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9 条记录 (耗时 0.016 秒)

    Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors
    2.
    发明授权
    Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors 失效
    支链烷氧基取代的2-氨基吡啶作为NOS抑制剂

    公开(公告)号：US06362195B1

    公开(公告)日：2002-03-26

    申请号：US09381887

    申请日：2000-03-28

    申请人： John Adams Lowe, III

    发明人： John Adams Lowe, III

    IPC分类号： C07D40110

    CPC分类号： C07D213/73 ,  C07D401/10

    摘要： The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula wherein R1, R2, R3 and R4 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.

    摘要翻译： 本发明涉及式I的化合物，其中R 1，R 2，R 3和R 4的6-苯基 - 吡啶-2-基胺衍生物如说明书中所定义，其表现出作为一氧化氮合酶（NOS）抑制剂的活性，含有它们的药物组合物， 用于治疗和预防中枢神经系统等疾病。

    Process for the synthesis of a photo-stabilizer
    5.
    发明授权
    Process for the synthesis of a photo-stabilizer 失效
    合成光稳定剂的方法

    公开(公告)号：US06559311B1

    公开(公告)日：2003-05-06

    申请号：US09984432

    申请日：2001-10-30

    申请人： Shroj Al Mohitkumar Desai ,  Raj Pal Singh

    发明人： Shroj Al Mohitkumar Desai ,  Raj Pal Singh

    IPC分类号： C07D40110

    CPC分类号： C07D401/12

    摘要： The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.

    摘要翻译： 本发明涉及制备通式（I）的光稳定剂的方法：其中R 1是氢，卤素，C 1 -C 12烷基，烷氧基（直链和支链），R 2是氢，C 1 -C 8烷基 ，环戊基，环己基或枯基，R3是氢，C1-C4烷基，R4是甲基或乙基，R5是C1-C8烷基，烷基苯基，烷氧基，酰基，环烷基和烯丙基，X是O，NH，C1-C8烷氧基 和烷基氨基（直链或支链）及其衍生物和中间体。

    Dimeric arylisoquinoline alkaloids and derivatives thereof
    9.
    发明授权
    Dimeric arylisoquinoline alkaloids and derivatives thereof 失效
    二聚芳基异喹啉生物碱及其衍生物

    公开(公告)号：US06331630B1

    公开(公告)日：2001-12-18

    申请号：US09527002

    申请日：2000-03-16

    申请人： Gerhard Bringmann ,  Michael R. Boyd ,  Matthias Wenzel

    发明人： Gerhard Bringmann ,  Michael R. Boyd ,  Matthias Wenzel

    IPC分类号： C07D40110

    CPC分类号： C07D491/04 ,  A61K31/47 ,  C07D217/02 ,  C07D217/04 ,  C07D217/24

    摘要： The present invention provides new naphthylisoquinoline derivatives. In particular, the present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.

    摘要翻译： 本发明提供新的萘基异喹啉衍生物。 特别地，本发明还提供由偶联的第一和第二芳基异喹啉单体组成的新的二聚芳基异喹啉生物碱。 本发明的单体和二聚体化合物具有医学上有用的性质，例如抗微生物性质，更具体地，例如抗疟疾和抗病毒性质。 本发明的单体化合物也可用作合成新型二聚芳基异喹啉生物碱的结构单元或中间体。 本发明的单体和二聚体化合物可以通过从合成或天然存在的化合物的全部合成，部分合成或衍生化，以及通过从Dioncophyllaceae和Ancistrocladaceae家族的植物中分离和纯化而以基本上纯的形式获得。