公开(公告)号：US06918869B2

公开(公告)日：2005-07-19

申请号：US10307917

申请日：2002-12-02

申请人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

发明人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

IPC分类号： A61B17/22 ,  A61B18/02 ,  A61B18/04 ,  A61K9/00 ,  A61K9/22 ,  A61N5/10 ,  A61N5/00 ,  A61B9/22

CPC分类号： A61K9/0024 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/046 ,  A61F2/82 ,  A61N5/1002

摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.