公开(公告)号：WO02085951A3

公开(公告)日：2003-02-06

申请号：PCT/US0149827

申请日：2001-10-19

Applicant: TECHNOLOGY RESOURCE INT CORP

Inventor： HUNG WILLIAM M ,  BERGBAUER KATRINA L ,  SU KAI C ,  WANG GUIGUI

IPC: A61K9/00 ,  A61K47/36 ,  A61L12/14 ,  C08L5/08 ,  C08B37/08 ,  A61L2/18

CPC classification number: C08L5/08 ,  A61L12/14

Abstract: The present invention is directed to a water soluble, randomly substituted partial n-, partial o- acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.

Abstract translation: 本发明涉及水溶性，随机取代的部分正 - 部分O-乙酰化壳聚糖或壳聚糖衍生物和制备水溶性，随机取代的部分N-部分O-乙酰化壳聚糖或壳聚糖衍生物的方法，包括以下步骤：将 壳聚糖或壳聚糖衍生物转化成酸性水溶液，并在相转移试剂存在下使壳聚糖或壳聚糖衍生物与乙酰化剂反应。 包括：（a）至少一种壳聚糖或壳聚糖衍生物和（b）至少一种缓冲溶液，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。

公开(公告)号：WO0105577A3

公开(公告)日：2001-03-15

申请号：PCT/US0019378

申请日：2000-07-14

Applicant: TECHNOLOGY RESOURCE INT CORP

Inventor： HUNG WILLIAM M ,  WANG GUIGUI

IPC: B29C35/08 ,  B29D11/00 ,  C08F22/10 ,  C08F290/14 ,  C08F18/14

CPC classification number: B29D11/00528 ,  B29C35/08 ,  B29C35/0888 ,  B29C2035/0827 ,  B29D11/00442 ,  B29L2011/0041 ,  C08F22/105 ,  C08F290/142

Abstract: A polymerizable composition comprising an effective amount of at least one tetrafunctional acrylate monomer. In one embodiment of the invention, a polymerizable composition is a compound comprising of at least 50 percent by weight of at least one tetrafunctional acrylate monomer, from 5 to 20 percent by weight of at least one modified bisphenol A epoxy diacrylate monomer, from 0 to 25 percent by weight of at least one acrylate monomer selected from aliphatic difunctional and polyfunctional acrylates, from 0 to 3 percent by weight of at least one UV absorber, and a source of free radicals. The lens-forming material resulted from the polymerizable composition is introduced to a lens mold with a mold cavity having a configuration conforming to the optical lens to be molded. A radiation energy source is used to cure the lens-forming material in the filled mold. The radiation energy source comprises a U-shaped UV light. The U-shaped UV light has a first arm capable of delivering UV light in a first direction and a second arm capable of delivering UV light in an opposite second direction. The first and second arms are spaced apart and substantially parallel to each other, thereby defining a space therebetween. The filled mold is placed at the center of the space therebetween the first and second arms to receive the radiations from the first and second directions for curing. The resultant lens has an inherently integrated "hard-soft-hard" structure cross-sectionally.

Abstract translation: 一种包含有效量的至少一种四官能丙烯酸酯单体的可聚合组合物。 在本发明的一个实施方案中，可聚合组合物是包含至少50重量％的至少一种四官能丙烯酸酯单体，5至20重量％的至少一种改性双酚A环氧二丙烯酸酯单体的化合物，其为0至 25重量％的至少一种选自脂族二官能和多官能丙烯酸酯的丙烯酸酯单体，0-3重量％的至少一种UV吸收剂和自由基源。 由可聚合组合物产生的透镜形成材料被引入到具有与待模制的光学透镜相符的构造的模具腔的透镜模具中。 辐射能源用于固化填充模具中的透镜形成材料。 辐射能源包括U形紫外光。 U形紫外光具有能够沿第一方向输送UV光的第一臂和能够沿相反的第二方向输送UV光的第二臂。 第一和第二臂间隔开并且基本上彼此平行，从而在它们之间形成一个空间。 填充的模具放置在第一和第二臂之间的空间的中心，以接收从第一和第二方向的辐射用于固化。 所得透镜在横截面上具有固有的“硬 - 软硬”结构。