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公开(公告)号：US06277383B1
公开(公告)日：2001-08-21
申请号：US08410614
申请日：1995-03-24
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
IPC分类号： A61K3936
CPC分类号： C12N15/8289 , A61K38/00 , A61K39/00 , C07K14/415 , C07K16/16 , C07K2319/02 , G01N33/569 , G01N33/56961 , G01N33/56972 , G01N33/689 , G01N33/6893 , G01N2800/24
摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
摘要翻译： 本发明提供编码两种黑麦草花粉变应原Lol p Ib家族成员，纯化的Lol p Ib.1和Lol p Ib.2蛋白及其片段的核酸序列，生产重组Lol p Ib.1或Lol p Ib的方法。 2或其至少一个片段或其衍生物或同源物，以及使用本发明的核酸序列，蛋白质和肽的方法。
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公开(公告)号：US06265566B1
公开(公告)日：2001-07-24
申请号：US08174739
申请日：1993-12-29
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
IPC分类号： C07H2104
CPC分类号： C07K16/16 , C07K14/415 , G01N2800/24
摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified LoI pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
摘要翻译： 本发明提供编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的LoI pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一个片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。
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公开(公告)号：US06180368B2
公开(公告)日：2001-01-30
申请号：US08413974
申请日：1995-03-31
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
IPC分类号： C12N1509
CPC分类号： C07K16/16 , C07K14/415 , C12N15/8289 , G01N33/569 , G01N33/56961 , G01N33/6893 , G01N2800/24
摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
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公开(公告)号：US06239269B1
公开(公告)日：2001-05-29
申请号：US08433288
申请日：1995-05-03
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
IPC分类号： A61K3936
CPC分类号： C07K16/16 , C07K14/415 , G01N2800/24
摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
摘要翻译： 本发明提供了编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的Lol pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一种片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。
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公开(公告)号：US5840316A
公开(公告)日：1998-11-24
申请号：US195947
申请日：1994-02-14
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
IPC分类号： A61K38/00 , A61K39/00 , A61P37/08 , C07K14/415 , C07K16/16 , C12N15/82 , G01N33/569 , G01N33/68 , A61K39/36
CPC分类号： C12N15/8289 , C07K14/415 , C07K16/16 , G01N33/569 , G01N33/56961 , G01N33/56972 , G01N33/689 , G01N33/6893 , A61K38/00 , A61K39/00 , C07K2319/02 , G01N2800/24
摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
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公开(公告)号：US5869333A
公开(公告)日：1999-02-09
申请号：US433885
申请日：1995-05-02
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough , Cenk Suphioglu , Eng Kok Ong
IPC分类号： A61K38/00 , A61K39/00 , A61P37/08 , C07K14/415 , C07K16/16 , C12N15/82 , G01N33/569 , G01N33/68 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C12N15/8289 , C07K14/415 , C07K16/16 , G01N33/569 , G01N33/56961 , G01N33/56972 , G01N33/689 , G01N33/6893 , A61K38/00 , A61K39/00 , C07K2319/02 , G01N2800/24
摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
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公开(公告)号：US5736149A
公开(公告)日：1998-04-07
申请号：US470165
申请日：1995-06-06
IPC分类号： A61K38/22 , A61K31/335 , A61K31/40 , A61K31/505 , A61K31/535 , A61K38/00 , A61K39/00 , A61K39/36 , A61P27/02 , A61P27/12 , A61P37/08 , C07H21/04 , C07K14/415 , C12N1/21 , C12N15/09 , C12N15/29 , C12P21/02 , C12R1/19 , A61K3/00 , A61K35/78 , A61K35/80 , C07K1/00
CPC分类号： C07K14/415 , A61K39/00 , C07K2319/00
摘要： The present invention provides a nucleic acid having a nucleotide sequence coding for Sor h I, a major allergen of Sorghum halepense, and fragments thereof. The present invention also provides purified Sor h I or at least one fragment thereof, produced in a host cell transformed with a nucleic acid sequence coding for Sor h I, or at least one fragment thereof and fragments of Sor h prepared synthetically. Sor h I and fragments thereof are useful for diagnosing, treating, and preventing allergy to Johnson grass pollen.
摘要翻译： 本发明提供了具有编码Sorh I，高粱主要变应原的Sorh I及其片段的核苷酸序列的核酸。 本发明还提供了在用编码Sorh I的核酸序列或其至少一个片段转化的宿主细胞中产生的纯化的Sorh I或其至少一个片段和合成制备的Sor h片段。 Sor h I及其片段可用于诊断，治疗和预防对Johnson草花粉的过敏。
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8.发明授权
公开(公告)号：US5691167A
公开(公告)日：1997-11-25
申请号：US175096
申请日：1993-12-29
IPC分类号： A61K38/22 , A61K31/335 , A61K31/40 , A61K31/505 , A61K31/535 , A61K38/00 , A61K39/00 , A61K39/36 , A61P27/02 , A61P27/12 , A61P37/08 , C07H21/04 , C07K14/415 , C12N1/21 , C12N15/09 , C12N15/29 , C12P21/02 , C12R1/19 , C12N15/63
CPC分类号： C07K14/415 , A61K39/00 , C07K2319/00
摘要： The present invention provides a nucleic acid having a nucleotide sequence coding for Sor h I, a major allergen of Sorghum halepense, and fragments thereof. The present invention also provides purified Sor h I or at least one fragment thereof, produced in a host cell transformed with a nucleic acid sequence coding for Sor h I, or at least one fragment thereof and fragments of Sor h prepared synthetically. Sor h I and fragments thereof are useful for diagnosing, treating, and preventing allergy to Johnson grass pollen.
摘要翻译： 本发明提供了具有编码Sorh I，高粱主要变应原的Sorh I及其片段的核苷酸序列的核酸。 本发明还提供了在用编码Sorh I的核酸序列或其至少一个片段转化的宿主细胞中产生的纯化的Sorh I或其至少一个片段和合成制备的Sor h片段。 Sor h I及其片段可用于诊断，治疗和预防对Johnson草花粉的过敏。
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公开(公告)号：US06451324B1
公开(公告)日：2002-09-17
申请号：US08434256
申请日：1995-05-03
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
IPC分类号： A61K3935
CPC分类号： C07K16/16 , C07K14/415 , C12N15/8289 , G01N33/569 , G01N33/56961 , G01N33/6893 , G01N2800/24
摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
摘要翻译： 本发明提供了编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的Lol pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一种片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。
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公开(公告)号：US06197313B1
公开(公告)日：2001-03-06
申请号：US08434418
申请日：1995-05-03
申请人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
发明人： Mohan Bir Singh , Robert Bruce Knox , Penelope Smith , Asil Avjioglu , Piyada Theerakulpisut , Terryn Hough
IPC分类号： A61K3935
CPC分类号： C07K16/16 , C07K14/415 , C12N15/8289 , G01N33/569 , G01N33/56961 , G01N33/6893 , G01N2800/24
摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.
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