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1.发明授权Compositions and methods for detecting juvenile renal dysplasia or calcium oxalate stones in dogs 有权用于检测狗中幼年肾发育不良或草酸钙结石的组合物和方法公开(公告)号：US08945831B2
公开(公告)日：2015-02-03
申请号：US12864065
申请日：2009-01-22
申请人： Mary Helen Whiteley
发明人： Mary Helen Whiteley
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/124 , C12Q2600/156 , C12Q2600/158 , G01N2333/90274 , G01N2800/347 , Y10T436/143333
摘要： The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing Juvenile Renal Dysplasia or calcium oxalate stones.
摘要翻译： 本申请涉及与少年肾发育不良相关的犬Cox2等位变体，引物和探针组合物以及可用于检测，监测和诊断少年肾发育不良或草酸钙结石的方法和试剂盒。
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公开(公告)号：US20240360510A1
公开(公告)日：2024-10-31
申请号：US18563450
申请日：2022-05-24
申请人： UNIVERSITE PARIS-SACLAY , INSERM (Institut National de la Santé et de la Recherche Médicale) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL
IPC分类号： C12Q1/6883 , A61K45/00 , G01N33/68
CPC分类号： C12Q1/6883 , A61K45/00 , G01N33/6893 , C12Q2600/156 , G01N2333/90274 , G01N2800/04 , G01N2800/50
摘要： The present results show that KDM1A is a key epigenetic regulator of tissue-specific expression of GIP receptor and possibly of other receptors from the G-protein coupled receptor family in hormone-producing glands, and that its alteration leads to the development of aberrant overexpression of eutopic hormone receptors or expression of ectopic hormone receptors that lead to abnormal steroidogenesis. They also show that loss of expression of KDM1A is likely to be the initiating event that trigger the abnormal cell proliferation leading to the development of tissue lesions in adrenal and possibly in other endocrine tissues (notably in the adrenal glands). The present invention therefore proposes to detect altered expression of KDM1A in the genome of subjects, in order to diagnose a genetic predisposition to an endocrine disease and/or to an endocrine hyperplasia. On another hand, the present results suggest that the physiological eutopic GIP receptor expression in the pancreas may be also epigenetically regulated by KDM1A. This expression could be pharmacologically targeted by KDM1A inhibitors so as to treat patients suffering from diabetes mellitus and other metabolic diseases.
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3.发明申请Compositions and Methods for Detecting Juvenile Renal Dysplasia or Calcium Oxalate Stones in Dogs 有权检测狗中少年肾发育不良或草酸钙的组合物和方法公开(公告)号：US20100311071A1
公开(公告)日：2010-12-09
申请号：US12864065
申请日：2009-01-22
申请人： Mary Helen Whiteley
发明人： Mary Helen Whiteley
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/124 , C12Q2600/156 , C12Q2600/158 , G01N2333/90274 , G01N2800/347 , Y10T436/143333
摘要： The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing Juvenile Renal Dysplasia or calcium oxalate stones.
摘要翻译： 本申请涉及与少年肾发育不良相关的犬Cox2等位变体，引物和探针组合物以及可用于检测，监测和诊断少年肾发育不良或草酸钙结石的方法和试剂盒。
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公开(公告)号：US5888982A
公开(公告)日：1999-03-30
申请号：US831475
申请日：1997-03-31
申请人： Mark A. Perrella , Mu-En Lee
发明人： Mark A. Perrella , Mu-En Lee
CPC分类号： C12N9/0083 , C12Q1/26 , C12Q1/6897 , A01K2217/05 , A61K38/00 , G01N2333/90245 , G01N2333/90258 , G01N2333/90274 , G01N2500/10
摘要： The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.
摘要翻译： 本发明的特征在于一种抑制哺乳动物脓毒症相关性低血压的方法，其包括鉴定患有或有罹患败血症危险的哺乳动物并向哺乳动物施用抑制诱导型血红素加氧酶（HO-1）表达的化合物的步骤。 还公开了用于鉴定能够抑制HO-1表达或酶活性的化合物的筛选分析。
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