公开(公告)号：WO1996010950A1

公开(公告)日：1996-04-18

申请号：PCT/US1995013129

申请日：1995-10-06

Applicant: CORDIS WEBSTER, INC.

Inventor： CORDIS WEBSTER, INC. ,  WEBSTER, Wilton, W., Jr.

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B18/1402 ,  A61B18/1492 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A method for treating ventricular tachycardia comprises inserting an electrode catheter into the ventricule. The ventricular wall of the heart is contacted with an ablation electrode (20) at a site where an aberrant electrical pathway is located. Radiofrequency is delivered through the ablation electrode (20) to the tissue for a time sufficient to confirm the site of the aberrant electrical pathway and to preheat the tissue. Short high voltage electrical pulses are then delivered to the tissue through the same electrode (20) to thereby form a non-conductive lesion.

Abstract translation: 一种治疗室性心动过速的方法包括将电极导管插入心室。 心脏的心室壁与位于异常电路径位置的消融电极（20）接触。 将射频通过消融电极（20）传送到组织足以确认异常电通路的位置并预热组织的时间。 短的高电压电脉冲然后通过相同的电极（20）传送到组织，从而形成非导电损伤。

公开(公告)号：WO1995020349A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001123

申请日：1995-01-27

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  PANESCU, Dorin ,  SWANSON, David, K.

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/05 ,  A61B5/0538 ,  A61B5/6858

Abstract: This invention is systems and methods to examine heart tissue morphology using three or more spaced apart electrodes (38), at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical currents (64) through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods (206) also sense the timing of local depolarization events in the tissue in which impedance is sensed, and derive therefrom the propagation velocities of the sensed depolarization events.

Abstract translation: 本发明是使用三个或更多个间隔开的电极（38）检查心脏组织形态的系统和方法，其中至少两个电极位于心脏内与心内膜组织接触。 系统和方法通过位于选择的电极对之间的心脏组织的区域传输电流（64），每对中的至少一个电极位于心脏内。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。 系统和方法（206）还感测在其中感测阻抗的组织中的局部去极化事件的定时，并从其导出感测的去极化事件的传播速度。

公开(公告)号：WO1995010979A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011740

申请日：1994-10-14

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  KUCK, Karl-Heinz ,  THOMPSON, Russell, B.

IPC: A61B05/0452

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2018/1497 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046

Abstract: A multiple electrode array (18) senses electrical events in heart tissue at different orientations in a localized region. First, second, and third electrode elements (60, 62, 64) are spaced apart along different axes. The electrodes (60, 62, 64) are electrically isolated from each other. The spaced apart and electrically isolated electrodes (60, 62, 64) sense multiple bipolar signals measured along the different axes. The electrode array (18) can, without changing position, continuously record multiple electrical events at different relative orientations within a localized area. The spacing and orientation of electrodes on the array (18) permit the physician to detect a small volume signal (like one associated with an accessory pathway), and to differentiate it from nearby large volume signals (like those associated with atrial and ventricular potentials).

Abstract translation: 多电极阵列（18）以局部区域中的不同取向感测心脏组织中的电事件。 第一，第二和第三电极元件（60,62,64）沿着不同的轴线间隔开。 电极（60,62,64）彼此电隔离。 间隔开和电隔离的电极（60,62,64）感测沿着不同轴测量的多个双极信号。 电极阵列（18）可以在不改变位置的情况下连续记录局部区域内的不同相对取向的多个电气事件。 阵列（18）上的电极的间距和取向允许医生检测小体积信号（如与附件通路相关联的信号），并将其与附近的大体积信号（如与心房和心室电位相关的信号）区分开来， 。

公开(公告)号：WO1995010975A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011618

申请日：1994-10-14

Applicant: WASHINGTON RESEARCH FOUNDATION

Inventor： WASHINGTON RESEARCH FOUNDATION ,  EMERY, Michael, J.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/6855 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2562/0209 ,  A61B2562/043

Abstract: The present invention provides devices and methods for in vivo and ex vivo monitoring and normalizing of physiological parameters, such as pH, sodium, potassium, calcium, pCO2, and pO2. The in vivo devices include an elongated catheter (12) with a physiological sensor (18) mounted thereon and having a port (16) through which a physiological solution, from a device (42) for normalizing the parameter, is infused into the body. In use, the value of the parameter is measured, compared to a reference value to obtain a difference. The device for normalizing the value of the parameter then acts to reduce the difference. The ex vivo device functions in a similar manner, except that the blood is removed from the body and passed through the lumen of a flow through sensor containing a physiological sensor (18). Additionally, multiple sensors may be used and/or multiple parameters may be measured.

Abstract translation: 本发明提供用于体内和离体监测和标准化生理参数如pH，钠，钾，钙，pCO 2和pO 2的装置和方法。 体内装置包括具有安装在其上的生理传感器（18）的细长导管（12），并且具有端口（16），来自用于使参数标准化的装置（42）的生理溶液通过该口输入体内。 在使用中，测量参数的值，与参考值进行比较以获得差异。 用于标准化参数值的设备然后用于减小差异。 离体装置以类似的方式起作用，除了将血液从身体移除并通过含有生理传感器（18）的流过传感器的内腔。 另外，可以使用多个传感器和/或可以测量多个参数。

公开(公告)号：WO1994022366A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003768

申请日：1994-04-06

Applicant: CARDIAC PATHWAYS CORPORATION

Inventor： CARDIAC PATHWAYS CORPORATION ,  IMRAN, Mir, A. ,  POMERANZ, Mark, L. ,  ZADNO-AZIZI, Gholam-Reza

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/6858 ,  A61B18/00 ,  A61B18/08 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0091 ,  A61B2018/1467 ,  A61B2562/0209 ,  A61B2562/043 ,  C08L2201/12

Abstract: Apparatus for mapping a wall of a heart forming a chamber in the heart comprising a guiding catheter (21) having a lumen extending therethrough and a mapping catheter (51) having a shaft (52) that is slidably mounted in the lumen of the guiding catheter. A basket assembly (61) is provided and is comprised of a plurality of circumferentially spaced-apart longitudinally extending arms (62) having proximal and distal extremities (63, 64). The proximal extremities of the arms are secured to the distal extremity of the shaft of the mapping catheter. Each of the arms includes a member formed of a material having a recoverable strain in excess of 1 % and had an outwardly bowed shape memory. At least one electrode (68) is provided on each of the arms. Conductors (69) connected to the electrodes are carried by the arms.

Abstract translation: 用于映射在心脏中形成腔室的心壁的装置，包括具有延伸穿过其中的内腔的引导导管（21）和具有可滑动地安装在引导导管的内腔中的轴（52）的映射导管（51） 。 篮组件（61）设置并且包括具有近端和远端（63,64）的多个周向间隔开的纵向延伸臂（62）。 臂的近端被固定到映射导管的轴的远端。 每个臂包括由具有超过1％的可恢复应变并且具有向外弯曲形状记忆的材料形成的构件。 至少一个电极（68）设置在每个臂上。 连接到电极的导体（69）由臂承载。

公开(公告)号：WO1993020750A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003289

申请日：1993-04-08

Applicant: CARDIORHYTHM

Inventor： CARDIORHYTHM ,  JARACZWESKI, Richard ,  WEST, Scott

IPC: A61B05/042

CPC classification number: A61B5/0422 ,  A61B5/6855 ,  A61B2562/0209 ,  A61B2562/043 ,  A61M25/0133 ,  A61M25/0141 ,  A61M2025/0161

Abstract: An intracardiac electrical potential reference catheter (10) includes a proximal shaft section (14) in a distal flexible tip section (12). The flexible tip section shaped in a geometry suitable for performing intracardiac mapping and includes a plurality of electrodes (24, 26, 28, 30, 34) axially spaced-apart thereon. The shaft section is formed from a polymeric material (41) and includes a reinforcement layer, typically a stainless steel braid (44). The flexible tip section is also formed from a polymeric material (31) and is free from any braided reinforcement. A core wire (70) is attached to a proximal housing (22) on the catheter at one end and to a distal electrode tip (34) at the other end. In this way, the torque is transmitted along the length of the catheter by both the reinforced shaft and separately by the core wire.

Abstract translation: 心内电位参考导管（10）包括位于远侧柔性末端部分（12）中的近侧轴部分（14）。 所述柔性尖端部分成形为适于执行心脏内映射的几何形状，并且包括在其上轴向间隔开的多个电极（24,26,28,30,34）。 轴部由聚合物材料（41）形成，并且包括加强层，通常为不锈钢编织物（44）。 柔性末端部分也由聚合物材料（31）形成，并且没有任何编织加固件。 芯线（70）在一端附接到导管上的近端壳体（22）并且在另一端附接到远端电极尖端（34）。 以这种方式，扭矩通过加强轴和芯线单独地沿着导管的长度传递。

公开(公告)号：WO1993015654A1

公开(公告)日：1993-08-19

申请号：PCT/US1993001199

申请日：1993-02-09

Applicant: INTERFLO MEDICAL, INC.

Inventor： INTERFLO MEDICAL, INC. ,  MCKOWN, Russell, C. ,  QUINN, Michael, D. ,  YELDERMAN, Mark, L.

IPC: A61B05/027

CPC classification number: A61B5/6855 ,  A61B5/028 ,  A61B5/6857 ,  A61B2018/00166 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2562/08 ,  G05D23/2401

Abstract: A system for keeping the surface temperature of an electric resistance-type heater element in a thermodilution catheter within safe physiological limits includes, in the preferred embodiment, a heater element core temperature monitor, a monitor for monitoring the power that is supplied to the heater element, and a surface temperature calculator for calculating the surface temperature of the heater element based on the core temperature, supplied power, and information representing the characteristics of the particular catheter under anticipated clinical conditions. A second aspect of the invention involves a system for determining the supply of power to the heater element based on the core temperature of the heater element. A third aspect of the invention involves a system readiness test for determining, in vivo, that the thermodilution catheter system is properly calibrated before the system is operational. Methods of operation for each of the above-referenced aspects of the invention are also disclosed.

Abstract translation: 用于将电阻型加热器元件的表面温度保持在热量稀释导管内的安全生理学限制的系统在优选实施例中包括加热器元件芯温度监视器，用于监视供应给加热器元件的功率的监视器 以及表面温度计算器，用于在预期的临床条件下基于核心温度，供应的功率和表示特定导管的特征的信息来计算加热器元件的表面温度。 本发明的第二方面涉及一种用于基于加热器元件的核心温度确定对加热器元件的供电的系统。 本发明的第三方面涉及用于在体内确定在系统运行之前对热稀释导管系统进行适当校准的系统准备测试。 还公开了用于本发明的每个上述参考方面的操作方法。