公开(公告)号：WO2018195202A1

公开(公告)日：2018-10-25

申请号：PCT/US2018/028172

申请日：2018-04-18

申请人： PELLFICURE PHARMACEUTICALS INC.

发明人： BORGSTRÖM, Per ,  BARON, Veronique, Therese

IPC分类号： A61K31/122 ,  A61K31/407

CPC分类号： A61K31/122 ,  A61K31/138 ,  A61K31/4166 ,  A61K31/4188 ,  A61K31/555 ,  A61K31/565 ,  A61K31/58 ,  A61K31/704 ,  A61K33/243 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein pharmaceutical compositions that include a compound of Formula (I) in combination with a cancer therapy treatment, such as a taxane-based chemotherapeutic or a platinum-based antineoplastic agent and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as bladder cancer or prostate cancer with such combinations of a compound of Formula (I) and a cancer therapy treatment.

公开(公告)号：WO2016040896A1

公开(公告)日：2016-03-17

申请号：PCT/US2015/049831

申请日：2015-09-11

申请人： PELLFICURE PHARMACEUTICALS, INC.

发明人： BORGSTROM, Per ,  CHRASTINA, Adrian ,  BARON, Veronique, Therese ,  ABEDINPOUR, Parisa

IPC分类号： A61K31/105 ,  A61K31/122 ,  A61P35/00

CPC分类号： C07C323/61 ,  A61K31/05 ,  A61K31/105 ,  A61K31/122 ,  A61K31/135 ,  A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/222 ,  A61K31/235 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/45 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/661 ,  C07C50/32 ,  C07C69/63 ,  C07C69/92 ,  C07C205/36 ,  C07C217/60 ,  C07C225/30 ,  C07C233/23 ,  C07C233/25 ,  C07C271/46 ,  C07C311/16 ,  C07C311/51 ,  A61K2300/00

摘要： Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

摘要翻译： 本文公开了1,4-萘醌类似物，包括一种或多种这样的1,4-萘醌类似物的药物组合物，以及治疗和/或改善与癌症相关的疾病和/或病症的方法，例如具有这样的前列腺癌 1,4-萘醌类似物。 还包括其中本文公开的1,4-萘醌类似物和激素治疗剂被提供给患有诸如癌症的患者的组合疗法。

公开(公告)号：WO2018080933A1

公开(公告)日：2018-05-03

申请号：PCT/US2017/057710

申请日：2017-10-20

申请人： PELLFICURE PHARMACEUTICALS INC.

发明人： BORGSTRÖM, Per ,  CHRASTINA, Adrian ,  BARON, Veronique, Therese

IPC分类号： A61K31/122 ,  A61P35/00

摘要： Disclosed herein are pharmaceutical compositions of 5-hydroxy-2- methylnaphthalene-l,4-dione. Also disclosed are methods of treating diseases and/or conditions associated with a cancer, such as prostate cancer with such pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-l,4-dione. The disclosed pharmaceutical compositions may provide improved dosage for oral administration to patients in the clinic. The disclosed pharmaceutical compositions may provide improved stability and/or shelf life.

摘要翻译： 本文公开了5-羟基-2-甲基萘-1,4-二酮的药物组合物。 还公开了用这样的5-羟基-2-甲基萘-1,4-二酮药物组合物治疗与癌症相关的疾病和/或病症如前列腺癌的方法。 公开的药物组合物可以为临床中的患者提供改善的口服给药剂量。 公开的药物组合物可以提供改善的稳定性和/或货架期。