Therapeutics

    发明人： Xuan Zhao

    IPC分类号： C08F283/00 ,  C08G63/91

    CPC分类号： C08G63/914 ,  A61K31/724 ,  A61K31/74 ,  A61K31/77 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6949 ,  B82Y5/00 ,  C08G65/2609 ,  C08G81/00 ,  C08G2650/24 ,  C08L71/02 ,  C08L2205/05 ,  C08L2666/18

    摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.

    NOVEL COMPOUNDS
    8.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：US20120282201A1

    公开(公告)日：2012-11-08

    申请号：US13508158

    申请日：2010-12-08

    申请人： Alexander Schlifke-Poschalko

    发明人： Alexander Schlifke-Poschalko

    IPC分类号： C07C69/734 ,  A61Q17/04 ,  C07C67/08 ,  A61K8/90

    CPC分类号： A61Q17/04 ,  A61K8/86 ,  C08G65/22 ,  C08G65/3326 ,  C08G2261/122 ,  C08G2650/24 ,  C08L71/02 ,  C08L2205/05

    摘要： The invention relates to novel polyglycerol based UV-filters as well as to topical compositions comprising such novel polyglycerol based UV-filters. Furthermore, the invention relates to the use of such novel polyglycerol based UV-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils.

    摘要翻译： 本发明涉及新型的基于聚甘油的UV-过滤器以及包含这种新型聚甘油基UV-过滤器的局部组合物。 此外，本发明涉及这种新型聚甘油基紫外线过滤器用于增强丁基甲氧基二苯甲酰基甲烷或双 - 乙基己氧基苯酚甲氧基苯基三嗪在化妆品油中的溶解度的用途。

    Multi-arm block copolymers as drug delivery vehicles
    9.
    发明授权
    Multi-arm block copolymers as drug delivery vehicles 有权
    多臂嵌段共聚物作为药物输送载体

    公开(公告)号：US08071692B2

    公开(公告)日：2011-12-06

    申请号：US12538013

    申请日：2009-08-07

    申请人： Xuan Zhao

    发明人： Xuan Zhao

    IPC分类号： C08F283/00 ,  C08G63/91

    CPC分类号： C08G63/914 ,  A61K31/724 ,  A61K31/74 ,  A61K31/77 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6949 ,  B82Y5/00 ,  C08G65/2609 ,  C08G81/00 ,  C08G2650/24 ,  C08L71/02 ,  C08L2205/05 ,  C08L2666/18

    摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.

    摘要翻译： 本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。 多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段 和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。 疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。 本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。