公开(公告)号：WO2012004419A3

公开(公告)日：2012-01-12

申请号：PCT/EP2011/061788

申请日：2011-07-11

Applicant: UNIVERSITÉ DE BRETAGNE OCCIDENTALE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  HAELTERS, Jean-Pierre ,  BERCHEL, Mathieu ,  COUTHON-GOURVES, Hélène ,  JAFFRES, Paul-Alain

Inventor： HAELTERS, Jean-Pierre ,  BERCHEL, Mathieu ,  COUTHON-GOURVES, Hélène ,  JAFFRES, Paul-Alain

IPC: C07F9/6558 ,  G01N21/64

Abstract: The present invention relates to fluorescent and/or targeting lipophilic compounds having the general formula (R1O) (R2O) P (O) - R3 - R4 - R5 wherein R1 and R2 are each independently a linear or branched, saturated or unsaturated C2-C24 alkyl, or a linear or branched, saturated or unsaturated C2-C24 monoalkenyl or polyalkenyl, the polyalkenyl having from 2 to 4 double bonds, or a linear or branched, saturated or unsaturated C2-C24 monoalkinyl or polyalkinyl, the polyalkinyl having from 2 to 4 triple bonds; R3 is selected from 0, S, -C(R6)2-, -CH(R7)-, -C(S) -N(R6) -, - CH ( SR7 ) - S - S - or -N(R6)- wherein R6 is a hydrogen atom or a C1 - C4 alkyl, and R7 is a C1 - C4 alkyl; R4 comprises at least one junction function and at least one linker; and R5 is at least one chemical fluorescent group or at least one targeting group. Methods for preparing said lipophilic compounds are also disclosed.

公开(公告)号：WO2012004419A2

公开(公告)日：2012-01-12

申请号：PCT/EP2011061788

申请日：2011-07-11

Applicant: UNIV BRETAGNE OCCIDENTALE ,  CENTRE NAT RECH SCIENT ,  HAELTERS JEAN-PIERRE ,  BERCHEL MATHIEU ,  COUTHON-GOURVES HELENE ,  JAFFRES PAUL-ALAIN

Inventor： HAELTERS JEAN-PIERRE ,  BERCHEL MATHIEU ,  COUTHON-GOURVES HELENE ,  JAFFRES PAUL-ALAIN

IPC: C07F9/6558 ,  G01N21/64

CPC classification number: C07F9/65586 ,  C07F9/65583 ,  C07H15/26 ,  C09B69/00

Abstract: The present invention relates to fluorescent and/or targeting lipophilic compounds having the general formula (I) and to methods for preparing said lipophilic compounds.

Abstract translation: 本发明涉及具有通式（I）的荧光和/或靶向亲脂化合物以及制备所述亲脂性化合物的方法。

公开(公告)号：WO2012045797A1

公开(公告)日：2012-04-12

申请号：PCT/EP2011/067423

申请日：2011-10-05

Applicant: UNIVERSITÉ DE BRETAGNE OCCIDENTALE ,  CNRS ,  JAFFRES, Paul-Alain ,  FRAIX, Aurore ,  MONTIER, Tristan ,  LEHN, Pierre

Inventor： JAFFRES, Paul-Alain ,  FRAIX, Aurore ,  MONTIER, Tristan ,  LEHN, Pierre

IPC: C07F9/20 ,  C07F9/24 ,  C07F9/54 ,  C07F9/72 ,  C12N15/88 ,  A61K48/00 ,  A61K31/664

CPC classification number: C07F9/2458 ,  A61K9/127 ,  A61K47/544 ,  C07F9/20 ,  C07F9/2412 ,  C07F9/5407 ,  C07F9/723 ,  C12N15/88

Abstract: The disclosure refers to cationic lipothiophosphoramidates for in vitro and in vivo gene delivery, to the use thereof for gene delivery, as well as to liposomes and lipoplexes comprising such cationic lipothiophosphoramidates and to a method for preparing such cationic lipothiophosphoramidates.

Abstract translation: 本公开涉及用于体外和体内基因递送的阳离子脂质硫代磷酰胺化物，其用于基因递送的用途，以及包含这种阳离子硫代磷酰胺化物的脂质体和脂质复合物以及制备这种阳离子型硫代磷酰胺化物的方法。