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公开(公告)号:US06555574B1
公开(公告)日:2003-04-29
申请号:US10049996
申请日:2002-03-29
申请人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号: A61K3135
CPC分类号: C07D405/12 , C07D311/22
摘要: This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or a C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, an aryl group or a heteroaryl group; n represents an integer of 0-4; X represents —C(═O)NR7—, —NR8—, —NHC(═O)NH— or —S(O)2NH—; R5 represents a hydrogen atom or (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l); R6 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to an antiarrhythmic agent having the prolongation effect of the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译: 本发明涉及式(I)的4-氧代苯并吡喃衍生物,其中R1和R2各自独立地表示氢原子,C1-6烷基或苯基; R3表示羟基或C1-6烷基羰基氧基; R 4表示氢原子,C 3-6环烷基,C 1-6烷基,C 1-6烷基羰基,C 1-6烷基氨基羰基,二-C 1-6烷基氨基羰基,芳基或杂芳基 ; n表示0-4的整数; X表示-C(= O)NR 7 - , - NR 8 - , - NHC(= O)NH-或-S(O)2 NH-; R5代表氢原子或(a),(b),(c),(d),(e),(f),(g),(h),(i),(j),(k) 或(l); R6表示氢原子,卤素原子,硝基或氰基; 或其药学上可接受的盐。 本发明还涉及具有作为活性成分的所述化合物或其药学上可接受的盐的具有功能性不应期的延长作用的抗心律失常药。
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公开(公告)号:US06677371B1
公开(公告)日:2004-01-13
申请号:US10069002
申请日:2002-03-29
申请人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号: A61K3135
CPC分类号: C07D311/22
摘要: This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, an aryl group or a heteroaryl group; R5 represents a hydrogen atom or a C1-6 alkyl group; X is absent or represents C═O or SO2; R6 represents a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group; R7 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译: 本发明涉及式(I)的4-氧代苯并吡喃衍生物,其中R 1和R 2各自独立地表示氢原子,C 1-6烷基或苯基; R 3表示羟基或C 1-6烷基羰基氧基; R 4表示氢原子,C 3-6环烷基,C 1-6烷基,C 1-6烷基羰基,C 1-6烷基氨基羰基,二-C 1-6烷基氨基羰基,芳基或 杂芳基; R 5表示氢原子或C 1-6烷基; X不存在或表示C = O或SO 2; R 6表示氢原子,C 1-6烷基或C 3-6环烷基; R 7表示氢原子,卤素原子,硝基或氰基; 或其药学上可接受的盐。 本发明还涉及一种用于治疗对包含所述化合物或其药学上可接受的盐作为活性成分的具有对功能不应期的延长作用的心律的药物。
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公开(公告)号:US06589983B1
公开(公告)日:2003-07-08
申请号:US10048026
申请日:2002-03-29
申请人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人: Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号: A61K335
CPC分类号: C07D405/12 , C07D311/68 , C07D311/70
摘要: This invention relates a benzopyran denvative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a (substituted)C1-6 alkyl group or a (substituted)phenyl group,R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents a hydrogen atom, or R3 and R4 together form a bond, m represents an integer of 0-4, n represents an integer of 0-4, Y is absent, or represents CR11R12 in which R11 and R12 represent each independently a hydrogen atom or a C1-6 alkyl group, R5 represents an aryl group or a (substituted)heteroaryl group,R6 represents a hydrogen atom or a C1-6 alkyl group,R7 represents a hydrogen atom or a C1-6 alkyl group,X is absent, or represents C=O or SO2, R8 represents a hydrogen atom, a (substituted)C1-6 alkyl group or C3-6 cycloalkyl group, and R9 represents a nitro group, etc., or a pharmaceutically acceptable salt thereof. And this invention also relates an antiarrhythmic agent having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译: 本发明涉及式(I)的苯并吡喃类抗坏血酸,其中R1和R2各自独立地表示氢原子,(取代的)C1-6烷基或(取代的)苯基,R3表示羟基或C1-6烷基羰氧基 基团,R4表示氢原子,或R3和R4一起形成键,m表示0-4的整数,n表示0-4的整数,Y不存在,或表示其中R 11和R 12各自独立地表示的CR 11 R 12 氢原子或C1-6烷基,R5表示芳基或(取代)杂芳基,R6表示氢原子或C1-6烷基,R7表示氢原子或C1-6烷基, X不存在,或表示C = O或SO 2,R 8表示氢原子,(取代的)C 1-6烷基或C 3-6环烷基,R 9表示硝基等,或其药学上可接受的盐 。 本发明还涉及具有作为活性成分的所述化合物或其药学上可接受的盐具有对功能不应期的延长作用的抗心律失常药。
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公开(公告)号:US06486178B1
公开(公告)日:2002-11-26
申请号:US09701281
申请日:2000-11-28
申请人: Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Yamashita
发明人: Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Yamashita
IPC分类号: A61K314418
CPC分类号: C07D207/335 , C07C233/44 , C07C233/55 , C07C235/34 , C07C235/38 , C07C235/78 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C261/04 , C07C275/40 , C07C275/42 , C07C2601/02 , C07C2602/08 , C07D207/337 , C07D209/14 , C07D209/18 , C07D213/38 , C07D213/40 , C07D213/56 , C07D239/26 , C07D295/135 , C07D303/36 , C07D303/38 , C07D303/40 , C07D303/46 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24
摘要: The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R1 represents hydrogen atom, nitro group, cyano group, C1-6 alkylcarbonylamino, R2 and R3 each independently represent C1-6 alkyl group, R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group or represents a bond or oxygen atom together with R5, R5 represents hydrogen atom or represents a bond or oxygen atom together with R4, R6 represents hydrogen atom, hydroxyl group or NR7R8, n means 0 or an integer of 1 to 4, X represents C═O, CH2, SO2 or NR16, Y represents NR17 when X is C═O, CH2 or SO2 and represents C═O when X is NR16, Z is absent when Y represents NR17 or represents NR18 when Y is C═O, W represents aromatic groups or lactam rings, or pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供了治疗心功能不全的药物,其含有作为活性成分的式(I)的二氢化茚衍生物,其中R 1表示氢原子,硝基,氰基,C 1-6烷基羰基氨基,R 2和R 3各自独立地表示C 1-6烷基 R 4表示羟基或C 1-6烷基羰基氧基,或表示键或氧原子连同R 5,R 5表示氢原子,或表示键或氧原子与R 4,R 6表示氢原子,羟基或NR 7 R 8,n表示0 或1〜4的整数,X表示C = O,CH2,SO2或NR16,当X为C = O,CH2或SO2时,Y表示NR17,当X为NR16时,表示C = O,当Y表示NR17时Z不存在 或当Y为C = O时表示NR18,W表示芳族基团或内酰胺环,或其药学上可接受的盐。
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公开(公告)号:US6066631A
公开(公告)日:2000-05-23
申请号:US232645
申请日:1999-01-19
IPC分类号: C07D311/68 , C07D311/70 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/18 , A61K31/352 , C07D251/00 , C07D405/00 , C07D401/00
CPC分类号: C07D405/04 , C07D311/70 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/1856
摘要: The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R.sup.1 represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-6 alkoxymethyl group, etc., R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, etc., R.sup.5 represents a hydroxyl group or a C.sub.1-6 alkylcarbonyloxyl group or forms a bond together with R.sup.5, R.sup.6 represents a hydrogen atom or forms a bond together with R.sup.5, R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-6 cycloalkyl group, a phenyl group, etc. n is 0 or an integer of 1, 2, 3 or 4, W represents a phenyl group, etc., X represents C.dbd.O, CH.sub.2, SO.sub.2, etc., Y represents NR.sup.17 (in which R.sup.17 represents a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group, etc.), etc., Z does not exist or represents CH.sub.2 or NR.sup.18 (R.sup.18 represents a hydrogen atom, a C.sub.1-4 alkyl group, or a phenyl group, etc.)] or their salts.
摘要翻译: 本发明涉及式(I)的苯并二氢吡喃衍生物:其中R1表示氢原子,卤素原子,C1-6烷基,C1-6烷氧基,C3-6烷氧基甲基等, R 3和R 4各自独立地表示氢原子,C 1-6烷基等,R 5表示羟基或C 1-6烷基羰氧基,或与R 5一起形成键,R 6表示氢原子或者一起形成键 R5,R7和R8各自独立地表示氢原子,C1-6烷基,C3-6环烷基,苯基等,n为0或1,2,3或4的整数,W表示 苯基等,X表示C = O,CH 2,SO 2等,Y表示NR 17(其中R 17表示氢原子,C 1-4烷基,苯基等)等, Z不存在或表示CH2或NR18(R18表示氢原子,C1-4烷基或苯基等)]或其盐。
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公开(公告)号:US5318968A
公开(公告)日:1994-06-07
申请号:US994413
申请日:1992-12-21
申请人: Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
发明人: Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
IPC分类号: A61K31/50 , A61K31/501 , A61P7/02 , C07D237/22 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号: C07D401/12 , C07D237/22 , C07D405/12
摘要: A compound of the formula, ##STR1## or its pharmaceutically acceptable salt, and its preparation process and pharmaceutical compositions characterized by containing these compounds as effective ingredients.These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic affections, congestive heart failure, hypertension, asthma, immediate type allergy diseases and the like.
摘要翻译: 式(Ⅰ)化合物或其药学上可接受的盐,其制备方法和药物组合物的特征在于含有这些化合物作为有效成分。 这些化合物具有强的抗血栓形成活性,强心剂活性,血管扩张剂活性和抗SRS-A活性,可用作各种血栓形成,充血性心力衰竭,高血压,哮喘,立即型过敏性疾病等的预防或治疗剂。
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公开(公告)号:US5011839A
公开(公告)日:1991-04-30
申请号:US444953
申请日:1989-12-04
申请人: Keizo Tanikawa , Ryozo Saloda , Sakuya Tanaka , Kenichi Shikada
发明人: Keizo Tanikawa , Ryozo Saloda , Sakuya Tanaka , Kenichi Shikada
IPC分类号: A61K31/50 , A61P9/08 , A61P9/10 , A61P11/00 , A61P27/16 , A61P29/00 , A61P37/08 , C07D237/22 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号: C07D401/12 , C07D237/22 , C07D405/12 , C07D409/12
摘要: A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen, 2-propenyl, or straight chained or branched C.sub.1 -C.sub.4 alkyl; each of R.sub.2 and R.sub.3 which may be the same or different, is hydrogen, or straight chained or branched C.sub.1 -C.sub.3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or --AR.sub.4 wherein A is oxygen, or sulfur, and R.sub.4 is hydroen, straight chained, branched or cyclic C.sub.1 -C.sub.8 alkyl, ##STR2## wherein R.sub.5 is hydrogen, or straight chained or branched C.sub.1 -C.sub.4 alkyl; and Ar is ##STR3## wherein each Z.sub.1 and Z.sub.2 which may be the same or different, is hydrogen, halogen, straight or branched C.sub.1 -C.sub.4 alkyl, or --OR.sub.6 wherein R.sub.6 is straight or branched C.sub.1 -C.sub.4 alkyl, and B is oxygen, sulfur, or --N.dbd.C-- (to form a quinoline or pyridine ring); or a pharamaceutically acceptable salt thereof.
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公开(公告)号:US5968967A
公开(公告)日:1999-10-19
申请号:US51085
申请日:1998-04-13
IPC分类号: A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06
CPC分类号: C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04
摘要: A pyrazolone derivative represented by general formula (I) or a salt thereof: ##STR1## [wherein one of X.sup.1 and X.sup.2 is ##STR2## (wherein A is a cyano group, a cyano C.sub.1-4 alkyl group, an amino group, an amino C.sub.1-4 alkyl group, an amidino group or a guanidino group, R.sup.1 and R.sup.2 are independently hydrogen atoms, halogen atoms, C.sub.1-6 alkyl groups or the like) or the like],the other of X.sup.1 and X.sup.2 is a C.sub.1-6 alkyl group, a C.sub.3-6 alkenyl group, an aryl C.sub.1-4 alkyl group or an aryl group,one of Y.sup.1 and Y.sup.2 is ##STR3## (wherein Q is an oxygen atom or a sulfur atom, Z.sup.1 is an oxygen atom, a --NR.sup.7 -- group or a --CHR.sup.7 -- group, Z.sup.2 is a cyclic C.sub.3-7 alkylene group, a C.sub.1-3 alkylene group, a --CH.sub.2 CO-- group or --CH.sub.2 CH.sub.2 CO-- group, Z.sup.3 is an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group or the like, Z.sup.4 is a C.sub.1-3 alkylene group, and Z.sup.5 is a carboxyl group or the like, andthe other of Y.sup.1 and Y.sup.2 is a D-E- group [wherein E is a bond, a C.sub.1-4 alkylene group or a phenylene group, and D is a hydrogen atom, a C.sub.1-6 alkyl group or the like which has an inhibitory action on platelet aggregation and is useful as a preventive or therapeutic agent for various thrombotic diseases.
摘要翻译: PCT No.PCT / JP96 / 02944 Sec。 371日期:1998年4月13日 102(e)1998年4月13日PCT PCT 1996年10月11日PCT公布。 第WO97 / 13757号公报 日本1997年4月17日由通式(I)表示的吡唑啉酮衍生物或其盐:其中X1和X2之一为(其中A为氰基,氰基C1-4烷基,氨基,氨基 C 1-4烷基,脒基或胍基,R 1和R 2独立地为氢原子,卤素原子,C 1-6烷基等),X 1和X 2中的另一个为C 1-6 烷基,C 3-6烯基,芳基C 1-4烷基或芳基,Y1和Y2之一为(其中Q为氧原子或硫原子,Z1为氧原子,-NR7- 基团或-CHR7-基团,Z2为环状C3-7亚烷基,C1-3亚烷基,-CH2CO-基或-CH2CH2CO-基,Z3为氧原子,硫原子,亚磺酰基, 磺酰基等,Z4为C1-3亚烷基,Z5为羧基等,Y1和Y2中的另一个为DE-基[其中E为键,C1-4亚烷基 基团或亚苯基,D为氢原子,C1-6烷基 对血小板聚集具有抑制作用,可用作各种血栓性疾病的预防或治疗剂。
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公开(公告)号:US5750523A
公开(公告)日:1998-05-12
申请号:US676227
申请日:1996-07-23
IPC分类号: C07D237/22 , C07D401/12 , A61K31/50
CPC分类号: C07D401/12 , C07D237/22
摘要: Pyridazinone derivatives represented by the formula (I) and antiplatelet agents containing them: ##STR1## �wherein R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, X is a hydrogen atom, a chlorine atom or a bromine atom, Ar is a pyridyl group or a phenyl group substituted with OR.sup.1 (wherein R.sup.1 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group) and A {wherein A is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or OR.sup.2 (wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group)}, is C.sub.1 -C.sub.8 alkylene wherein one carbon atom on the straight chain is substituted with one OR.sup.1 group (wherein R.sup.1 is the same as defined above), and Z.sup.1 and Z.sup.2 are independently a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or a OR.sup.1 group (wherein R.sup.1 is the same as defined above)!. These compounds have strong antiplatelet effects, are excellently safe, and can be used as active ingredients of prophylactic and therapeutic drugs for various thrombotic diseases.
摘要翻译: PCT No.PCT / JP95 / 00069 Sec。 371日期:1996年7月23日 102(e)日期1996年7月23日PCT提交1995年1月24日PCT公布。 WO95 / 19969 PCT公开 日期:1997年7月27日由式(I)表示的哒嗪酮衍生物和含有它们的抗血小板剂:其中R是氢原子或C1-C4烷基,X是氢原子,氯原子 或溴原子,Ar是吡啶基或被OR 1取代的苯基(其中R1是氢原子或C1-C4烷基)和A {其中A是氢原子,卤原子,C1-C4 烷基或OR 2(其中R 2是氢原子或C 1 -C 4烷基)}是其中一个碳原子被一个OR 1基团取代的C 1 -C 8亚烷基(其中R 1与上述定义相同) ,Z 1和Z 2独立地为氢原子,卤素原子,C 1 -C 4烷基或OR 1基(其中R 1与上述定义相同)]。 这些化合物具有很强的抗血小板作用,非常安全,可用作各种血栓性疾病的预防和治疗药物的活性成分。
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公开(公告)号:US5202323A
公开(公告)日:1993-04-13
申请号:US768182
申请日:1991-10-16
申请人: Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
发明人: Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
IPC分类号: A61K31/50 , A61K31/501 , A61P7/02 , C07D237/22 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号: C07D401/12 , C07D237/22 , C07D405/12
摘要: A compound of the formula, ##STR1## or its pharmaceutically acceptable salt, and its preparation process and pharmaceutical compositions characterized by containing these compounds as effective ingredients.These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic affections, congestive heart failure, hypertension, asthma, immediate type allergy diseases and the like.
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