公开(公告)号：WO2023081375A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/048987

申请日：2022-11-04

Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER ,  UNIVERSITY OF CINCINNATI ,  B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： GUTMARK-LITTLE, Iris ,  GUTMARK, Ephraim ,  CAVARI, Yuval ,  KATOSHEVSKI, David

IPC: A61M16/00

Abstract: The present disclosure relates to a device for treating obstructed airways. Specifically, the present disclosure relates to a device for treating the symptoms of diseases that cause persistent airflow limitation by applying air pressure oscillations and acoustic vibrations to the airways of a patient during treatment. The device may be used in a system that allows in- home treatment under remote supervision of a physician.

公开(公告)号：WO2023049328A2

公开(公告)日：2023-03-30

申请号：PCT/US2022/044512

申请日：2022-09-23

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason Charles

IPC: G01N27/327 ,  C12Q1/26

Abstract: The present invention relates to a device for continuous sensing of at least one analyte in a test fluid that is resistant at least one of desorption of a first plurality of molecules, including a plurality of aptamers and a blocking layer, and fouling during use of the device when exposed to temperatures greater than or equal to 30°C for at least 3 days. Another aspect of the invention is a method of providing fouling resistance to an aptamer sensor device wherein the blocking layer and aptamer are resistant to at least one of desorption from the electrode and fouling during use of the aptamer sensor when exposed to temperatures greater than or equal to 30°C for at least 3 days.

公开(公告)号：WO2023023406A1

公开(公告)日：2023-02-23

申请号：PCT/US2022/041118

申请日：2022-08-22

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason ,  BELMONTE, Israel ,  WHITE, Ryan, Jeffrey

IPC: G01N27/327 ,  A61B5/01 ,  A61B5/1468 ,  C12N15/115 ,  G01K13/12 ,  G01K1/14

Abstract: A device for measuring one or more analytes in a sample fluid is provided. The device includes at least one aptamer sensor comprising a plurality of aptamers. The sensor provides a measurement of at least one of the analytes. In addition, the measurement is affected by changes in temperature ("a temperature-dependent response"). The device also includes a means to establish fluid communication between the at least one aptamer sensor and the sample fluid. Further, the device includes at least one temperature sensor and a means for correcting a measurement error due to the temperature-dependent response.

公开(公告)号：WO2023009524A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/038350

申请日：2022-07-26

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION ,  UNIVERSITY OF CINCINNATI

Inventor： LIN, Dong ,  SHI, Jing ,  PARANDOUSH, Pedram

IPC: B29C64/147 ,  B29C70/16 ,  B29C65/74 ,  C08J5/24 ,  C08J5/12

Abstract: Additive manufacturing of continuous-fiber reinforced composites. More particularly, aspects of the invention relate to additive manufacturing systems and methods for fabricating 3D parts from continuous-fiber reinforced composites such as carbon-fiber or glass-fiber pre impregnated ("pre-preg") sheets. A laser-assisted laminated object manufacturing method is used to fabricate continuous carbon fiber reinforced polymer composites (CFRPCs) using prepreg sheets with continuous-carbon fiber reinforcement. Graphene functions as a modifier between the prepreg sheets to improve the mechanical properties of the CFRPCs, specifically low porosity, high concentrations of continuous carbon fibers, and improved interfacial bonding strength. This composite architecture design, involving laminated continuous-carbon fiber reinforced prepreg sheets and graphene-modified interfaces, provides a readily scalable manufacturing method for producing 3D parts with desirable characteristics.

公开(公告)号：WO2022155426A1

公开(公告)日：2022-07-21

申请号：PCT/US2022/012446

申请日：2022-01-14

Applicant: UNIVERSITY OF CINCINNATI

Inventor： ABDALLAH, Shaaban

IPC: F03D3/06 ,  F03D3/00 ,  F03D3/02

Abstract: A savonius wind turbine including a rotational shaft and a compound blade operatively coupled to the rotational shaft is provided. The compound blade includes a primary blade portion and a secondary blade portion. The primary blade portion extends between a first end and a second end and defines a primary concave surface therebetween. The secondary blade portion is coupled to the primary blade portion between the first end and the second end. The secondary blade portion defines a secondary concave surface configured to generate a torque about the rotational shaft.

公开(公告)号：WO2022140673A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/065084

申请日：2021-12-23

Applicant: UNIVERSITY OF CINCINNATI

Inventor： ABDALLAH, Shaaban

IPC: F03D3/06 ,  F03D3/00 ,  F03D7/06

Abstract: A vertical axis wind turbine including a nozzle is provided. The nozzle includes a first airfoil and a second airfoil. The first airfoil includes a first airfoil leading edge and a first airfoil trailing edge, and the second airfoil includes a second airfoil leading edge and a second airfoil trailing edge. The nozzle defines an inlet area disposed between the first airfoil leading edge and the second airfoil leading edge and an exit area disposed between the first airfoil trailing edge and the second airfoil trailing edge, wherein the exit area is smaller than the inlet area.

公开(公告)号：WO2022132898A8

公开(公告)日：2022-06-23

申请号：PCT/US2021/063518

申请日：2021-12-15

Applicant: UNIVERSITY OF CINCINNATI ,  MAZAK CORPORATION

Inventor： AZAMFAR, Moslem ,  PANDHARE, Vibhor ,  MILLER, Marcella ,  Ll, Fei ,  Ll, Pin ,  SINGH, Jaskaran ,  DAVARI, Hossein ,  LEE, Jay ,  SANDERS, Joseph, Frank, Jr. ,  YAMAGUCHI, Keita

IPC: G05B23/02 ,  G05B19/4184 ,  G05B2219/31288 ,  G05B2219/32074 ,  G05B2219/37252 ,  G05B23/0235 ,  G05B23/0254 ,  G05B23/0283 ,  G05B23/0286

Abstract: Systems, methods, and computer program products for remaining useful life prediction. Operational data is collected from a test machine (14) until a component fails, and a training dataset generated from the operational data. The training dataset is used to define and validate a prediction model (54). Operational data received from one or more field machines (14) is provided to the prediction model (54). The prediction model (54) then predicts the remaining useful life of the component of the field machine (14). To reduce the time-to-failure of the component in the test machine (14), the component may be repeatedly subjected to an accelerated wear cycle (88). The prediction model (54) may be defined by extracting features from the training dataset. Like features may be extracted from the field dataset and provided to the prediction model (54) as part of the prediction process (100). The operational data received from the field machines (14) may be used to generate an updated prediction model (54).

公开(公告)号：WO2022072233A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/051939

申请日：2021-09-24

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason

IPC: A61B5/145 ,  G01N27/327 ,  G01N27/00 ,  A61B5/1455 ,  G01N27/333

Abstract: A device and method for continuously sensing at least one target analyte in a sample fluid. The device 100 includes a plurality of electrochemical aptamer sensors 120, 122, 124, 126; and at least one gating component 132, 134, 136 associated with at least one electrochemical aptamer sensor of the plurality of electrochemical aptamer sensors. The method includes bringing a sample fluid 190 into contact with the device, and determining or measuring a change in an electrical current associated with the at least one electrochemical aptamer sensor to (1) determine the presence of an analyte in the sample fluid, or (2) measure the amount or concentration of an analyte in the sample fluid.

公开(公告)号：WO2022067051A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051972

申请日：2021-09-24

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason

IPC: A61B5/157 ,  G01N27/27 ,  G01N27/32 ,  G01N33/483 ,  G01N33/487 ,  G01N33/50

Abstract: Devices and methods for measuring an analyte. A sensing device (10) includes a sensor (12) and a detection circuit (14) operatively coupled to the sensor. The sensor includes a working electrode (16) having an aptamer and an attached redox couple to electrochemically measure the analyte. The detection circuit is configured to apply a first scan having a first scan range to the sensor, and determine a position of a redox peak in the first scan. In response to the first scan range not matching the position of the redox peak, the detector circuit defines a second scan range that matches the position of the redox peak, and applies a second scan having the second scan range to the sensor.

公开(公告)号：WO2022067046A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051967

申请日：2021-09-24

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason

IPC: C12N15/115 ,  G01N21/01 ,  G01N21/77 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68

Abstract: A device for detecting at least one analyte in a sample fluid is provided. The device 100 includes a sensor fluid 18, a plurality of aptamers disposed in the sensor fluid, one or more aptamers of the plurality of aptamers configured to bind to an analyte, an optical source 120, and an optical detector 122 configured to detect a change in at least one optical property of the aptamers, and at least one isolation element (e.g., membrane 136) retaining the aptamer in the sensor fluid. Each of the one or more aptamers includes at least one optical tag. Each of the optical tags is configured to provide a change in at least one optical property between a first state in which the aptamer is bound to the analyte and a second state in which the aptamer is not bound to the analyte, and the first state and the second state differing in the shape of the aptamer.