公开(公告)号：US20050165229A1

公开(公告)日：2005-07-28

申请号：US10994983

申请日：2004-11-22

申请人： Desmond Best ,  George Burton ,  Brian Gasson ,  Neal Osborne ,  Graham Walker

发明人： Desmond Best ,  George Burton ,  Brian Gasson ,  Neal Osborne ,  Graham Walker

IPC分类号： C07D463/06 ,  C07D463/16 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/26 ,  C07D501/60 ,  C07D505/06 ,  C07D505/16 ,  C07D505/18 ,  C07D501/14

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1, R2, R3, R4, X and m have meanings which are given in the description.

摘要翻译： 提供了制备根据式（II）的化合物的方法：其包括使式（III）化合物环化的步骤：其中R 1，R 2， R S，R 3，R 4，X和m具有在说明书中给出的含义。

公开(公告)号：US20240043449A1

公开(公告)日：2024-02-08

申请号：US17623252

申请日：2021-12-15

申请人： Hainan Hailing Chemipharma Corportion Ltd

发明人： Qin CAI ,  Yifeng LU ,  Xingyu CHEN

IPC分类号： C07D505/06 ,  C07D505/16

CPC分类号： C07D505/06 ,  C07D505/16

摘要： A refining method of a midbody of latamoxef sodium includes: dissolving 7β-amino-7α-methoxy-3-(5-tetrazolyl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid in dichloromethane, and then dividing into a dichloromethane layer and a water layer; extracting the dichloromethane layer, adding a NaHCO3 solution to stir, and remaining an organic layer after stratification; stirring, crystallizing and filtering the organic layer in turn, to obtain a filtrate, preparing a second powder by stirring the filtrate under conditions of a catalyst and a normal temperature; preparing a first powder by extracting the water layer, dropping the hydrochloric acid to adjust a pH value thereof, performing crystal cultivation and suction filtration after performing cooling, and then performing vacuum drying; combining the first powder and the second powder to prepare the midbody of latamoxef sodium: 7β3-amino-7α-methoxy-3-(5-tetrazolyl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid, which has a yield of 95.6-96.8% and a purity of 99.2-99.5%.

公开(公告)号：US5412094A

公开(公告)日：1995-05-02

申请号：US84651

申请日：1993-06-28

申请人： Jane G. Amos ,  Joseph M. Indelicato ,  Carol E. Pasini ,  Susan M. Reutzel

发明人： Jane G. Amos ,  Joseph M. Indelicato ,  Carol E. Pasini ,  Susan M. Reutzel

IPC分类号： C07D471/04 ,  A61K31/545 ,  C07D463/00 ,  C07D463/16 ,  C07D501/00 ,  C07D501/12 ,  C07D501/16 ,  C07D501/20 ,  C07D501/22 ,  C07D501/59 ,  C07D505/00 ,  C07D505/16 ,  C07D505/18

CPC分类号： C07D505/00 ,  C07D463/22 ,  C07D501/00

摘要： The invention provides complexes of the formula: ##STR1## wherein X is chloro, hydrogen, vinyl, or --CH.sub.3,Z is O;is 0-5;Y is phenyl or 1,4-cyclohexadien-1-yl;R.sub.1 and R.sub.2 are hydrogen or hydroxy, with the proviso that R.sub.1 and R.sub.2 are not both hydrogen andR.sub.3 is --COO.sup.-, --COO(C.sub.1 -C.sub.4 alkyl), --NO.sub.2 or ##STR2## wherein R.sub.4 is C.sub.1 -C.sub.4 alkyl.

摘要翻译： 本发明提供式：yl或-CH 3的复合物，Z是O; 是0-5; Y是苯基或1,4-环己二烯-1-基; R1和R2是氢或羟基，条件是R1和R2不同时为氢，R3为-COO-，-COO（C1-C4烷基），-NO2或