公开(公告)号：WO2021127455A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066039

申请日：2020-12-18

Applicant: ASKLEPIOS BIOPHARMACEUTICAL, INC. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： LOW, SiewHui ,  XIAO, Xiao

IPC: A61P25/28 ,  C12N15/113 ,  C12N15/86 ,  C12N15/861 ,  C12Q1/68

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington' s disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same. Accordingly, in some aspects, the disclosure provides an isolated nucleic acid comprising or encoding the sequence set forth in any one of SEQ ID NOs: 1-22.

公开(公告)号：WO2021086841A1

公开(公告)日：2021-05-06

申请号：PCT/US2020/057510

申请日：2020-10-27

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： BROWN, Keith Andrew ,  CAO, Wenhan ,  ALSHARIF, Nourin

IPC: G01Q20/02 ,  G01Q60/24 ,  G01Q70/06

Abstract: A system includes a probe assembly, a camera, and a control system. The probe assembly includes a rigid substrate, a compliant layer provided on the rigid substrate, one or more rigid probes arranged on the compliant layer to cover at least a portion of the compliant layer, and a reflective layer covering the one or more rigid tips and uncovered portions of the compliant layer. The camera is configured to generate image data from the probe assembly. The control system is configured to receive image data from the camera and develop a topographical image of a surface of a sample, based at least in part on the received image data.

公开(公告)号：WO2020237058A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/034014

申请日：2020-05-21

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： HOLMES, Douglas P. ,  YANG, Yi ,  ZINK, Peter

IPC: B25J15/12 ,  B25J15/08 ,  B25J15/06

Abstract: A device includes a plurality of slots arranged in a pattern, a plurality of hinge portions, a pair of opposing jaw portions, and a pair of opposing actuation tabs. The pair of opposing actuation tabs are configured to move in generally opposite directions from a first position towards a second position in response to an input to aid in causing the pair of opposing jaw portions to grip an object.

公开(公告)号：WO2020014603A3

公开(公告)日：2020-01-16

申请号：PCT/US2019/041588

申请日：2019-07-12

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： MERTZ, Jerome Charles ,  BEAULIEU, Devin Robert ,  BIFANO, Thomas Gary

IPC: A61B5/00 ,  G01B9/04

Abstract: A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.

公开(公告)号：WO2020014603A2

公开(公告)日：2020-01-16

申请号：PCT/US2019/041588

申请日：2019-07-12

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： MERTZ, Jerome Charles ,  BEAULIEU, Devin Robert ,  BIFANO, Thomas Gary

IPC: G02B21/00

Abstract: A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.

公开(公告)号：WO2020014375A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041224

申请日：2019-07-10

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： MICHAS, Christos ,  CHOPRA, Anant ,  WHITE, Alice Elizabeth ,  CHEN, Christopher S.

IPC: A61M39/24 ,  F16K1/12 ,  F16K15/00

Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port and a second pressure that is less than 1 pascal and applied in a second opposing direction causes the disk to move from the second position towards the first position to inhibit fluid communication between the first port and the second port.

公开(公告)号：WO2019236888A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/035844

申请日：2019-06-06

Applicant: BOSTON MEDICAL CENTER CORPORATION

Inventor： YI, Ji ,  SONG, Weiye

IPC: A61B3/10 ,  A61B1/07 ,  A61B3/12 ,  G01B9/02 ,  G01N21/17

Abstract: A system for analyzing a tissue sample includes two wavelength-division multiplexers and a fiber coupler. The first wavelength-division multiplexer combines visible and near infrared electromagnetic radiation and directs the combined electromagnetic radiation to the fiber coupler. The fiber coupler emits a sample beam of visible and near infrared electromagnetic radiation toward a tissue sample, and a reference beam of visible and near infrared electromagnetic radiation toward a reference mirror. The sample beam reflects off the tissue sample back to the fiber coupler. The reference beam reflects off the reference mirror back to the fiber coupler. The fiber coupler combines the reflected sample and reference beams and directs the combined electromagnetic radiation to the second wavelength-division multiplexer. The second wavelength-division multiplexer sends visible electromagnetic radiation from the sample and reference beams to a first spectrometer, and near infrared electromagnetic radiation from the sample and reference beams to a second spectrometer.

公开(公告)号：WO2019200042A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/026901

申请日：2019-04-11

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  LUU, Rebeccah ,  CHOPRA, Anant

Inventor： LUU, Rebeccah ,  CHOPRA, Anant ,  CHEN, Christopher S.

IPC: C12M1/12 ,  C12M1/32 ,  C12M1/34

Abstract: Described herein are a system, device, methods and compositions related to generating 3-dimensional cardiac tissues. Also described herein are a system, device, and methods of maturing 3-dimensional cardiac tissues and maintaining their viability in culture.

公开(公告)号：WO2019143660A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/013750

申请日：2019-01-16

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： WALSH, Kenneth ,  SANO, Soichi ,  OSHIMA, Kosei

IPC: C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6886 ,  G01N33/68

Abstract: As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in one or more HSC cardiometabolic driver genes leads to pro-inflammatory signaling at multiple levels. Accordingly, provided herein are compositions, methods, and assays for modulating a HSC cardiometabolic driver gene mutation-mediated proinflammatory activity.

公开(公告)号：WO2017139659A1

公开(公告)日：2017-08-17

申请号：PCT/US2017/017491

申请日：2017-02-10

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： HELMERHORST, Eva J. ,  WEI, Guoxian ,  TIAN, Na ,  SCHUPPAN, Detlef

IPC: C12N9/52

CPC classification number: C12N9/52

Abstract: There are gluten-degrading enzymes found in Rothia species bacteria that are subtilisins that belonging to the S8A family of serine protease family. The Rothia sp. derived subtilisin-like enzymes have the conserved catalytic triad composed of a Ser, His, and Asp residues that is characteristic of the serine protease family. The Rothia subtilisin enzymes are potent at cleaving proline-containing proteins, cleaving the second peptide bond after proline in the XPX1 motif, where X is any amino acid, P is proline and X1 is a hydrophobic amino acid, e.g. the XPQ motif, where Q is glutamine. Embodiments herein provide isolated enzyme compositions and formulations comprising subtilisins gluten-degrading enzyme from a Rothia species bacteria. Also provided herein are methods of treatment of celiac disease or a related disorder, treatment of gluten-containing foodstuff, degrading and/or detoxifying gluten comprising the subtilisins gluten-degrading enzyme and/or compositions.

Abstract translation: 在Rothia种细菌中发现了属于丝氨酸蛋白酶家族的S8A家族的枯草杆菌蛋白酶的谷蛋白降解酶。 Rothia sp。 衍生的枯草杆菌蛋白酶样酶具有由丝氨酸蛋白酶家族特征的Ser，His和Asp残基组成的保守催化三联体。 Rothia枯草杆菌蛋白酶在切割含脯氨酸的蛋白质方面是有效的，其在XPX1基序中的脯氨酸之后切割第二肽键，其中X是任何氨基酸，P是脯氨酸且X1是疏水性氨基酸， 例如 XPQ基序，其中Q是谷氨酰胺。 本文的实施方式提供了分离的酶组合物和制剂，其包含来自罗氏菌属物种的枯草杆菌蛋白酶降解酶。 本文还提供了治疗乳糜泻或相关病症，治疗含麸质食物，降解和/或解毒包含枯草溶菌素麸质降解酶和/或组合物的麸质的方法。