公开(公告)号：US08692009B2

公开(公告)日：2014-04-08

申请号：US13386620

申请日：2010-07-29

Applicant: Yong Ho Lee ,  Manseong Jeon ,  Ki-Soo Lee ,  Heon-Yong Kwon ,  Min-Seok Cho ,  Jong-Sang Park ,  Joon Hee Cho ,  Hyeon-Gook Kim ,  Eunkyoung Song ,  Seon-Kyoung Kim ,  Dae-Sik Hong

Inventor： Yong Ho Lee ,  Manseong Jeon ,  Ki-Soo Lee ,  Heon-Yong Kwon ,  Min-Seok Cho ,  Jong-Sang Park ,  Joon Hee Cho ,  Hyeon-Gook Kim ,  Eunkyoung Song ,  Seon-Kyoung Kim ,  Dae-Sik Hong

IPC: C08F4/6592 ,  C08F4/642 ,  C08F4/643

CPC classification number: C08F4/76 ,  C07F17/00 ,  C08F4/65912 ,  C08F4/65927 ,  C08F10/00 ,  C08F210/16 ,  C08F2500/08

Abstract: The present invention relates to a novel metallocene compound, a catalyst composition comprising the same, and to olefinic polymers produced using the same. The metallocene compound according to the present invention and the catalyst composition comprising the same can be used when producing olefinic polymers, have outstanding copolymerization properties, and can produce olefinic polymers of high molecular weight. In particular, when the metallocene compound according to the present invention is employed, highly heat resistant block copolymers can be produced, and olefinic polymers can be produced which have a high melting point (Tm) even if the comonomer content is increased when producing the olefinic polymer.

Abstract translation: 本发明涉及一种新的茂金属化合物，包含该金属茂化合物的催化剂组合物以及使用其制备的烯烃聚合物。 本发明的茂金属化合物和含有该金属茂化合物的催化剂组合物可以在制造烯烃类聚合物时使用，具有突出的共聚特性，能制造高分子量的烯烃聚合物。 特别是使用本发明的金属茂化合物时，即使在制造烯烃类时共聚单体含量增加，也可以制造高耐热性嵌段共聚物，可以制造具有高熔点（Tm）的烯属聚合物 聚合物。

公开(公告)号：US08399044B2

公开(公告)日：2013-03-19

申请号：US12809054

申请日：2010-01-21

Applicant: Jong-Sang Park ,  Dae-Joong Kim ,  In-Su Baek ,  Chengzhe Bai

Inventor： Jong-Sang Park ,  Dae-Joong Kim ,  In-Su Baek ,  Chengzhe Bai

IPC: A61F13/00 ,  A61F13/02 ,  A61K9/28 ,  A61K9/70 ,  A61B17/04 ,  A61B17/10 ,  A61L17/00 ,  A61M31/00 ,  B01J13/00 ,  B05D3/00 ,  B32B19/00 ,  D02G3/00

CPC classification number: A61B17/06166 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61L17/005 ,  A61L17/145 ,  A61L2300/40 ,  Y10T428/29 ,  Y10T428/2913

Abstract: A method for coating medication for a medical product is disclosed. A technique for coating gel in a viscous semisolid state is provided to facilitate coating of medication. Coating of medication on an article can be facilitated using gel, and coating of medication on an article such as an article made of silk and an article made of polypropylene can be further facilitated.

Abstract translation: 公开了一种用于医疗产品的药物涂布方法。 提供用于涂覆粘性半固体状态的凝胶的技术以便于涂覆药物。 可以使用凝胶来促进制品上的药物涂层，并且可以进一步促进在诸如由丝制品制成的制品和由聚丙烯制成的制品上涂敷药物。

公开(公告)号：US20100256315A1

公开(公告)日：2010-10-07

申请号：US12746441

申请日：2008-12-05

Applicant: Heon-Yong Kwon ,  Nicola Maggiarosa ,  Ki-Soo Lee ,  Min-Seok Cho ,  Jong-Sang Park ,  Joon-Hee Cho ,  Yong-Ho Lee ,  Byung-Ryul Lee ,  Seon-Kyoung Kim ,  Dae-Sik Hong

Inventor： Heon-Yong Kwon ,  Nicola Maggiarosa ,  Ki-Soo Lee ,  Min-Seok Cho ,  Jong-Sang Park ,  Joon-Hee Cho ,  Yong-Ho Lee ,  Byung-Ryul Lee ,  Seon-Kyoung Kim ,  Dae-Sik Hong

IPC: C08F4/52 ,  C07D257/00 ,  B01J31/14

CPC classification number: C08F10/02 ,  C07F7/003 ,  C08F110/02 ,  C08F210/16 ,  C08F4/642 ,  C08F2500/03 ,  C08F210/14 ,  C08F4/64075

Abstract: The present invention provides a non-metallocene transition metal compound that is easily produced, includes a tetrazol group having the high polymerization activity and high temperature stability in the polymerization of olefins, and a catalytic composition that includes the transition metal compound and a cocatalyst. In addition, the present invention provides a method for efficiently producing an olefin homopolymer or copolymer by using the catalytic composition.

Abstract translation: 本发明提供易于生产的非金属茂过渡金属化合物，包括在烯烃聚合中具有高聚合活性和高温稳定性的四唑基和包含过渡金属化合物和助催化剂的催化组合物。 此外，本发明提供了通过使用催化剂组合物有效地制备烯烃均聚物或共聚物的方法。

公开(公告)号：US06267987B1

公开(公告)日：2001-07-31

申请号：US09210014

申请日：1998-12-11

Applicant: Jong-Sang Park ,  Min-Hyo Seo

Inventor： Jong-Sang Park ,  Min-Hyo Seo

IPC: A61K914

CPC classification number: C08L67/04 ,  A61K9/1647 ,  A61K47/34 ,  A61K47/593 ,  C08G63/6852 ,  Y10S977/916 ,  Y10T428/2848

Abstract: A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides, proteins, peptides, and drugs is disclosed. Biologically active moieties, such as drugs, ligands, and the like, can be coupled to the free amino groups of the polymer.

Abstract translation: 公开了用于递送生物活性剂如DNA，RNA，寡核苷酸，蛋白质，肽和药物的可生物降解的带正电荷的氨基烷基聚酯聚合物。 生物活性部分，例如药物，配体等可以与聚合物的游离氨基偶联。

公开(公告)号：US20120172548A1

公开(公告)日：2012-07-05

申请号：US13337972

申请日：2011-12-27

Applicant: Joon-Hee CHO ,  Ki-Soo LEE ,  Yong-Gyu HAN ,  Dae-Sik HONG ,  Heon-Yong KWON ,  Jong-Sang PARK ,  Seon Kyoung KIM

Inventor： Joon-Hee CHO ,  Ki-Soo LEE ,  Yong-Gyu HAN ,  Dae-Sik HONG ,  Heon-Yong KWON ,  Jong-Sang PARK ,  Seon Kyoung KIM

IPC: C08F210/08 ,  B01J31/12 ,  C08F2/34 ,  C08F210/14 ,  C08F2/01

CPC classification number: C08F210/14 ,  C08F4/65904 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/6592 ,  C08F4/65925 ,  C08F4/65927 ,  C08F10/00 ,  C08F210/08 ,  C08F210/16 ,  C08L23/08 ,  C08F2500/05 ,  C08F2500/07 ,  C08F2500/10 ,  C08F2500/12

Abstract: A polyolefin has 1) a density in the range of 0.93 to 0.97 g/cm3, 2) a BOCD (Broad Orthogonal Co-monomer Distribution) index defined by a given equation in the range of 1 to 5, and 3) a molecular weight distribution (weight average molecular weight/number average molecular weight) in the range of 4 to 10. A supported hybrid metallocene catalyst comprises a first metallocene compound represented by a first given formulae, a second metallocene compound represented by one of three given formulae, and a support.

Abstract translation: 聚烯烃具有1）在0.93至0.97g / cm 3范围内的密度，2）由给定方程式定义在1至5范围内的BOCD（广义正交共聚单体分布）指数，和3）分子量 分布（重均分子量/数均分子量）在4〜10的范围内。负载的杂化金属茂催化剂包括由第一给定式表示的第一茂金属化合物，由三个给定式中的一个表示的第二茂金属化合物和 一个支持。

公开(公告)号：US07915360B2

公开(公告)日：2011-03-29

申请号：US12312823

申请日：2007-11-15

Applicant: Dae-Sik Hong ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Joon-Hee Cho ,  Seon-Kyoung Kim ,  Choong-Hoon Lee ,  Eun-Jung Lee ,  Seung-Whan Jung ,  Ki-Su Ro

Inventor： Dae-Sik Hong ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Joon-Hee Cho ,  Seon-Kyoung Kim ,  Choong-Hoon Lee ,  Eun-Jung Lee ,  Seung-Whan Jung ,  Ki-Su Ro

IPC: C08F4/6592 ,  C08F4/642 ,  B01J31/22

CPC classification number: C08F210/16 ,  C08F4/65904 ,  C08F4/65912 ,  C08F2420/02 ,  Y10S526/943 ,  C08F4/6592 ,  C08F4/65916 ,  C08F210/14 ,  C08F2500/12 ,  C08F2500/03

Abstract: The present invention provides a new supported catalyst for olefin polymerization prepared by reacting a novel transition metal compound on a cocatalyst-supported support, in which the transition metal compound is coordinated with a monocyclopentadienyl ligand to which an amido-quinoline group is introduced, a method for preparing the same, and a method for preparing a polyolefin using the same. The transition metal catalyst compound used in the present invention is configured such that an amido group is linked in a cyclic form via a phenylene bridge. Thus, a pentagon ring structure of the transition metal compound is stably maintained, so that monomers easily approach the transition metal compound and the reactivity is also high. Accordingly, if the supported catalyst for olefin polymerization prepared according to the present invention is applied to the copolymerization of ethylene and monomers having large steric hindrance in a slurry or a gas phase process, a linear, a linear, high molecular weight polyolefin having a very low density of 0.900 to 0.970 g/cc or less can be obtained.

Abstract translation: 本发明提供了一种用于烯烃聚合的新型负载催化剂，其通过使新型过渡金属化合物在助催化剂负载的载体上反应制备，其中过渡金属化合物与引入酰胺基 - 喹啉基团的单环戊二烯基配体配位， 以及制备使用该聚烯烃的聚烯烃的方法。 本发明中使用的过渡金属催化剂化合物被配置成使得酰胺基通过亚苯基桥连接成环状。 因此，稳定地维持过渡金属化合物的五角环结构，使得单体容易接近过渡金属化合物，反应性也高。 因此，如果将根据本发明制备的用于烯烃聚合的负载型催化剂用于在浆料或气相方法中乙烯与具有大的空间位阻的单体的共聚合，则具有极性的直链，直链，高分子量的聚烯烃 可以得到0.900〜0.970g / cc以下的低密度。

公开(公告)号：US20100093959A1

公开(公告)日：2010-04-15

申请号：US12312823

申请日：2007-11-15

Applicant: Dae-Sik Hong ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Joon-Hee Cho ,  Seon-Kyoung Kim ,  Choong-Hoon Lee ,  Eun-Jung Lee ,  Seung-Whan Jung ,  Ki-Su Ro

Inventor： Dae-Sik Hong ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Joon-Hee Cho ,  Seon-Kyoung Kim ,  Choong-Hoon Lee ,  Eun-Jung Lee ,  Seung-Whan Jung ,  Ki-Su Ro

IPC: C08F4/6592 ,  B01J31/14 ,  B01J37/00

CPC classification number: C08F210/16 ,  C08F4/65904 ,  C08F4/65912 ,  C08F2420/02 ,  Y10S526/943 ,  C08F4/6592 ,  C08F4/65916 ,  C08F210/14 ,  C08F2500/12 ,  C08F2500/03

Abstract: The present invention provides a new supported catalyst for olefin polymerization prepared by reacting a novel transition metal compound on a cocatalyst-supported support, in which the transition metal compound is coordinated with a monocyclopentadienyl ligand to which an amido-quinoline group is introduced, a method for preparing the same, and a method for preparing a polyolefin using the same. The transition metal catalyst compound used in the present invention is configured such that an amido group is linked in a cyclic form via a phenylene bridge. Thus, a pentagon ring structure of the transition metal compound is stably maintained, so that monomers easily approach the transition metal compound and the reactivity is also high. Accordingly, if the supported catalyst for olefin polymerization prepared according to the present invention is applied to the copolymerization of ethylene and monomers having large steric hindrance in a slurry or a gas phase process, a linear, a linear, high molecular weight polyolefin having a very low density of 0.900 to 0.970 g/cc or less can be obtained.

Abstract translation: 本发明提供了一种用于烯烃聚合的新型负载催化剂，其通过使新型过渡金属化合物在助催化剂负载的载体上反应制备，其中过渡金属化合物与引入酰胺基 - 喹啉基团的单环戊二烯基配体配位， 以及制备使用该聚烯烃的聚烯烃的方法。 本发明中使用的过渡金属催化剂化合物被配置成使得酰胺基通过亚苯基桥连接成环状。 因此，稳定地维持过渡金属化合物的五角环结构，使得单体容易接近过渡金属化合物，反应性也高。 因此，如果将根据本发明制备的用于烯烃聚合的负载型催化剂用于在浆料或气相方法中乙烯与具有大的空间位阻的单体的共聚合，则具有极性的直链，直链，高分子量的聚烯烃 可以得到0.900〜0.970g / cc以下的低密度。

公开(公告)号：US08075940B2

公开(公告)日：2011-12-13

申请号：US12866235

申请日：2009-01-19

Applicant: Dae-Joong Kim ,  In-Su Baek ,  Jong-Sang Park ,  Hye-Yeong Nam ,  Chengzhe Bai

Inventor： Dae-Joong Kim ,  In-Su Baek ,  Jong-Sang Park ,  Hye-Yeong Nam ,  Chengzhe Bai

IPC: A61L33/00

CPC classification number: A61L27/507 ,  A61L27/16 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/416 ,  A61L2420/02 ,  A61M1/3655 ,  C08L27/18

Abstract: A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.

Abstract translation: 公开了一种用于涂覆生物活性材料和涂覆有生物活性材料的结构的方法。 生物活性物质涂布方法包括：将作为生物活性物质生产的涂布溶液溶解在具有内腔的结构内的混合溶剂中; 以及在所述结构的内表面和外表面中的至少一个上以不同的浓度涂覆所述生物活性材料。 将混合溶剂与具有不同特征的两种或更多种溶剂混合。 可以减少血管和炎症的窒息的发生。 肌成纤维细胞的大小的增加不被抑制。 将药物溶解在混合溶剂中时，制成涂布溶液，混合溶剂是作为极性溶剂制备混合溶剂，非极性溶剂以一定比例混合。

公开(公告)号：US20100121006A1

公开(公告)日：2010-05-13

申请号：US12451198

申请日：2008-05-02

Applicant: Joon-Hee Cho ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Dae-Sik Hong ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Seon-Kyoung Kim

Inventor： Joon-Hee Cho ,  Ki-Soo Lee ,  Yong-Gyu Han ,  Dae-Sik Hong ,  Heon-Yong Kwon ,  Jong-Sang Park ,  Seon-Kyoung Kim

IPC: C08F210/14 ,  C08F210/08

CPC classification number: C08F210/16 ,  C08F4/65912 ,  C08F4/6592 ,  C08F4/65925 ,  C08F10/00 ,  C08F4/65904 ,  C08F4/65916 ,  C08F210/08 ,  C08F2500/13 ,  C08F2500/07 ,  C08F2500/12 ,  C08F2500/14 ,  C08F2500/05

Abstract: The present invention relates to a polyolefin that has high environmental stress cracking resistance (ESCR), a high impact property, and an excellent die swell property, and a method of preparing the same. According to the method of preparing polyolefin of the present invention, a supported hybrid metallocene catalyst and an alpha olefin comonomer having 4 or more carbon atoms are used to obtain polyolefin having the bimodal or multimodal molecular weight distribution curves during the single reactor polymerization. The polyolefin has excellent processability, a melt flow rate ratio (MFRR) that is useful to processing, excellent shapability, impact strength, tensile strength, in particular, environmental stress cracking resistance (ESCR) and full notch creep test (FNCT), thus being used to manufacture the blow molded product.

Abstract translation: 本发明涉及具有高耐环境应力开裂性（ESCR），高冲击性和优异的模具膨胀性的聚烯烃及其制备方法。 根据本发明的制备聚烯烃的方法，使用负载的杂化茂金属催化剂和具有4个或更多个碳原子的α-烯烃共聚单体来获得在单反应器聚合期间具有双峰或多峰分子量分布曲线的聚烯烃。 聚烯烃具有优异的加工性能，对加工有用的熔体流动速率比（MFRR），优异的成形性，冲击强度，拉伸强度，特别是环境应力开裂性（ESCR）和全切口蠕变试验（FNCT），因此 用于制造吹塑产品。

公开(公告)号：US20080317814A1

公开(公告)日：2008-12-25

申请号：US12094022

申请日：2005-11-17

Applicant: Dae-Joong Kim ,  Chul-Soo Gim ,  Jai-Young Ko ,  Jong-Sang Park ,  Tae-Gun Kwon ,  Byung-Ha Lee ,  Woo-Kyung Lee ,  Hye-Yeong Nam ,  Hyun-Jung Lim

Inventor： Dae-Joong Kim ,  Chul-Soo Gim ,  Jai-Young Ko ,  Jong-Sang Park ,  Tae-Gun Kwon ,  Byung-Ha Lee ,  Woo-Kyung Lee ,  Hye-Yeong Nam ,  Hyun-Jung Lim

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2/06 ,  A61L29/16 ,  A61L2300/416

Abstract: Disclosed herein are a tube for arteriovenous anastomosis useful in hemodialysis patients and an insert for use in medicinal operation in the body. The tube or the insert are repetitively treated with a medicament on the surface thereof, which provides stable communication between an artery and a vein of a patient under hemodialysis and can greatly reduce stenosis at arteriovenous connections by releasing the medicament at a suitable rate over a prolonged period of time.

Abstract translation: 本文公开了用于血液透析患者的动静脉吻合管和用于体内药物操作的插入物。 管或插入物在其表面上用药物重复地处理，其在血液透析下提供患者的动脉和静脉之间的稳定连通，并且可以通过在延长的时间内以合适的速率释放药物来大大减少动静脉连接处的狭窄 一段的时间。