公开(公告)号：US06248778B1

公开(公告)日：2001-06-19

申请号：US09492004

申请日：2000-01-27

申请人： Rolf Gebhardt

发明人： Rolf Gebhardt

IPC分类号： A61K335

CPC分类号： A61K31/352

摘要： The invention relates to a drug for treating or preventing intrahepatic cholestasis, which is characterized by containing as active agent at least one compound with the general formula I, where R, R1 and R2 are independent of each other and can each ═H, C1-2-alkyl or C1-3-acyl, R3═H or OR4 and R4═H, C1-2-alkyl or C1-4-acyl, and there is a single or double bond between positions 2 and 3, or a physiologically acceptable salt thereof.

摘要翻译： 本发明涉及治疗或预防肝内胆汁淤积的药物，其特征在于含有至少一种具有通式I的化合物作为活性剂，其中R，R 1和R 2彼此独立，并且各自可以是H，C1- 2-烷基或C 1-3 - 酰基，R 3 = H或OR 4和R 4 = H，C 1-2 - 烷基或C 1-4 - 酰基，并且在位置2和3之间存在单键或双键，或生理上可接受的 的盐。

公开(公告)号：US06589983B1

公开(公告)日：2003-07-08

申请号：US10048026

申请日：2002-03-29

申请人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

发明人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

IPC分类号： A61K335

CPC分类号： C07D405/12 ,  C07D311/68 ,  C07D311/70

摘要： This invention relates a benzopyran denvative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a (substituted)C1-6 alkyl group or a (substituted)phenyl group,R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents a hydrogen atom, or R3 and R4 together form a bond, m represents an integer of 0-4, n represents an integer of 0-4, Y is absent, or represents CR11R12 in which R11 and R12 represent each independently a hydrogen atom or a C1-6 alkyl group, R5 represents an aryl group or a (substituted)heteroaryl group,R6 represents a hydrogen atom or a C1-6 alkyl group,R7 represents a hydrogen atom or a C1-6 alkyl group,X is absent, or represents C=O or SO2, R8 represents a hydrogen atom, a (substituted)C1-6 alkyl group or C3-6 cycloalkyl group, and R9 represents a nitro group, etc., or a pharmaceutically acceptable salt thereof. And this invention also relates an antiarrhythmic agent having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 本发明涉及式（I）的苯并吡喃类抗坏血酸，其中R1和R2各自独立地表示氢原子，（取代的）C1-6烷基或（取代的）苯基，R3表示羟基或C1-6烷基羰氧基 基团，R4表示氢原子，或R3和R4一起形成键，m表示0-4的整数，n表示0-4的整数，Y不存在，或表示其中R 11和R 12各自独立地表示的CR 11 R 12 氢原子或C1-6烷基，R5表示芳基或（取代）杂芳基，R6表示氢原子或C1-6烷基，R7表示氢原子或C1-6烷基， X不存在，或表示C = O或SO 2，R 8表示氢原子，（取代的）C 1-6烷基或C 3-6环烷基，R 9表示硝基等，或其药学上可接受的盐 。 本发明还涉及具有作为活性成分的所述化合物或其药学上可接受的盐具有对功能不应期的延长作用的抗心律失常药。