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公开(公告)号：WO2020205504A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/025189
申请日：2020-03-27
摘要： The present disclosure provides methods of generating multispecific antigen-binding molecules comprising a common light chain compatible with two or more different heavy chains. The present disclosure further provides methods of identifying common light chains that are compatible with two or more different heavy chains
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公开(公告)号：WO2020033926A2
公开(公告)日：2020-02-13
申请号：PCT/US2019/046061
申请日：2019-08-09
IPC分类号： A61P35/00
摘要： The present disclosure relates to, inter alia, compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to CD277, for treating, or ameliorating one or more symptoms of cancer.
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公开(公告)号：WO2020033925A9
公开(公告)日：2020-02-13
申请号：PCT/US2019/046060
申请日：2019-08-09
摘要： The present disclosure relates to, inter alia , methods for treating, or ameliorating one or more symptoms of, cancer, with compounds ( e.g. , antibodies, or antigen-binding fragments thereof) that bind to CD277.
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公开(公告)号：WO2020033925A2
公开(公告)日：2020-02-13
申请号：PCT/US2019/046060
申请日：2019-08-09
摘要： The present disclosure relates to, inter alia , methods for treating, or ameliorating one or more symptoms of, cancer, with compounds ( e.g. , antibodies, or antigen-binding fragments thereof) that bind to CD277.
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公开(公告)号：WO2019100052A2
公开(公告)日：2019-05-23
申请号：PCT/US2018/061970
申请日：2018-11-20
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/28 , C07K16/2812 , C07K16/2815 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present disclosure relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering combinations of antibodies, or antigen- binding fragments thereof, that bind to CD137, and tumor antigen-targeting antibodies.
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公开(公告)号：WO2019089753A2
公开(公告)日：2019-05-09
申请号：PCT/US2018/058451
申请日：2018-10-31
CPC分类号： C07K16/2818 , A61K2039/507 , A61P35/00 , C07K16/2878 , C07K16/30 , C07K16/3061 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76
摘要： The present disclosure relates to combinations of antibodies, or antigen-binding fragments thereof, that bind to CD137, and PD-1 antagonists. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the combination.
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公开(公告)号：WO2020033923A1
公开(公告)日：2020-02-13
申请号：PCT/US2019/046058
申请日：2019-08-09
申请人： COMPASS THERAPEUTICS LLC , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , MOFFITT CANCER CENTER , CONEJO-GARCIA, Jose, R. , PAYNE, Kyle, Kristopher
发明人： CONEJO-GARCIA, Jose, R. , PAYNE, Kyle, Kristopher , SCHMIDT, Michael, March , MCLAUGHLIN, Brooke, T. , BOBROWICZ, Piotr
摘要： The present disclosure relates to, inter alia , methods for treating, or ameliorating one or more symptoms of, cancer, with compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to CD277.
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公开(公告)号：WO2019226617A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033255
申请日：2019-05-21
发明人： WATKINS, Jennifer , SCHMIDT, Michael March , DRAGHI, Monia , OLIPHANT, Amanda Frank , HALMOS, Sara Marie , SCHUETZ, Thomas Joseph , LAJOIE, Jason Michael , NELSON, Allison
摘要： The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells ( e.g. , cancer cells) having a low level of expression of the tumor antigen.
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公开(公告)号：WO2019028172A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/044863
申请日：2018-08-01
IPC分类号： B01D15/00 , B01D15/08 , B01D15/10 , B01D15/14 , B01D15/22 , B01J20/00 , B01J20/281 , C07K1/14 , C07K1/16 , C12M1/00 , C12N9/00 , C07K1/34 , C07K1/36
摘要： Provided herein are methods of capturing and purifying recombinant proteins from a liquid cell culture including a dual-use filtration and chromatography pod, filtration and chromatography pods, and the use of these pods.
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公开(公告)号：WO2019014328A3
公开(公告)日：2019-01-17
申请号：PCT/US2018/041612
申请日：2018-07-11
发明人： BOBROWICZ, Piotr , WIDBOOM, Paul , SCHMIDT, Michael, March , LAJOIE, Jason, M. , TIGHE, Robert, V., III , LEUNG, Cheuk, Lun , ESKIOCAK, Ugur
IPC分类号： C07K16/28
摘要： The present disclosure relates to, inter alia , compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD137 and agonize CD137, and to use of the compounds in methods for treating, or ameliorating one or more symptoms of, cancer.
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