公开(公告)号：US4341719A

公开(公告)日：1982-07-27

申请号：US238327

申请日：1981-02-26

申请人： Rolf Putter ,  Theodor Pfister ,  Manfred Niese ,  Peter Wenzl

发明人： Rolf Putter ,  Theodor Pfister ,  Manfred Niese ,  Peter Wenzl

IPC分类号： C07C309/50 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/22 ,  C07C309/47 ,  C07C143/66

CPC分类号： C07C309/00

摘要： A process for the preparation of 1-amino-2-ethoxy-naphthalene-6-sulphonic acid from 2-hydroxy-naphthalene-6-sulphonic acid which comprises:A. contacting 2-hydroxy-naphthalene-6-sulphonic acid with at least an equimolar amount of an alkali metal nitrite in aqueous solution or suspension in the presence of hydrochloric acid, solution or suspension having a pH in the range of 2 to 5 and being at a temperature of 0.degree. to 20.degree. C.;B. reducing the reaction product of step A in an aqueous suspension by contacting the same with excess iron in the presence of at least an equivalent amount of iron-II ions, relative to the reaction product obtained according to step A, in the presence of a mineral acid at a temperature from 50.degree. to 120.degree. C., and treating the thus-obtained reaction mixture with aqueous alkali metal hydroxide in the presence of iron oxide;C. contacting the product of step B with excess acetic anhydride in an aqueous solution or suspension at a pH in the range of 3 to 10 at a temperature from 0.degree. to 100.degree. C.;D. contacting the product of step C with an ethylating agent in the presence of an acid binding agent in an aqueous-organic solvent or diluent in a pH range from 8 to 14 at a temperature from 20.degree. to 150.degree. C.; andE. deacetylating the product of step D by contacting the same at reflux with an aqueous alkali metal hydroxide.

摘要翻译： 一种从2-羟基 - 萘-6-磺酸制备1-氨基-2-乙氧基 - 萘-6-磺酸的方法，其包括：A.将2-羟基 - 萘-6-磺酸与至少 在盐酸，溶液或悬浮液的存在下，在pH为2至5，温度为0至20℃的水溶液或悬浮液中，等摩尔量的碱金属亚硝酸盐。 B.通过在相对于根据步骤A获得的反应产物存在下，在至少相当量的铁-II离子的存在下，使其与过量的铁接触，将步骤A的反应产物还原在水性悬浮液中 在50〜120℃的温度下进行无机酸处理，在氧化铁存在下用碱金属氢氧化物水溶液处理得到的反应混合物; C.将步骤B的产物与过量的乙酸酐在0至100℃的温度下，在3至10的pH范围内的水溶液或悬浮液中接触。 D.在酸性粘合剂存在下，在pH范围为8-14的含水有机溶剂或稀释剂中，在20-150℃的温度下，使步骤C的产物与乙基化剂接触。 和E.通过使其与碱金属氢氧化物水溶液在回流下使其脱离乙酰化步骤D的产物。

公开(公告)号：US4107202A

公开(公告)日：1978-08-15

申请号：US782211

申请日：1977-03-28

申请人： Ransom Brown Conrow ,  Seymour Bernstein

发明人： Ransom Brown Conrow ,  Seymour Bernstein

IPC分类号： C07C331/28 ,  C07C335/16 ,  C07C143/60 ,  A61K31/185 ,  C07C143/66

CPC分类号： C07C331/28 ,  C07C335/16

摘要： 4,4'-biphenylylene bis(2-thioureylene)di-naphthalenetrisulfonic acids and their salts which are useful as inhibitors of the complement system of warm-blooded animals, and the 8-isothiocyanato-1,3,6-naphthalenetrisulfonic acids and their salts which are new intermediates for the preparation of the active compounds.

摘要翻译： 4,4'-联苯亚甲基双（2-硫代亚苯基）二萘硫磺酸及其盐，可用作温血动物补体系统的抑制剂，8-异硫氰酸酯-1,3,6-萘三磺酸及其盐 作为制备活性化合物的新中间体的盐。

公开(公告)号：US4178308A

公开(公告)日：1979-12-11

申请号：US920033

申请日：1978-06-28

申请人： Willi Schossler ,  Horst Behre ,  Rolf Putter

发明人： Willi Schossler ,  Horst Behre ,  Rolf Putter

IPC分类号： C07C309/50 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32 ,  C22B34/12 ,  H03D13/00 ,  C07C143/66

CPC分类号： C22B34/12

摘要： A process has been invented for the preparation of a mono-alkali metal salt of 1-amino-8-naphthol-3,6-disulphonic acid comprising reacting 1-naphthylamine-3,6,8-trisulphonic acid and/or a salt thereof and/or a naphthylamine-trisulphonic acid isomer mixture and/or salt thereof with an alkali metal hydroxide solution at elevated pressure and elevated temperature and in the presence of an alcohol or alcoholate, and separating out the mono-alkali metal salt by acidification. The process results in the procurement of higher yields of the desired product and in the formation of less by-products.

摘要翻译： 已经发明了一种制备1-氨基-8-萘酚-3,6-二磺酸的单碱金属盐的方法，其包括使1-萘胺-3,6,8-三磺酸和/或其盐 和/或萘胺 - 三磺酸异构体混合物和/或其盐与碱金属氢氧化物溶液在升高的压力和升高的温度下，在醇或醇化物的存在下，通过酸化分离出单碱金属盐。 该过程导致采购更高产量的所需产品和形成较少的副产物。

公开(公告)号：US3646005A

公开(公告)日：1972-02-29

申请号：US3646005D

申请日：1967-03-10

申请人： UGINE KUHLMANN

发明人： ROE RENE PIERRE VICTOR ,  INFERIEURE SEINE ,  THIROT GERARD

IPC分类号： C07B45/02 ,  C07D231/56 ,  C07D249/18 ,  C07D263/56 ,  C07D263/58 ,  C07D277/68 ,  C09B43/02 ,  C07C143/60 ,  C07C143/66

CPC分类号： C09B43/02 ,  C07B45/02 ,  C07D231/56 ,  C07D249/18 ,  C07D263/56 ,  C07D263/58 ,  C07D277/68

摘要： GROUPS.

-N(-R1)-R2

WHEREIN A REPRESENTS THE RESIDUE OF A DIZAOTISABLE AROMATIC OR HETEROCYCLIC AMINE, B REPRESENTS THE RESIDUE OF A COUPLING COMPOUND, R1 REPRESENTS A HYDROGEN ATOM OR AN ALKYL OR ARYL RESIDU, R2 REPRESENTS A HYDROGEN ATOM OR AN ALKYL RESIDUE, AND X'' AND Y'' EACH REPRESENT HYDROGEN OR HALOGEN ATOMS OR HYDROXY, ALKOXY, CARBOXY, SULPHO OR

1-(B-N=N-),4-(HO3S-),(HO3S-),X'',Y''-DECALIN

1,2,3,4,4A,7,8,8A-OCTAHYDRONAPHTHALENE

1-(R1-N(-R2)-),2-(A-N=N-),3,4-DI(HO3S-),X'',Y''-

THE PRESENT INVENTION RELATES TO A PROCESS FOR THE SULPHONOATION OF AN AROMATIC OR HETEROCYCLIC POLYNUCLEAR AMINE WHICH COMPRISES TREATING THE AMINE, DISPERSED OR DISSOLVED IN AN AQUEOUS SOLUTION OF A WATER-SOLUBLE SALT OF SULPHUROUS ACID, WITH AN OXIDISING AGENT OF WHICH THE OXIDATION POTENTIAL, MEASURED AT 20*C, AND PH( WITH RESPECT TO THE NORMAL HYDROGEN ELECTRODE, IS BETWEEN +0.4 AND +0.7 VOLT, THE PH OF THE MEDUM BEING MAINTAINED APPROXIMATELY CONSTANT AT A VALUE BETWEEN 3 AND 9.5. IT ALSO RELATES TO NEW SULPHONATED POLYNUCLEAR AMINES AND TO AZO DYESTUFFS HAVING ONE OF THE FORMULAE:

公开(公告)号：US4166826A

公开(公告)日：1979-09-04

申请号：US920032

申请日：1978-06-28

申请人： Willi Schossler ,  Rolf Putter ,  Horst Behre

发明人： Willi Schossler ,  Rolf Putter ,  Horst Behre

IPC分类号： C07C309/50 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32 ,  C07C143/66

CPC分类号： C07C303/22

摘要： A process has been invented for the preparation of a mono-alkali metal of 1-amino-8-naphthol-3,6-disulphonic acid, comprising reacting 1-naphthylamine-3,6,8-trisulphonic acid and/or a salt thereof and/or a naphthylamine trisulphonic acid isomer mixture and/or salt thereof with an alkali metal hydroxide solution in the presence of an alcohol and/or alcoholate and in the presence of a substance which contains at least one oxygen atom bonded to a nitrogen atom, at elevated pressure and elevated temperature, and separating out the mono-alkali metal salt of 1-amino-8-naphthol-3,6-disulphonic acid by acidification. The process results in the procurement of higher yields of the desired product and in the formation of less by-products.

摘要翻译： 已经发明了一种制备1-氨基-8-萘酚-3,6-二磺酸的单碱金属的方法，包括1-萘胺-3,6,8-三磺酸和/或其盐 和/或萘胺三磺酸异构体混合物和/或其盐与碱金属氢氧化物溶液在醇和/或醇化物的存在下，在含有至少一个与氮原子键合的氧原子的物质存在下， 在升高的压力和升高的温度下，通过酸化分离出1-氨基-8-萘酚-3,6-二磺酸的单碱金属盐。 该过程导致采购更高产量的所需产品和形成较少的副产物。

公开(公告)号：US4096174A

公开(公告)日：1978-06-20

申请号：US812194

申请日：1977-07-01

申请人： Ransom Brown Conrow ,  Seymour Bernstein

发明人： Ransom Brown Conrow ,  Seymour Bernstein

IPC分类号： A61K31/185 ,  A61P37/04 ,  C07C67/00 ,  C07C325/00 ,  C07C331/28 ,  C07C335/20 ,  C07C143/66

CPC分类号： C07C335/20 ,  C07C331/28

摘要： Oxybis-phenylbis-thioureylene tetranaphthalenepoly-sulfonic acid salts, useful as complement inhibitors, and the process for their preparation.

摘要翻译： 用作补体抑制剂的氧化双 - 苯基 - 二硫代亚硫酸四 - 萘磺酸盐及其制备方法。

公开(公告)号：US4427601A

公开(公告)日：1984-01-24

申请号：US439474

申请日：1982-11-05

申请人： Erich Hammerschmidt ,  Horst Behre ,  Heinz U. Blank ,  Otto Lindner

发明人： Erich Hammerschmidt ,  Horst Behre ,  Heinz U. Blank ,  Otto Lindner

IPC分类号： C07B61/00 ,  B01J23/00 ,  B01J23/74 ,  B01J27/128 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C309/49 ,  C07C309/50 ,  C07C143/66

CPC分类号： C07C303/22

摘要： The process for preparing 1-amino-2-naphthol-4-sulphonic acid by acidifying 3-oxo-4-hydroxyimino-1,2,3,4-tetrahydronaphthalene-1-sulphonic acid or its alkali metal salt in the presence of hydrogen sulphite is carried out in the presence of iron ions.

摘要翻译： 通过在氢气存在下酸化3-氧代-4-羟基亚氨基-1,2,3,4-四氢萘-1-磺酸或其碱金属盐来制备1-氨基-2-萘酚-4-磺酸的方法 亚硫酸盐在铁离子存在下进行。

公开(公告)号：US4376737A

公开(公告)日：1983-03-15

申请号：US51659

申请日：1979-06-25

申请人： Hans Breitschmid

发明人： Hans Breitschmid

IPC分类号： C07C309/50 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C143/66

摘要： A process for the production of naphthylaminehydroxysulphonic acids which comprises simultaneously combining naphthylaminesulphonic acids containing at least two sulphonic acid groups, or the alkali metal salts thereof, and alkali lyes in the form of highly concentrated aqueous solutions at temperatures between 180.degree. and 240.degree. C. and allowing the resulting reaction mixture to react to completion, such that the time required for the metered addition of the components is not more than twice as long as the subsequent reaction time which is necessary under the chosen reaction conditions, while the water content of the reaction melt is between 0.5 and 20%, based on the total melt.

摘要翻译： 一种制备萘胺羟基磺酸的方法，其包括在180-240℃的温度下同时组合含有至少两个磺酸基的萘胺磺酸或其碱金属盐和高浓度水溶液形式的碱溶液。 并使得到的反应混合物反应完成，使得组分的计量加入所需的时间不超过在所选择的反应条件下所需的随后反应时间的两倍，而 基于总熔体，反应熔体为0.5-20％。

公开(公告)号：US4325889A

公开(公告)日：1982-04-20

申请号：US186884

申请日：1980-09-12

申请人： Horst Behre ,  Albert Hullen ,  Bruno Kruger ,  Guido Steffan

发明人： Horst Behre ,  Albert Hullen ,  Bruno Kruger ,  Guido Steffan

IPC分类号： C07C143/66

摘要： The invention relates to a process for the preparation of 1-amino-8-naphthol-3,6-disulphonic acid (H-acid) as the mono-alkali metal salt from napthylamine-trisulphonic acid isomer mixtures by alkaline hydrolysis under pressure. The separation of the H-acid is effected by utilizing an aqueous sulphuric acid which contains naphthalene- and/or nitronaphthalene- and/or naphthylamine- and/or naphthol- and/or aminonaphthol-mono-, -di-and/or-tri-sulphonic acids.

摘要翻译： 本发明涉及通过碱性水解在压力下从萘胺 - 三磺酸异构体混合物制备作为单碱金属盐的1-氨基-8-萘酚-3,6-二磺酸（H-酸）的方法。 H酸的分离是通过利用含有萘和/或硝基萘和/或萘胺和/或萘酚和/或氨基萘酚 - 单 - 和 - 或 - 三 - 磺酸。

公开(公告)号：US4130581A

公开(公告)日：1978-12-19

申请号：US838780

申请日：1977-10-03

申请人： Lawrence J. Ross

发明人： Lawrence J. Ross

IPC分类号： C07C309/50 ,  C07C143/66

CPC分类号： C07C309/50

摘要： Amino J Acid is reacted with alkali to produce J Acid. The use of a phenolic compound as a fluxing agent for the reaction mixture permits the use of higher temperatures to produce high yields of J Acid in shorter reaction times.

摘要翻译： 氨基酸与碱反应产生J酸。 使用酚类化合物作为反应混合物的助熔剂允许使用较高的温度以在更短的反应时间内产生高产率的J酸。