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公开(公告)号：US08487004B2
公开(公告)日：2013-07-16
申请号：US13524590
申请日：2012-06-15
申请人： Ruihong Chen , Allan E. Rubenstein , Xiaodong Shen , Scott Stewart , Jin-Chen Yu
发明人： Ruihong Chen , Allan E. Rubenstein , Xiaodong Shen , Scott Stewart , Jin-Chen Yu
CPC分类号： A61K9/0019 , A61K9/0014 , A61K31/165 , A61K31/167 , A61K31/19 , A61K31/196 , A61K31/282 , A61K31/366 , A61K31/395 , A61K31/4184 , A61K31/4745 , A61K31/513 , A61K31/65 , A61K31/661 , A61K31/675 , A61K31/7064
摘要： A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method comprises locally applying a composition to a neurofibroma either topically or intralesionally. This method does not encompass systemic administration of the composition to the subject to have an effect on the neurofibromas. Compositions useful for such treatments and methods of preparing the compositions are disclosed.
摘要翻译： 一种治疗神经纤维瘤的方法，例如 公开了在需要这种治疗的受试者中的真皮神经纤维瘤，皮下神经纤维瘤或浅表丛状神经纤维瘤。 该方法包括局部地将组合物局部施用于神经纤维瘤，或者局部或间质地。 该方法不包括对受试者的组合物的系统给药以对神经纤维瘤具有影响。 公开了可用于这种处理的组合物和制备组合物的方法。
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公开(公告)号：US5840848A
公开(公告)日：1998-11-24
申请号：US778467
申请日：1997-01-03
摘要： An method is disclosed for removing Type I collagen-containing tissue adjoining Type II collagen-containing animal tissue comprising treatment of unprocessed Type II collagen-containing tissue in an acidic solution in the presence of an acid proteinase and subjecting the mixture to moderate agitation for a period of time sufficient to cause digestion or separation of the Type I collagen-containing tissue from the Type II collagen-containing tissue. Also disclosed are methods for removing proteoglycans from Type II collagen-containing tissue.
摘要翻译： 公开了一种用于去除含有II型胶原的动物组织的含I型胶原的组织的方法，包括在酸性蛋白酶存在下在酸性溶液中处理未加工的含II型胶原蛋白的组织，并对该混合物进行适度搅拌 足以引起含有I型胶原的组织从含有I型胶原的组织消化或分离的时间。 还公开了从含II型胶原的组织中去除蛋白聚糖的方法。
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