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8 条记录 (耗时 0.017 秒)

    Method for delivery of nucleic acids to cells using hypericin polyamine complexes
    4.
    发明授权
    Method for delivery of nucleic acids to cells using hypericin polyamine complexes 失效
    使用金丝桃碱多胺复合物将核酸递送至细胞的方法

    公开(公告)号：US5824654A

    公开(公告)日：1998-10-20

    申请号：US300725

    申请日：1994-09-02

    申请人： Gad Lavie ,  Alfred M. Prince

    发明人： Gad Lavie ,  Alfred M. Prince

    IPC分类号： C07C50/36 ,  C07C50/38 ,  C07C69/00 ,  A61K48/00 ,  C09B3/40 ,  C12N5/00

    CPC分类号： C07C69/00 ,  C07C50/36 ,  C07C50/38 ,  C07C2103/00

    摘要： The invention provides improved methods for delivery of nucleic acids to cells, which comprise forming ternary complexes between a hydrophobic, membrane-binding anion such as hypericin; a polycation such as polylysine; and a nucleic acid such as DNA; and contacting cells with the tenary complexes. Also provided are pharmaceutical formulations comprising these ternary complexes and a pharmaceutically acceptable carrier or diluent. The methods and compositions find use in mediating DNA uptake into cells, including gene therapy applications.

    摘要翻译： 本发明提供了将核酸递送至细胞的改进方法，其包括在疏水性的膜结合阴离子例如金丝桃素之间形成三元复合物; 聚阳离子如聚赖氨酸; 和核酸如DNA; 并使细胞与助剂络合物接触。 还提供了包含这些三元配合物和药学上可接受的载体或稀释剂的药物制剂。 该方法和组合物可用于介导DNA吸收进入细胞，包括基因治疗应用。

    Vat dyes
    6.
    发明授权
    Vat dyes 失效
    大便染料

    公开(公告)号：US5334734A

    公开(公告)日：1994-08-02

    申请号：US966404

    申请日：1992-10-26

    申请人： Matthias Niedenbrueck ,  Manfred Patsch

    发明人： Matthias Niedenbrueck ,  Manfred Patsch

    IPC分类号： C09B3/48 ,  C09B3/40 ,  C09B6/00 ,  C09B3/44

    CPC分类号： C09B3/40 ,  C09B6/00

    摘要： Vat dyes for dyeing and printing cellulose material have the formula ##STR1## where P=pyranthrone structure, A=1,4-or 1,5-anthraquinonyl, V=a violanthronyl or isoviol-anthronyl radical which may carry up to 2 chlorine or bromine atoms as substitutents, R=hydrogen, the acyl radical of an aliphatic C.sub.1 -C.sub.6 -carboxylic acid or the acyl or sulfonyl radical of an aromatic carboxylic or sulfonic acid, Hal=chlorine or bromine, m=from 0 to 3, n=from 1 to 4, and p=from 0 to 3, with the proviso that the sum m+n+p is not greater than 4.

    摘要翻译： 用于染色和印刷纤维素材料的还原染料具有式（I）其中P =吡喃酮结构，A = 1,4-或1,5-蒽醌基，V =可以携带的十六烷基或异戊醇 - 邻氨基苯甲酰基 2个氯或溴原子作为取代基，R =氢，脂族C 1 -C 6 - 羧酸的酰基或芳族羧酸或磺酸的酰基或磺酰基，Hal =氯或溴，m = 0至3 n = 1〜4，p = 0〜3，条件是m + n + p之和不大于4。

    Pigments and use thereof
    7.
    发明授权
    Pigments and use thereof 失效
    颜料及其用途

    公开(公告)号：US4986852A

    公开(公告)日：1991-01-22

    申请号：US286894

    申请日：1988-12-20

    申请人： Erwin Dietz ,  Gustav Kapaun ,  Michael Kappert ,  Frank Prokschy ,  Adolf Kroh ,  Manfred Urban

    发明人： Erwin Dietz ,  Gustav Kapaun ,  Michael Kappert ,  Frank Prokschy ,  Adolf Kroh ,  Manfred Urban

    IPC分类号： C09B1/00 ,  C09B3/14 ,  C09B3/22 ,  C09B3/40 ,  C09B5/16 ,  C09B5/20 ,  C09B5/48 ,  C09B5/62 ,  C09B19/02 ,  C09B47/04 ,  C09B47/12 ,  C09B57/04 ,  C09B67/20 ,  C09B69/00

    CPC分类号： C09B69/00 ,  C09B19/02 ,  C09B47/12 ,  C09B5/62

    摘要： Pigments of the formula I ##STR1## where A is a five- or six-membered aromatic fused or unfused heterocycle which contains one to three hetero atoms from the series consisting of nitrogen and/or oxygen and/or sulfur and which is bonded to the methylene group via a carbon atom, R.sub.1 and R.sub.2 are each hydrogen, alkyl C.sub.1 -C.sub.4, alkylene C.sub.2 or aryl, and together R.sub.1 and R.sub.2 may also be an aliphatic or aromatic ring, R.sub.3 is hydrogen, alkyl C.sub.1 -C.sub.4 hydroxylkyl C.sub.1 -C.sub.3 or alkylene C.sub.2, P is the radical of a polycyclic pigment or a radical of a mix-crystal of polycyclic pigments, and n is a number from 0.0001 to 0.2, are useful for pigmenting high molecular weight materials in the form of plastic materials, melts, spinning solutions, surface coatings, paints, printing inks, baking finishes of the class of the alkyd melamine resin or acrylic melamine resin finishes, two-component coatings based on polyisocyanate-crosslinkable acrylic resins and printing inks based on nitrocellulose.

    摘要翻译： 式I的颜料（I）其中A是五或六元芳族稠合或未稠合的杂环，其含有由氮和/或氧和/或硫组成的一系列中的一至三个杂原子，并且其是 通过碳原子与亚甲基键合，R1和R2各自为氢，烷基C1-C4，亚烷基C2或芳基，并且R1和R2一起也可以是脂族或芳香环，R3是氢，烷基C1-C4 + L，烷基C1-C3或亚烷基C2，P是多环颜料的自由基或多环颜料的混合晶体的基团，n为0.0001至0.2的数，可用于着色高分子量材料 塑料材料，熔体，纺丝溶液，表面涂料，油漆，印刷油墨，醇酸树脂三聚氰胺树脂或丙烯酸三聚氰胺树脂漆的烘烤面漆的形式，基于多异氰酸酯交联丙烯酸树脂的双组分涂料和基于 硝化纤维素。