公开(公告)号：WO2023076323A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/047796

申请日：2022-10-26

Applicant: DANISCO US INC.

Inventor： BEMENT, Courtney ,  CHEN, Zhongqiang ,  FAN, Xiaochun ,  MACOOL, Daniel Joseph ,  QI, Min ,  WANG, Yehong Jamie ,  XUE, Zhixiong ,  ZHU, Quinn Qun

IPC: C12N9/22 ,  C07K14/395 ,  C12N15/81 ,  C12P7/04 ,  C12P7/06

Abstract: Described are compositions and methods relating to modified yeast with disrupted RSF2 or TDA9 genes. The yeast produces a decreased amount of acetate compared to otherwise identical parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates where acetate is an undesirable end product.

公开(公告)号：WO2020069067A1

公开(公告)日：2020-04-02

申请号：PCT/US2019/053072

申请日：2019-09-26

Applicant: DANISCO US INC

Inventor： MACOOL, Daniel Joseph ,  ZHU, Quinn Qun

IPC: C12N15/81

Abstract: Described are compositions and methods relating to modified yeast that over-express the ribonucleotide reductase inhibitor, HUG1. The yeast produces an increased amount of alcohol compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates where acetate in an undesirable end product.

公开(公告)号：WO2021022097A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/044359

申请日：2020-07-30

Applicant: DANISCO US INC

Inventor： BEMENT, Courtney ,  MACOOL, Daniel Joseph ,  WANG, Yehong Jamie ,  ZHU, Quinn Qun

IPC: C12N1/18 ,  C12N9/04 ,  C12P7/06

Abstract: Described are compositions and methods relating to modified yeast that over-expresses Adh5p and harbor a heterologous phosphoketolase pathway. The yeast demonstrates increased ethanol production from glucose compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates.

公开(公告)号：WO2018176021A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/024222

申请日：2018-03-24

Applicant: DANISCO US INC

Inventor： MACOOL, Daniel Joseph ,  TEUNISSEN, Paula Johanna Maria ,  WANG, Yehong Jamie ,  YOON, Hyeryoung ,  ZHU, Quinn Qun

IPC: C12P7/06

CPC classification number: C12P7/06 ,  Y02E50/17

Abstract: Described are compositions and methods relating to the over-expression of sugar transporter-like polypeptides to reduce the amount of glycerol and acetate produced by modified yeast having an exogenous pathway that cause it to produce more ethanol and acetate than its parental yeast.

公开(公告)号：WO2020186224A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/022777

申请日：2020-03-13

Applicant: DANISCO US INC

Inventor： MACOOL, Daniel Joseph ,  ZHU, Quinn Qun

IPC: C07K14/395 ,  C12N9/04 ,  C12P7/06

Abstract: Described are compositions and methods relating to modified yeast that over-express cytochrome B2. The yeast produces an increased amount of alcohol compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates.

公开(公告)号：WO2019046043A1

公开(公告)日：2019-03-07

申请号：PCT/US2018/047259

申请日：2018-08-21

Applicant: DANISCO US INC

Inventor： MACOOL, Daniel Joseph ,  WANG, Yehong Jamie ,  TEUNISSEN, Paula Johanna Maria ,  ZHU, Quinn Qun

IPC: C07K14/415 ,  C12P7/06

Abstract: Described are compositions and methods relating to modified yeast expressing exogenous, or increased amounts, of glucose-specific, ATP-mediated transporters. The modified yeast produces an increased amount of ethanol compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates.