公开(公告)号：WO2013049218A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057352

申请日：2012-09-26

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： MIGLIAZZA, John, F. ,  LAFRANCE, Hugues ,  CHEN, Harvey, H. ,  OBA, Travis, Zenyo

IPC: A61F2/24 ,  A61M39/22 ,  A61F2/76

CPC classification number: A61F2/2412 ,  A61B17/0401 ,  A61B17/0487 ,  A61B2017/0417 ,  A61B2017/0437 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06176 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2457 ,  A61F2250/0007

Abstract: A prosthetic valve assembly and method of implanting same is disclosed. The prosthetic valve assembly includes a prosthetic valve formed by support frame and valve leaflets, with one or more tethers each having a first end secured to the support frame and the second end attached to, or configured for attachment to, to papillary muscles or other ventricular tissue. The tether is configured and positioned so as to avoid contact or other interference with movement of the valve leaflets, while at the same time providing a tethering action between the support frame and the ventricular tissue. The valve leaflets may be flexible (e.g., so-called tissue or synthetic leaflets) or mechanical.

Abstract translation: 公开了一种人造瓣膜组件及其植入方法。 假体瓣膜组件包括由支撑框架和瓣膜小叶形成的假体瓣，其中一个或多个系绳各自具有固定到支撑框架的第一端和附接到乳突肌或其它心室的第二端 组织。 系绳的构造和定位是为了避免接触或其他干扰瓣叶片的移动，同时在支撑框架和心室组织之间提供束缚作用。 瓣膜小叶可以是柔性的（例如，所谓的组织或合成小叶）或机械的。

公开(公告)号：WO2003007795A2

公开(公告)日：2003-01-30

申请号：PCT/US2002/022836

申请日：2002-07-16

Applicant: EDWARDS LIFESCIENCES CORPORATION ,  ALTERTEK/BIO INC

Inventor： LAFRANCE, Hugues ,  BERGERON, Francois ,  ROBERGE, Charles ,  GERMAIN, Lucie ,  AUGER, Francois

IPC: A61B

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2220/0075 ,  A61L27/3633 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3834 ,  A61L27/3843 ,  A61L27/507

Abstract: The tissue-engineered heart valve of the present invention is comprised of elements, such as leaflets, formed from self-supporting human engineered tissue. Such self-supporting tissue is comprised of living biological cells and extracellular matrix without the presence of nonviable scaffolding structures. Thus, the tissue-engineered heart valve of the present invention consists of totally living human tissue which could theoretically function like a native biological structure with the potential to grow, to repair and to remodel.

Abstract translation: 本发明的组织工程心脏瓣膜由自支撑人体工程化组织形成的诸如小叶的元件组成。 这种自支撑组织由活的生物细胞和细胞外基质组成，不存在不可生存的支架结构。 因此，本发明的组织工程心脏瓣膜由完全活的人体组织组成，其理论上可以像天然生物结构那样起作用，具有生长，修复和改造的潜力。