公开(公告)号：US20050037450A1

公开(公告)日：2005-02-17

申请号：US10635265

申请日：2003-08-06

申请人： John York ,  Bryan Spiegelberg

发明人： John York ,  Bryan Spiegelberg

IPC分类号： C12N9/00 ,  C12N9/16 ,  C12Q1/42

CPC分类号： C12Y301/03007 ,  C12N9/00 ,  C12N9/16 ,  C12Q1/42

摘要： Compounds for use as lithium-like therapeutic agents and methods and reagents for identifying same as well as compounds for treating lithium-induced toxicity and methods and reagents for identifying same. The compounds modulate the activity of enzymes within pathways upon which lithium has been discovered to act. Also disclosed herein are transgenic animals that serve as models of lithium-induced toxicity and methods of using the transgenic animals for identifying compounds that ameliorate lithium toxicity. Furthermore, disclosed herein are methods of modeling target sites for lithium.

摘要翻译： 用作类锂治疗剂的化合物和用于鉴定其的方法和试剂以及用于治疗锂诱导的毒性的化合物以及用于鉴定其的方法和试剂。 该化合物调节已被发现锂作用的通路内酶的活性。 本文还公开了用作锂诱导毒性模型的转基因动物和使用转基因动物鉴定改善锂毒性的化合物的方法。 此外，本文公开了对锂的靶位点进行建模的方法。

公开(公告)号：US20180355369A1

公开(公告)日：2018-12-13

申请号：US15741084

申请日：2016-06-30

申请人： The Australian National University

发明人： Barry James Pogson ,  Gonzalo Martin Estavillo ,  Kai Xun Chan ,  Su Yin Phua ,  Peter Alexander Crisp

IPC分类号： C12N15/82 ,  C12N9/16

CPC分类号： C12N15/8271 ,  A01H3/04 ,  A01N57/16 ,  C12N9/14 ,  C12N9/16 ,  C12N9/22 ,  C12N15/8261 ,  C12N15/8267 ,  C12N15/8269 ,  C12N15/8273 ,  C12Y301/03007

摘要： The present invention provides a method for increasing the levels of 3′-phosphoadenosine-5′-phosphate (PAP) or a derivative or analogue thereof in cells of said plant compared to an untreated or wild-type plant grown under the same stress conditions. The methods may comprise administration to the plant and/or the soil it is growing in of: PAP or a derivative or analogue thereof, a substance that enhances or promotes synthesis or accumulation of PAP or said derivative or analogue thereof; or a substance that inhibits or compromises an activity metabolising or removing PAP or said derivative or analogue thereof. Alternatively, the methods may comprise genetic modification of cells of said plant which modifications allow for increased accumulation of PAP or a derivative or analogue thereof in cells of said plant (or in seeds thereof) at least under stress conditions compared to a wild-type plant. The methods find particular application in increasing the tolerance of plants to abiotic stress conditions, which may be selected from increased salinity, increased sodium levels, drought, light stress and pH stress. The present invention also provides a method for extending the dormancy of a seed, as compared to an untreated seed, said method comprising accumulating in cells within said seed an increased level of PAP or a derivative or analogue thereof compared to an untreated or wild-type seed.

公开(公告)号：US12104193B2

公开(公告)日：2024-10-01

申请号：US17132270

申请日：2020-12-23

申请人： AJINOMOTO CO., INC.

发明人： Sergey Vasilievich Smirnov ,  Irina Lvovna Tokmakova

IPC分类号： C12P19/26 ,  C12N9/10 ,  C12N9/16 ,  C12N15/52

CPC分类号： C12P19/26 ,  C12N9/13 ,  C12N9/16 ,  C12N15/52 ,  C12Y208/02001 ,  C12Y208/02008 ,  C12Y301/03002 ,  C12Y301/03007

摘要： A method for enzymatic sulfurylation of a substrate is provided which includes the steps of reacting the substrate with 3′-phosphoadenosine-5′-phosphosulfate (PAPS) in a medium containing a bacterium belonging to the family Enterobacteriaceae to produce a sulfated derivative of the substrate, and collecting the sulfated derivative from the medium, wherein the bacterium has been modified to produce, at least, a protein having sulfotransferase activity, and to attenuate expression of an aphA gene, a cysQ gene, or a cpdB gene, or a combination of these.