公开(公告)号：USRE40211E1

公开(公告)日：2008-04-01

申请号：US09810650

申请日：2001-03-15

Applicant: Fumiyoshi Urano ,  Masaaki Nakahata ,  Hirotoshi Fujie ,  Keiji Oono

Inventor： Fumiyoshi Urano ,  Masaaki Nakahata ,  Hirotoshi Fujie ,  Keiji Oono

IPC: C07C245/12 ,  C07C245/16

CPC classification number: G03F7/039

Abstract: wherein R1 is a C3-8 branched or cyclic alkyl group, and R2 is a C1-8 straight-chain, branched or cyclic alkyl group, is effective as a photoacid generator when used in a photoresist material for light of 300 nm or less.

Abstract translation: 其中R 1是C 3-8支链或环状烷基，R 2是C 1-8烷基， SUB>直链，支链或环状烷基，当用于300nm以下的光的光致抗蚀剂材料中时，作为光致酸产生剂是有效的。

公开(公告)号：US5817778A

公开(公告)日：1998-10-06

申请号：US970035

申请日：1997-11-13

Applicant: Thomas G. Archibald ,  Der-Shing Huang ,  Mark H. Pratton ,  James C. Barnard

Inventor： Thomas G. Archibald ,  Der-Shing Huang ,  Mark H. Pratton ,  James C. Barnard

IPC: B01J31/02 ,  C07B61/00 ,  C07C245/16

CPC classification number: C07C245/16

Abstract: Diazomethane is prepared in a batch process on a scale of at least 50 gram-moles per batch, from an N-methyl-N-nitroso amine in an organic solvent and an inorganic base in an aqueous solution by the use of a phase transfer catalyst and by controlling the choice of solvent, reagent concentrations, addition rate and reaction temperature to cause codistillation of the product and the organic solvent in such a manner that the concentration of diazomethane in both liquid and vapor phases are controlled within limits that will prevent detonation of the diazomethane.

Abstract translation: 重氮甲烷以分批方法制备，每批至少50克摩尔的量级，由有机溶剂中的N-甲基-N-亚硝基胺和水溶液中的无机碱通过使用相转移催化剂 并通过控制溶剂的选择，试剂浓度，加入速率和反应温度来引起产物和有机溶剂的共蒸馏，使液相和汽相中重氮甲烷的浓度控制在防止爆炸的范围内 重氮甲烷。

公开(公告)号：US20070249817A1

公开(公告)日：2007-10-25

申请号：US11629149

申请日：2005-06-23

Applicant: Jürgen Haase

Inventor： Jürgen Haase

IPC: C07C245/16

CPC classification number: C07C245/16

Abstract: The invention relates to a method for producing diazoalkanes, which is characterized by dissolving a diazoalkane precursor in a first solvent, dissolving a base in a second solvent, allowing the substances to react in a reactor while forming the diazoalkane and removing the diazoxaline under reduced pressure. The inventive method is especially suitable for producing diazomethane.

Abstract translation: 本发明涉及一种重氮烷烃的制造方法，其特征在于将重氮烷烃前体溶解在第一溶剂中，将碱溶解在第二溶剂中，使得物质在反应器中反应而形成重氮烷并在减压下除去二氮唑 。 本发明的方法特别适用于生产重氮甲烷。

公开(公告)号：US4035568A

公开(公告)日：1977-07-12

申请号：US637090

申请日：1975-12-03

Applicant: Carl P. Schaffner ,  Witold Mechlinski

Inventor： Carl P. Schaffner ,  Witold Mechlinski

IPC: C07C245/16 ,  C07H17/08

CPC classification number: C07H17/08 ,  C07C245/16

Abstract: Derivatives of amphoteric polyene macrolide antibiotics which carry, on the lactone ring, a carboxyl group and an amino sugar characterized by a primary amine group, consist of (a) the methyl, ethyl or propyl ester formed by esterification of the carboxyl group, and (b) salts of such polyene esters constituted as acid addition salts formed with the amine group. The derivatives (a) and (b) have effective antimicrobial activity, e.g. antifungal potency, comparable to the base antibiotics, and the acid salts (b), produced by suitable acids, e.g. hydrochlorides, can be made to have good water solubility which is normally unattainable with the base compounds and is of special advantage in a compound which retains strong activity. Other addition salts are also of value, for example to provide lipid-soluble forms of these antifungal polyenes. Esterification of these chemically sensitive antibiotics is unusually successful using diazomethane, diazoethane or diazopropane with tetrahydrofurane as solvent to produce the ester dissolved therein, avoiding degradation of the base antibiotic or of its potency.

Abstract translation: 在内酯环上携带羧基和以伯胺为特征的氨基糖的两性多烯大环内酯抗生素的衍生物由（a）通过羧基酯化形成的甲基，乙基或丙基酯和（ b）由与胺基形成的酸加成盐构成的这种多烯酯的盐。 衍生物（a）和（b）具有有效的抗微生物活性，例如 与基础抗生素相当的抗真菌效力和由合适的酸生产的酸式盐（b），例如， 可以使盐酸盐具有良好的水溶性，这通常与碱性化合物无法实现，并且在保持强烈活性的化合物中具有特别的优点。 其它加成盐也是有价值的，例如提供这些抗真菌多烯的脂溶性形式。 使用重氮甲烷，重氮乙烷或二氮丙烷与四氢呋喃作为溶剂，这些化学敏感的抗生素的酯化是非常成功的，以产生溶解在其中的酯，避免了碱性抗生素的降解或其效力。

公开(公告)号：US3945993A

公开(公告)日：1976-03-23

申请号：US152460

申请日：1971-06-07

Applicant: Carl P. Schaffner ,  Witold Mechlinski

Inventor： Carl P. Schaffner ,  Witold Mechlinski

IPC: C07C245/16 ,  C07H17/08 ,  C07H15/22

CPC classification number: C07H17/08 ,  C07C245/16

Abstract: Derivatives of amphoteric polyene macrolide antibiotics which carry, on the lactone ring, a carboxyl group and an amino sugar characterized by a primary amine group, consist of (a) the methyl, ethyl or propyl ester formed by esterification of the carboxyl group, and (b) salts of such polyene esters constituted as acid addition salts formed with the amine group. The derivatives (a) and (b) have effective antimicrobial activity, e.g. antifungal potency, comparable to the base antibiotics, and the acid salts (b), produced by suitable acids, e.g. hydrochlorides, can be made to have good water solubility which is normally unattainable with the base compounds and is of special advantage in a compound which retains strong activity. Other addition salts are also of value, for example to provide lipid-soluble forms of these antifungal polyenes. Esterification of these chemically sensitive antibiotics is unusually successful using diazomethane, diazoethane or diazopropane with tetrahydrofurane as solvent to produce the ester dissolved therein, avoiding degradation of the base antibiotic or of its potency.

Abstract translation: 在内酯环上携带羧基和以伯胺为特征的氨基糖的两性多烯大环内酯抗生素的衍生物由（a）通过羧基酯化形成的甲基，乙基或丙基酯和（ b）由与胺基形成的酸加成盐构成的这种多烯酯的盐。 衍生物（a）和（b）具有有效的抗微生物活性，例如 与基础抗生素相当的抗真菌效力和由合适的酸生产的酸式盐（b），例如， 可以使盐酸盐具有良好的水溶性，这通常与碱性化合物无法实现，并且在保持强烈活性的化合物中具有特别的优点。 其它加成盐也是有价值的，例如提供这些抗真菌多烯的脂溶性形式。 使用重氮甲烷，重氮乙烷或二氮丙烷与四氢呋喃作为溶剂，这些化学敏感的抗生素的酯化是非常成功的，以产生溶解在其中的酯，避免了碱性抗生素的降解或其效力。

公开(公告)号：US20220242818A1

公开(公告)日：2022-08-04

申请号：US17611712

申请日：2019-05-21

Applicant: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.

Inventor： Hao HONG ,  Jiangping LU ,  Enxuan ZHANG ,  Wei SHEN ,  Honglei YAN ,  Zhen ZHANG

IPC: C07C245/16

Abstract: Provided is a preparation process of diazomethane. The preparation process includes: step S1, taking N-methylurea as a raw material to continuously prepare, in a continuous reactor, a first product system containing N-methyl-N-nitrosourea; step S2, performing continuous extraction and continuous back-extraction on the first product system to obtain an N-methyl-N-nitrosourea solution; step S3, enabling the N-methyl-N-nitrosourea solution to continuously react with an alkaline solution in a continuous reactor to obtain a second product system containing the diazomethane; and step S4, performing continuously liquid separation, water freezing and removal on the second product system, to obtain the diazomethane.

公开(公告)号：US09593073B2

公开(公告)日：2017-03-14

申请号：US14373828

申请日：2013-01-23

Applicant: BAKHU LIMITED

Inventor： Lee Proctor

IPC: C07C245/16 ,  C07C241/00 ,  C07C243/04

CPC classification number: C07C241/00 ,  C07C243/04 ,  C07C245/16 ,  C07C2531/02

Abstract: The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used.

Abstract translation: 本发明涉及形成重氮烷烃的方法。 本发明的一个方面提供了从原料制备N-烷基-N-亚硝基化合物的方法，其包括使用三元酸酸化胺。 本发明的第二方面提供了一种制备重氮烷的方法，包括使N-烷基-N-亚硝基化合物与碱和相转移催化剂反应，其中不使用有机溶剂。

公开(公告)号：US09249088B2

公开(公告)日：2016-02-02

申请号：US13879889

申请日：2011-11-01

Applicant: Peter Poechlauer ,  Rafael Wilhelmus Elisabeth Ghislain Reintjens ,  Hubertus Johannes Adrianus Dielemans ,  Mehul Thathagar ,  Jeroen Hubertina Gerardus Konings

Inventor： Peter Poechlauer ,  Rafael Wilhelmus Elisabeth Ghislain Reintjens ,  Hubertus Johannes Adrianus Dielemans ,  Mehul Thathagar ,  Jeroen Hubertina Gerardus Konings

IPC: C07C245/16 ,  C07C67/00 ,  C07C245/14 ,  C07D231/06

CPC classification number: C07C245/16 ,  C07C67/00 ,  C07C245/14 ,  C07D231/06 ,  C07C69/78

Abstract: A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.

Abstract translation: 一种制备重氮化合物的反应产物的方法，该方法包括：a。 向第一反应器连续供应重氮化合物的前体; 水溶性溶剂; 基地和水; b。 混合重氮化合物的前体; 水溶性溶剂; 碱和水生成重氮化合物; C。 连续地从第一反应器中通过疏水膜除去形成的重氮化合物的第二反应器; d。 从第一反应器中连续除去未进入第二反应器的所有反应产物; e。 在非水混溶性溶剂中连续向第二反应器供给基材; F。 混合上述组分以产生重氮化合物的反应产物; 和g。 从第二反应器中连续除去非水混溶性溶剂和重氮化合物的反应产物，以及适于进行这种方法的设备。

公开(公告)号：US06962983B2

公开(公告)日：2005-11-08

申请号：US10129404

申请日：2000-12-15

Applicant: Antony John Warr ,  Lee Proctor

Inventor： Antony John Warr ,  Lee Proctor

IPC: C07C245/16

CPC classification number: C07C245/16

Abstract: A method for the production of diazomethane comprising the steps of a) feeding a base and a diazomethane precursor into a reactor vessel; b) generating gaseous diazomethane by allowing the base and the gaseous diazomethane precursor to react; and c) removing the gaseous diazomethane using a diluent gas.

Abstract translation: 一种制备重氮甲烷的方法，包括以下步骤：a）将碱和重氮甲烷前体进料到反应器容器中; b）通过使碱和气态重氮甲烷前体反应产生气态重氮甲烷; 和c）使用稀释气体除去气态重氮甲烷。

公开(公告)号：US11780803B2

公开(公告)日：2023-10-10

申请号：US16973591

申请日：2019-06-25

Applicant: Givaudan SA

Inventor： Fridtjof Schröder ,  Marcel Steck

IPC: C07C245/16 ,  B01J8/18 ,  B01J19/00 ,  C07C2/86

CPC classification number: C07C245/16 ,  B01J8/1881 ,  B01J19/0093 ,  C07C2/86 ,  B01J2208/00858 ,  B01J2219/00867 ,  B01J2219/00889 ,  C07C2523/44 ,  C07C2601/02

Abstract: A process for the continuous production of a reaction product of a diazo-compound and a substrate in a multi-stage flow reactor is disclosed.