公开(公告)号：US20230080504A1

公开(公告)日：2023-03-16

申请号：US17793207

申请日：2021-01-15

申请人： The Johns Hopkins University

发明人： Christos Georgiades ,  Shin-Jae Lee ,  Iyer Siddharth ,  Mathias Insley ,  Xingyu Jasmine Hu ,  Da In Diane Lee ,  Hai-Quan Mao

IPC分类号： A61L24/00 ,  A61L24/06

摘要： Embolization compositions and methods for controlling undesired bleeding and other treatments are provided. Preferred composition may comprise (a) a crosslinked hydrogel material; and (b) a fiber material, wherein the composition comprises a plurality of macropores; and the hydrogel material and fiber material are bonded by covalent and/or non-covalent bonds.

公开(公告)号：US11529600B2

公开(公告)日：2022-12-20

申请号：US16178188

申请日：2018-11-01

申请人： Heraeus Medical GmbH

发明人： Sebastian Vogt ,  Thomas Kluge

IPC分类号： B01F35/75 ,  A61L24/06 ,  A61B17/88 ,  B01F23/50 ,  B01F35/00 ,  B01F35/71 ,  B01F101/20

摘要： A device and method for producing a bone cement paste from a monomer liquid and a cement powder, wherein the device comprises a cartridge with a cylindrical interior chamber for mixing the parent components, whereby the interior chamber of the cartridge is closed on the front side up to a delivery opening for expelling the bone cement paste from the interior chamber, a delivery plunger which is arranged in the interior chamber of the cartridge and which is supported in a linearly movable manner in the direction of the delivery opening, the cement powder, which is arranged in the interior chamber of the cartridge between the delivery opening and the delivery plunger, a monomer receptacle with an interior chamber in which a monomer liquid container containing the monomer liquid is contained, whereby in the monomer receptacle, a conveying plunger is arranged movable in the longitudinal direction of the monomer receptacle, a compressed gas connection, whereby the conveying plunger is arranged between the monomer liquid container and the compressed gas connection or the compressed gas line in the monomer receptacle.

公开(公告)号：US11478568B2

公开(公告)日：2022-10-25

申请号：US16357709

申请日：2019-03-19

申请人： The Regents of the University of California

发明人： Joyce H. Keyak ,  Tadashi Kaneko ,  Harry B. Skinner ,  Varun Sehgal

IPC分类号： A61K51/12 ,  A61L24/00 ,  A61L24/06 ,  A61N5/10

摘要： A target tissue can be treated with a radioisotope. Some methods for treating a target tissue with a radioisotope include determining a distance between a target tissue and a surface of a matrix material to be positioned adjacent the target tissue and, based on the determined distance, determining an activity to be mixed with the matrix material to obtain a desired activity concentration. Some methods further include mixing the radioisotope with the matrix material. In some embodiments, the matrix material comprises bone cement, and the target tissue is a tumor in a bone. The radioisotope may be a beta-emitting radioisotope mixed in the cement at a concentration to form a radioactive cement.

公开(公告)号：US20220168461A1

公开(公告)日：2022-06-02

申请号：US17651509

申请日：2022-02-17

申请人： University of Virginia Patent Foundation

发明人： John C. Herr. ,  Alexander L. Klibanov ,  Kevin Simon Eisenfrats

IPC分类号： A61L24/06 ,  A61L27/52 ,  A61L27/54 ,  A61K49/22 ,  A61B8/08 ,  A61B17/12 ,  A61B17/34 ,  A61F6/22 ,  A61L24/00

摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

公开(公告)号：US11261274B2

公开(公告)日：2022-03-01

申请号：US16693077

申请日：2019-11-22

申请人： Terumo Corporation

发明人： Steve Plotkin ,  Gregory M. Cruise ,  Edward Michael Keeley ,  Renee Yu ,  Clayton Harris

IPC分类号： C08F16/06 ,  C08F20/28 ,  C08F20/56 ,  C08F20/38 ,  A61K9/14 ,  C08F220/28 ,  C08F22/38 ,  A61K31/704 ,  A61K9/00 ,  A61K9/50 ,  C08F290/06 ,  A61K47/32 ,  A61L24/00 ,  A61L24/06 ,  C08F220/38 ,  C08G65/333 ,  C08F220/10

摘要： Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US11235084B2

公开(公告)日：2022-02-01

申请号：US16033303

申请日：2018-07-12

申请人： Varian Medical Systems, Inc.

发明人： Hongxia Zeng ,  Bruce R. Forsyth ,  Hong Cao ,  Matthew R. DeWitt ,  Heidi Schwanz

IPC分类号： A61L24/02 ,  A61K9/00 ,  A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61M25/00

摘要： In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.

公开(公告)号：US20210401749A1

公开(公告)日：2021-12-30

申请号：US17468384

申请日：2021-09-07

申请人： Terumo Corporation

发明人： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris

IPC分类号： A61K9/16 ,  C08F220/56 ,  A61L24/00 ,  A61L24/06 ,  C08F220/38 ,  A61L31/04 ,  A61K9/00

摘要： Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US20210346569A1

公开(公告)日：2021-11-11

申请号：US17268441

申请日：2020-03-10

申请人： Trio Healthcare Ltd

发明人： Lloyd Pearce ,  Stewart Lee

IPC分类号： A61L24/04 ,  A61F5/448 ,  A61L24/00 ,  C08G77/20 ,  C08G77/08 ,  A61L24/08 ,  A61L24/06

摘要： A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and a moisture control particulate and permeability modifying polymer distributed within the polymer network. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-stomal skin.

公开(公告)号：US11135167B2

公开(公告)日：2021-10-05

申请号：US16516931

申请日：2019-07-19

申请人： Terumo Corporation

发明人： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris

IPC分类号： A61K9/16 ,  C08L33/14 ,  C08F220/56 ,  A61L24/00 ,  A61L24/06 ,  C08F220/38 ,  A61L31/04 ,  A61K9/00 ,  C08F222/10 ,  C08F222/38 ,  C08F222/40 ,  A61K9/19 ,  C08L33/02 ,  C08L33/26

摘要： Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US10982121B2

公开(公告)日：2021-04-20

申请号：US16386976

申请日：2019-04-17

申请人： The Florida State University Research Foundation, Inc.

发明人： Hoyong Chung

IPC分类号： C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C09J133/14 ,  C09J133/26 ,  C09J11/06 ,  A61L24/06 ,  A61L24/10 ,  C09J11/08 ,  C08K5/11

摘要： Disclosed are terpolymer adhesives comprising three different repeating domains: a catechol containing domain, a zwitterionic domain, and a crosslinking domain. In specific examples, the polymer can contain a 3,4-dihydroxy-L-phenylalanine (DOPA) segment which contains a catechol group, a poly(sulfobetaine methacrylate) (polySBMA), and poly(ethylene glycol) dimethacrylate (PEGDMA) for light crosslinking. Alternatively, a photocleavable nitrobenzyloxycarbonyl containing crosslinker can be used. The disclosed polymers can be used as biomedical adhesives, such as to prevent leakage from the sutured intestinal tissue.