公开(公告)号：US06596773B2

公开(公告)日：2003-07-22

申请号：US10051699

申请日：2002-01-17

申请人： Michael Bös ,  Guido Galley ,  Thierry Godel ,  Torsten Hoffmann ,  Walter Hunkeler ,  Patrick Schnider ,  Heinz Stadler

发明人： Michael Bös ,  Guido Galley ,  Thierry Godel ,  Torsten Hoffmann ,  Walter Hunkeler ,  Patrick Schnider ,  Heinz Stadler

IPC分类号： A61K3167

CPC分类号： C07D213/75 ,  C07C233/29 ,  C07C233/33 ,  C07C233/44 ,  C07C317/40 ,  C07C323/41 ,  C07D295/135

摘要： The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK-1 receptor.

公开(公告)号：US06632807B1

公开(公告)日：2003-10-14

申请号：US09635067

申请日：2000-08-09

申请人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

发明人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

IPC分类号： A61K3167

CPC分类号： C07D495/04 ,  C07F9/6561 ,  C07F9/657181

摘要： This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.

摘要翻译： 本发明涉及由下式表示的光学活性苯并硫代衍生物：其中R代表低级烷基; R <1 和R <2 独立地表示低级烷基，或者可以结合在一起形成环，其显示出优异的成骨促进作用 并且可用作骨疾病的预防或治疗药物

公开(公告)号：US06599889B2

公开(公告)日：2003-07-29

申请号：US09797308

申请日：2001-03-01

申请人： Jeffrey M. Besterman ,  Jubrail Rahil ,  Rex Pratt

发明人： Jeffrey M. Besterman ,  Jubrail Rahil ,  Rex Pratt

IPC分类号： A61K3167

CPC分类号： C07F9/65744 ,  C07F9/096 ,  C07F9/098 ,  C07F9/4093 ,  C07F9/657181 ,  C07F9/65742

摘要： The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.

公开(公告)号：US06346521B1

公开(公告)日：2002-02-12

申请号：US08579731

申请日：1995-12-28

申请人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

发明人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

IPC分类号： A61K3167

CPC分类号： C07D495/04 ,  C07F9/6561 ,  C07F9/657181

摘要： This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.

摘要翻译： 本发明涉及由下式表示的光学活性苯并硫代衍生物：其中R代表低级烷基; R1和R2独立地表示低级烷基，或者可以结合在一起形成环，其表现出优异的成骨促进作用，并且可用作骨疾病的预防或治疗药物。