Abstract:
Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
Abstract:
Product is conveyed as continuous streams between lane dividers (222) by metering conveyors (210-216) onto a transfer plate (32) and a transfer device (42) including first and second supports (42A, 42B). The transfer device (42) is movable between retracted and extended positions extending over a sweep conveyor (22) by securing its trailing and leading ends to flexible belts (106, 206) on opposite longitudinal sides of the sweep conveyor (22). Product is transferred from the second support (42B) to the sweep conveyor (22) and from the first support (42A) to the second support (42B) as the transfer device (42) moves from the extended position to the retracted position and is engaged by a metering bar (52B) which controls the product acceleration on the sweep conveyor (22) and by a metering bar (52A) which prevents unmetered product from tipping downstream. Sweep bars (62a, 62aa) collect the product on the sweep conveyor (22).
Abstract:
A product metering apparatus (10) includes a first product conveyance mechanism (12) conveying product in a continuous stream. A platform (42) supports product and is movable along a closed path between a loading position adjacent to the first product conveyance mechanism (12) and a transfer position adjacent to an output in the form of a second product conveyance mechanism (22) spaced from the first product conveyance mechanism (12) in the conveying direction. The platform (42) in the loading position receives the product in the continuous stream from the first product conveyance mechanism (12) and is then accelerated to a speed greater than the first product conveyance mechanism (12) creating a gap between the product supported on the platform (42) and the product remaining in the continuous stream on the first product conveyance mechanism (12). A sweep bar (52ba) is inserted into the gap and abuts with the product on the platform (42) for assisting transfer of the product on the platform (42) to the output.
Abstract:
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract:
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract:
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract:
Sulfenamide compounds of general formula (I) are disclosed wherein A, R 1, R 2 , X 1 , X 1 ’, X 2 , X 2 ’, X 3 , X 3 ’, X 4 , X 4 ’, X 5 and X 5 ’ define a variety of variables and q is 0 or 1. The compounds of the examples are galactofuranosyl and arabinofuranosyl compounds wherein the variable A is oxygen. Methods for the synthesis of compounds of general formula (I), pharmaceutical compositions them and methods of using them to treat patients suffering a microbial infection are also disclosed.
Abstract:
A rotor (25) is provided for a rotary piston pump or other rotary machine. The rotor (25) is partite, comprising an assembly of a plurality of modular elements (12). The rotor assembly (25) is covered in a coating material (63) which can be an epoxy resin. A method of making a coated rotor is also provided.
Abstract:
The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering microbial infection.
Abstract:
The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering microbial infection.