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    DISULFIRAM AND METAL SALT STAGGERED ORAL DOSING REGIMEN AND STAGGERED-RELEASE ORAL UNIT DOSAGE FORMS
    4.
    发明申请
    DISULFIRAM AND METAL SALT STAGGERED ORAL DOSING REGIMEN AND STAGGERED-RELEASE ORAL UNIT DOSAGE FORMS 审中-公开
    DISFIRAMAM和金属盐交错口服给药方案和口交释放口服单位剂型

    公开(公告)号：WO2018081309A1

    公开(公告)日：2018-05-03

    申请号：PCT/US2017/058358

    申请日：2017-10-25

    申请人： CANTEX PHARMACEUTICALS, INC.

    发明人： MARCUS, Stephen

    IPC分类号： A61K31/105 ,  A61K31/16 ,  A61K31/27

    摘要： This application relates to methods and compositions for the administration of disulfiram (DSF) and heavy metals zinc and copper for the treatment and prevention of medical conditions, such as cancer. DSF and copper as well as DSF and zinc form active complexes that have been shown to be effective in the treatment of cancers. However, as described herein, DSF is incompatible with either copper or zinc for simultaneous oral administration. Included herein are improved methods and oral dosage forms comprising DSF and copper and DSF and zinc in fixed dose combinations that are configured to temporally stagger release of either DSF and copper or DSF and zinc after ingestion.

    摘要翻译： 本申请涉及用于施用双硫仑（DSF）和重金属锌和铜的方法和组合物，用于治疗和预防诸如癌症的医学病症。 DSF和铜以及DSF和锌形成活性配合物，这些活性配合物已显示在癌症治疗中有效。 然而，如本文所述，DSF与铜或锌不相容用于同时口服给药。 本文包括改进的方法和口服剂型，其包含固定剂量组合中的DSF和铜以及DSF和锌，所述固定剂量组合被配置为在摄取后在时间上错开DSF和铜或DSF和锌的释放。

    METHOD OF ANALYSIS ALLOWING AVOIDANCE OF SURGERY
    6.
    发明申请
    METHOD OF ANALYSIS ALLOWING AVOIDANCE OF SURGERY 审中-公开
    分析手段避免手术的方法

    公开(公告)号：WO2016036994A1

    公开(公告)日：2016-03-10

    申请号：PCT/US2015/048415

    申请日：2015-09-03

    申请人： MIODX

    发明人： DAHIYA, Rajvir ,  NORTHRUP, M. Allen

    IPC分类号： C12M3/00 ,  A61K31/105

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57484 ,  G06F19/20 ,  G16H50/20

    摘要： A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods allow avoidance of surgery to remove cancerous tissue.

    摘要翻译： 用于分析以下几种的基于多基因的测定法：（a）致癌基因表达; （b）肿瘤抑制基因的DNA甲基化; （c）非编码RNA表达（microRNA分析）; 和（d）公开了癌症样品中长的非编码RNA表达。 用于进行测定的测定方法和装置适用于各种癌症如肺，乳腺，结肠直肠，前列腺，肝，膀胱的诊断，预后和治疗; 肾，子宫颈，胰腺，胃，脑，口腔，子宫内膜和卵巢。 测定方法允许避免手术去除癌组织。