公开(公告)号：US20170115303A1

公开(公告)日：2017-04-27

申请号：US15331745

申请日：2016-10-21

Applicant: The Scripps Research Institute

Inventor： Benjamin F. CRAVATT ,  Keriann M. BACKUS ,  Bruno E. CORREIA ,  Megan M. BLEWETT ,  John R. TEIJARO

IPC: G01N33/68 ,  G01N33/50 ,  C12N9/10 ,  C12N9/64 ,  C12N9/04

CPC classification number: G01N33/6845 ,  C12N9/0006 ,  C12N9/1007 ,  C12N9/6472 ,  C12Y101/01042 ,  C12Y201/01023 ,  C12Y304/22061 ,  C12Y304/22063 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/6842

Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.