公开(公告)号：US06217912B1

公开(公告)日：2001-04-17

申请号：US09352473

申请日：1999-07-13

Applicant: Jong Sang Park ,  Young Hun Choi ,  Sung Wan Kim

Inventor： Jong Sang Park ,  Young Hun Choi ,  Sung Wan Kim

IPC: A61K4714

CPC classification number: C12N15/87 ,  A61K9/1647 ,  A61K47/62 ,  A61K48/00 ,  C08G63/664 ,  C08G63/6852

Abstract: Poly[&agr;-(4-aminobutyl)-L-glycolic acid] (PAGA) is disclosed as a biodegradable composition suitable for delivering a gene into a cell. Methods of making and using PAGA are also disclosed.

Abstract translation: 公开了聚[α-（4-氨基丁基）-L-乙醇酸]（PAGA）作为适于将基因输送到细胞中的可生物降解的组合物。 还公开了制造和使用PAGA的方法。

公开(公告)号：US06303660B1

公开(公告)日：2001-10-16

申请号：US09424256

申请日：2000-02-01

Applicant: Kristofer Rubin ,  Mats Sjoquist ,  Rolf Reed

Inventor： Kristofer Rubin ,  Mats Sjoquist ,  Rolf Reed

IPC: A61K4714

CPC classification number: A61K45/06

Abstract: Primer compositions for anti-cancer agent delivery to solid tumors in mammals, including man, are disclosed. The primer comprise a pharmaceutically acceptable agent which increases the intracellular levels of cyclic adenosine monophosphate (cAMP) in the normal connective tissue cells within solid tumors. Such an agent may be selected from any agents which increase the intracellular levels of cAMP, e.g. agents binding to and stimulating receptors at the connective tissue cell surface within tumors, and agents inhibiting cAMP phosphodiesterase. Local administration of the primer to the solid tumor area results in a lowering of the interstitial pressure. Further, an agent delivery system and a method for delivery of anti-cancer agents to solid tumors are described.

Abstract translation: 公开了用于将抗癌剂递送至包括人在内的哺乳动物中的实体瘤的底物组合物。 引物包含增加在实体瘤内的正常结缔组织细胞中的环磷酸腺苷（cAMP）的细胞内水平的药学上可接受的试剂。 这样的试剂可以选自增加cAMP的细胞内水平的任何试剂，例如 与肿瘤内结缔组织细胞表面结合并刺激受体的药剂，以及抑制cAMP磷酸二酯酶的药剂。 将引物局部施用于实体瘤区导致间隙压降低。 此外，描述了将药物递送系统和将抗癌剂递送至实体瘤的方法。