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公开(公告)号：US11576896B2
公开(公告)日：2023-02-14
申请号：US17161771
申请日：2021-01-29
申请人： AIMED BIO INC.
发明人： Dongyeol Lim , Min Cheol Kim , Amol Mhetre , Do-Hyun Nam
IPC分类号： A61K31/404 , A61K47/68 , A61P35/00 , A61K47/54 , C07D421/06
摘要： The present disclosure relates to benzoselenophene-based compounds, method of preparing the benzoselenophene-based compounds, pharmaceutical compositions and antibody-drug conjugates including the benzoselenophene-based compounds.
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公开(公告)号：US10745393B2
公开(公告)日：2020-08-18
申请号：US15301952
申请日：2015-04-03
IPC分类号： C07D417/14 , C12Q1/68 , C07D405/06 , C07D417/06 , C07D277/64 , C07D413/06 , C07D421/06 , C09B23/10 , C12Q1/6818 , C12Q1/6883 , G01N21/64 , G01N33/58 , G01N33/68
摘要： The present disclosure relates to compounds which function as small molecule fluorescent probes which aid in recognition of specific sequences in DNA and detection of Aβ aggregates. Probes/dyes of the instant disclosure are specific to AT-rich sequences of DNA and Aβ aggregates. These small organic dyes/probes are capable of exhibiting switch-on fluorescence and play an important role in fluorescence spectroscopy, diagnostics, imaging and biomedical applications.
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3.发明授权公开(公告)号：US10326083B2
公开(公告)日：2019-06-18
申请号：US15591259
申请日：2017-05-10
发明人： Tadao Yagi , Xavier Bulliard , Hyesung Choi , Rie Sakurai , Hiromasa Shibuya , Youn Hee Lim , Sung Young Yun , Gae Hwang Lee , Kwang Hee Lee , Dong-Seok Leem
IPC分类号： H01L51/00 , H01L51/44 , H01L51/42 , C07D421/04 , C07D513/04 , C07D471/04 , C07D421/14 , C07D421/06 , H01L27/30 , C07D421/00
摘要： A compound of Chemical Formula 1, and an organic photoelectric device, an image sensor, and an electronic device including the same are disclosed: In Chemical Formula 1, each substituent is the same as defined in the detailed description.
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公开(公告)号：US20190161482A1
公开(公告)日：2019-05-30
申请号：US16312024
申请日：2017-06-21
IPC分类号： C07D421/04 , C07D421/06 , C07D293/10 , A61P31/06 , A61P27/16
摘要： Compounds, compositions, and methods for the treatment of infections, inflammation, cancers, tinnitus, Meniere's disease, hearing loss, or bipolar disorder, or for providing cytoprotection against Clostridium difficile toxins, are disclosed.
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5.发明申请公开(公告)号：US20190123285A1
公开(公告)日：2019-04-25
申请号：US16165005
申请日：2018-10-19
发明人： Jisoo SHIN , Yeong Suk CHOI , Katsunori SHIBATA , Taejin CHOI , Sungyoung YUN , Ohkyu KWON , Sangmo KIM , Hiromasa SHIBUYA , Gae Hwang LEE , Yong Wan JIN , Hyesung CHOI , Chul BAIK , Hyerim HONG
IPC分类号： H01L51/00 , H01L27/30 , H01L51/42 , C07D421/04 , C07F7/08 , C07D421/14 , C07F7/30 , C07D409/06 , C07D421/06
摘要： A compound of Chemical Formula 1, and a photoelectric device, an image sensor, and an electronic device including the same are disclosed: In Chemical Formula 1, each substituent is the same as defined in the detailed description.
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公开(公告)号：US20180290991A1
公开(公告)日：2018-10-11
申请号：US16009106
申请日：2018-06-14
IPC分类号： C07D293/06 , A61K31/41 , A61K45/06 , C07D421/12 , A61K31/4439 , C07D421/04 , C07D421/06 , C07D421/14 , A61K31/501 , A61K31/4545 , A61K31/454
摘要： The invention belongs to the field of biomedical research involving the 1,3,4-selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.
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公开(公告)号：US07482345B2
公开(公告)日：2009-01-27
申请号：US11602782
申请日：2006-11-21
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor
IPC分类号： A61K31/53 , A61K31/5025 , A61K31/4985 , A61K31/4375 , C07D401/06 , C07D401/12 , C07D401/10 , C07D401/14 , C07D421/06 , C07D421/10 , C07D421/12 , C07D421/14 , C07D487/04 , C07D471/04
CPC分类号： C07D455/02 , C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US5723607A
公开(公告)日：1998-03-03
申请号：US792572
申请日：1997-01-30
IPC分类号： C07D475/04 , A61K31/505 , A61K31/519 , A61P35/00 , A61P43/00 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D517/04 , C07D417/06 , C07D413/06 , C07D421/06
CPC分类号： C07D513/04
摘要： The invention generally relates to compounds of the formula I, which are in equilibrium with their 4-hydroxy tautomers, and their pharmaceutically acceptable salts: ##STR1## where n is 0 to 2; A is S, CH.sub.2, O, NH or Se, and when n is 0, A is not CH.sub.2, and when n is 1, A is not CH.sub.2 or NH; X is a substituted or unsubstituted C.sub.1 -C.sub.3 alkyl, C.sub.2 -C.sub.3 alkenyl, C.sub.2 -C.sub.3 alkynyl or amino, or sulfur or oxygen; Ar is a substituted or unsubstituted monocyclic carbocycle or heterocycle, or fused or nonfused polycyclic carbocycle or heterocycle; and R.sub.1 and R.sub.2 are hydrogen or a moiety that forms together with the attached CO.sub.2 a readily hydrolyzable ester group. These compounds and their salts are useful as inhibitors of GARFT or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds, and to their synthesis.
摘要翻译： 本发明一般涉及与其4-羟基互变异构体平衡的式I化合物及其药学上可接受的盐：其中n为0至2; A是S，CH 2，O，NH或Se，当n是0时，A不是CH2，当n是1时，A不是CH2或NH; X是取代或未取代的C 1 -C 3烷基，C 2 -C 3烯基，C 2 -C 3炔基或氨基，或硫或氧; Ar是取代或未取代的单环碳环或杂环，或稠合或非稠合多环碳环或杂环; 并且R 1和R 2是氢或与所连接的CO 2一起易于水解的酯基的部分。 这些化合物及其盐可用作GARFT的抑制剂或抗增殖剂。 本发明还涉及使用诸如GARFT抑制剂或抗增殖剂的化合物的药物组合物和方法。 本发明还涉及可用作制备这些化合物的中间体的化合物及其合成。
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公开(公告)号：US4963669A
公开(公告)日：1990-10-16
申请号：US371960
申请日：1989-06-27
申请人： Michael R. Detty
发明人： Michael R. Detty
IPC分类号： C07D409/06 , C07D345/00 , C07D421/06 , C09B67/54 , G03G5/06 , G11B7/244 , G11B7/249
CPC分类号： C07D421/06 , C07D345/00 , G03G5/0637 , G11B7/244 , G11B7/249
摘要： Unsymmetrical tellurapyrylium dyes can be ungraded in purity by separating them from symmetrical analogs produced as co-products. The procedure employed for the purification comprises an oxidative halogenation, followed by a fractional crystallization, and a reduction to regenerate the tellurapyrylium dye.
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公开(公告)号：US3926971A
公开(公告)日：1975-12-16
申请号：US47227374
申请日：1974-05-22
申请人： POLAROID CORP
发明人： BORROR ALAN L , HILL RUTH LINDA , GARCIA PAULINA P
IPC分类号： C07D233/14 , C09B23/06 , C07D233/24 , C07D417/06 , C07D421/06
CPC分类号： C09B23/06 , C07D233/14
摘要： A method is disclosed for preparing 2- Beta -anilinovinyl derivatives of benzimidazolium salts, useful in the preparation of cyanine dyes and related compounds, which comprises condensing a benzimidazolium salt having a reactive methyl group with an alkyl isoformanilide in a glycol ether medium.
摘要翻译： 公开了一种用于制备苯并咪唑鎓盐的2-苯乙烯基乙烯基衍生物的方法，其可用于制备花青染料和相关化合物，其包括将具有反应性甲基的苯并咪唑盐与二醇醚介质中的烷基异丙酰苯缩合。
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