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公开(公告)号：WO2023034991A1
公开(公告)日：2023-03-09
申请号：PCT/US2022/075944
申请日：2022-09-02
IPC分类号： A61K39/215 , B82Y5/00 , C07K14/165 , A61K47/02 , A61K9/14
摘要： The present disclosure provides stabilized compositions and methods relating to increasing the stability, expression activity, and amount of intact nucleic acid during storage. Such disclosure is particularly applicable to immunogenic compositions comprising mRNA and can be incorporated into compositions to reduce the severity, incidence and/or transmissability of SARS-CoV-2.
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公开(公告)号：WO2023034355A2
公开(公告)日：2023-03-09
申请号：PCT/US2022/042114
申请日：2022-08-31
发明人： RASHEED, Hayder A.
摘要： Multi-component devices for reinforcing and/or strengthening concrete members that comprise both fiber reinforced polymer materials and metallic materials. The multi-component devices may be in the form of a layered structure in which one or more smaller metallic plates are sandwiched between layers of the same or different fiber reinforced polymer sheets. Alternatively, the multi-component devices may comprise metallic and fiber reinforced polymer rods fastened together, which may be embedded within new concrete structures as major reinforcement.
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公开(公告)号：WO2023023591A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/075132
申请日：2022-08-18
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF AGRICULTURE , TRIAD NATIONAL SECURITY, LLC , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
发明人： RIEDER, Aida E. , PFLAUM, Katherine M. , DIAZ SAN SEGUNDO, Fayna C. , FISCHER, William M. , SITT, Tatjana
IPC分类号： C07K14/005 , A61K39/135 , A61P31/14 , A61K38/00
摘要： Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of and FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune response that provide protection against a broad range of serotype O FMDV strains.
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公开(公告)号：WO2022271709A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034357
申请日：2022-06-21
IPC分类号： A61B18/18
摘要： A method of ablating tissue uses a microwave ablation system with a plurality of applicators. The method includes the steps of having the applicators inserted into the tissue and located in and/or adjacent a target tissue section and having the system perform an ablation cycle by activating at least one of the applicators so that the at least one applicator emits electromagnetic radiation that is sufficiently strong to cause ablation of the target tissue section. The at least one applicator comprises a directional applicator that emits radiation to define an angular radiation pattern. The step of having the applicators inserted into the tissue includes the step of orienting the directional applicator so that the angular radiation pattern extends from the directional applicator toward the target tissue section. The method also includes the step of having the system perform a sensing cycle that includes the step of using one or more of the applicators to take a measurement associated with a dielectric property of the tissue.
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公开(公告)号：WO2022241057A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028863
申请日：2022-05-11
发明人： MCGREGOR, Duncan , HUANG, Ruiqi , WARNER JENKINS, Gabrielle , SMIDER, Vaughn , CHANG, Kyeong-Ok , MWANGI, Waithaka
IPC分类号： C07K16/10 , C07K2317/14 , C07K2317/20 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Provided herein are binding polypeptides, such as binding peptides and antibodies, against a SARS CoV-2. The binding polypeptides relate to or are based on bovine antibodies, particularly those containing an ultralong CDR3. Also provided herein are methods of treating a virus infection, such as a coronavirus infection, by delivering to a subject in need a provided binding polypeptide.
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公开(公告)号：WO2022178543A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/070739
申请日：2022-02-18
发明人： DELONG, Robert
摘要： The present disclosure provides ZnO-based compositions that stabilize mRNA and RNA as well as provide compositions and therapies to treat or prevent cancer and viral as well as microbial diseases.
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公开(公告)号：WO2022147179A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/065584
申请日：2021-12-29
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOSSMANN, Stefan H. , COVARRUBIAS-ZAMBRANO, Obdulia , EHSAN, Sumia , ESCHLIMAN, Kayla , MOTAMEDI, Massoud , NERI, Raul , COVARRUBIAS, Jose
IPC分类号： G01N33/543 , G01N33/553 , G01N33/68
摘要： Nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker, and methods for rapid diagnosis of lung conditions using specified panels of target biomarkers.
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8.发明申请
公开(公告)号：WO2022026534A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/043432
申请日：2021-07-28
IPC分类号： A61K39/215 , A61P31/14 , C07K14/165
摘要： Compositions comprising SEQ ID NO. 1 or SEQ ID NO. 2, or compositions comprising an organism having a genome that includes an insert comprising SEQ ID NO. 1 or SEQ ID NO. 2 therein are provided, together with methods for reducing the incidence of or severity of clinical signs caused by SARS-CoV-2 by administering such compositions to an animal in need thereof.
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公开(公告)号：WO2022015445A2
公开(公告)日：2022-01-20
申请号：PCT/US2021/037321
申请日：2021-06-15
IPC分类号： C01B32/182 , B82Y40/00 , B01J19/00 , C01B32/184
摘要： Apparatus and methods are provided that are capable of mass production of particulate materials, such as graphene particulates. The apparatus comprises an ignition assembly that comprises readily interchangeable electrode cassettes and that may be configured to self-clean in between the combustion cycles in which the particulate materials are generated. Methods of generating the particulate materials require low energy inputs in order to initiate the combustion reaction, which is then self-sustaining until the reactants are depleted.
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10.发明申请
公开(公告)号：WO2021222519A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/029823
申请日：2021-04-29
发明人： SHI, Yong-Cheng , SUN, Zhenhua
摘要： Compounds encapsulated with octenylsuccinic anhydride modified starch and methods of forming the encapsulated compounds are provided. Poorly water-soluble compounds, especially pharmaceuticals, are solubilized within an oil phase, which is then formed into an emulsion with an aqueous phase comprising the OSA modified starch. The resulting emulsion can be dried, such as through spray drying, for form a powder comprising the encapsulated compound.
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