公开(公告)号：US5869333A

公开(公告)日：1999-02-09

申请号：US433885

申请日：1995-05-02

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K14/415 ,  C07K16/16 ,  C12N15/82 ,  G01N33/569 ,  G01N33/68 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63

CPC分类号： C12N15/8289 ,  C07K14/415 ,  C07K16/16 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/56972 ,  G01N33/689 ,  G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/02 ,  G01N2800/24

摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

公开(公告)号：US06277383B1

公开(公告)日：2001-08-21

申请号：US08410614

申请日：1995-03-24

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

IPC分类号： A61K3936

CPC分类号： C12N15/8289 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415 ,  C07K16/16 ,  C07K2319/02 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/56972 ,  G01N33/689 ,  G01N33/6893 ,  G01N2800/24

摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

摘要翻译： 本发明提供编码两种黑麦草花粉变应原Lol p Ib家族成员，纯化的Lol p Ib.1和Lol p Ib.2蛋白及其片段的核酸序列，生产重组Lol p Ib.1或Lol p Ib的方法。 2或其至少一个片段或其衍生物或同源物，以及使用本发明的核酸序列，蛋白质和肽的方法。

公开(公告)号：US06265566B1

公开(公告)日：2001-07-24

申请号：US08174739

申请日：1993-12-29

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

IPC分类号： C07H2104

CPC分类号： C07K16/16 ,  C07K14/415 ,  G01N2800/24

摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified LoI pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

摘要翻译： 本发明提供编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的LoI pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一个片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。

公开(公告)号：US06180368B2

公开(公告)日：2001-01-30

申请号：US08413974

申请日：1995-03-31

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

IPC分类号： C12N1509

CPC分类号： C07K16/16 ,  C07K14/415 ,  C12N15/8289 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/6893 ,  G01N2800/24

摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

公开(公告)号：US06239269B1

公开(公告)日：2001-05-29

申请号：US08433288

申请日：1995-05-03

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

IPC分类号： A61K3936

CPC分类号： C07K16/16 ,  C07K14/415 ,  G01N2800/24

摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

摘要翻译： 本发明提供了编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的Lol pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一种片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。

公开(公告)号：US5840316A

公开(公告)日：1998-11-24

申请号：US195947

申请日：1994-02-14

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K14/415 ,  C07K16/16 ,  C12N15/82 ,  G01N33/569 ,  G01N33/68 ,  A61K39/36

CPC分类号： C12N15/8289 ,  C07K14/415 ,  C07K16/16 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/56972 ,  G01N33/689 ,  G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/02 ,  G01N2800/24

摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

公开(公告)号：US06451324B1

公开(公告)日：2002-09-17

申请号：US08434256

申请日：1995-05-03

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

IPC分类号： A61K3935

CPC分类号： C07K16/16 ,  C07K14/415 ,  C12N15/8289 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/6893 ,  G01N2800/24

摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

摘要翻译： 本发明提供了编码黑麦草花粉过敏原Lol pIa和Lol pIb，纯化的Lol pIa和Lol pIb蛋白及其片段的核酸序列，产生重组Lol pIa和Lol pIb的方法或其至少一种片段或衍生物或同系物 以及使用本发明的核酸序列，蛋白质和肽的方法。

公开(公告)号：US06197313B1

公开(公告)日：2001-03-06

申请号：US08434418

申请日：1995-05-03

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough

IPC分类号： A61K3935

CPC分类号： C07K16/16 ,  C07K14/415 ,  C12N15/8289 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/6893 ,  G01N2800/24

摘要： The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

公开(公告)号：US5965455A

公开(公告)日：1999-10-12

申请号：US433908

申请日：1995-05-02

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K14/415 ,  C07K16/16 ,  C12N15/82 ,  G01N33/569 ,  G01N33/68 ,  G01N33/564

CPC分类号： C12N15/8289 ,  C07K14/415 ,  C07K16/16 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/56972 ,  G01N33/689 ,  G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/02 ,  G01N2800/24

摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

摘要翻译： 本发明提供编码两种黑麦草花粉变应原Lol p Ib家族成员，纯化的Lol p Ib.1和Lol p Ib.2蛋白及其片段的核酸序列，生产重组Lol p Ib.1或Lol p Ib的方法。 2或其至少一个片段或其衍生物或同源物，以及使用本发明的核酸序列，蛋白质和肽的方法。

公开(公告)号：US5736362A

公开(公告)日：1998-04-07

申请号：US174745

申请日：1993-12-29

申请人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

发明人： Mohan Bir Singh ,  Robert Bruce Knox ,  Penelope Smith ,  Asil Avjioglu ,  Piyada Theerakulpisut ,  Terryn Hough ,  Cenk Suphioglu ,  Eng Kok Ong

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K14/415 ,  C07K16/16 ,  C12N15/82 ,  G01N33/569 ,  G01N33/68 ,  A61K39/36

CPC分类号： C12N15/8289 ,  C07K14/415 ,  C07K16/16 ,  G01N33/569 ,  G01N33/56961 ,  G01N33/56972 ,  G01N33/689 ,  G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/02 ,  G01N2800/24

摘要： The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.