公开(公告)号：WO2013061281A1

公开(公告)日：2013-05-02

申请号：PCT/IB2012/055893

申请日：2012-10-26

Applicant: HEMODYNAMIX MEDICAL SYSTEMS INC.

Inventor： CARON, Eric ,  BILODEAU, Luc ,  PAQUETTE, Michel

IPC: A61B5/0215 ,  A61B5/01 ,  B81B7/02 ,  G01F1/66 ,  G01F1/68 ,  G01L11/02

CPC classification number: A61B5/02154 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6855 ,  A61B8/488 ,  G01F1/6884 ,  G01K11/32 ,  G01K13/02 ,  G01P5/10 ,  G06F19/3418 ,  G16H40/63

Abstract: An apparatus (100), control system (150) and methods are provided for directly measuring a pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, e.g. enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors (10) is arranged along a length of the distal end portion (101), for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors (10), and optionally, a flow sensor (20), are incorporated into a distal end portion (101) having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers (11), to an optical coupler (112) at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

Abstract translation: 提供了一种设备（100），控制系统（150）和方法，用于直接测量压力梯度，即通过实时压力测量，具体应用于原位测量主动脉瓣和其他心脏瓣膜的跨瓣血压梯度 ，使用微创技术。 该装置采用多传感器组件的形式，例如， 封闭在微导管或可导向的导丝内，并且包括沿着远端部分（101）的长度布置的多个光学压力传感器（10），用于在每个传感器位置同时测量压力。 例如，四个MOMS光学压力传感器（10）和任选的流量传感器（20）被并入直径为0.89mm或更小，优选为0.46mm或更小的远端部分（101）中。 有利的是，所有传感器经由相应的光纤（11）被光学耦合到多传感器设备的近端处的光耦合器（112），而不需要电连接。

公开(公告)号：WO2012177586A1

公开(公告)日：2012-12-27

申请号：PCT/US2012/043055

申请日：2012-06-19

Applicant: SHIH, Hue-teh

Inventor： SHIH, Hue-teh

IPC: A61M25/00

CPC classification number: A61B18/1492 ,  A61B5/0422 ,  A61B5/6855 ,  A61B5/6857 ,  A61B17/2202 ,  A61B2017/00867 ,  A61B2018/00273 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61M25/0158 ,  A61M2025/0161

Abstract: Systems and methods for steering catheters to facilitate advancing the catheters through the body, wherein the catheters employ multiple steering stages, each of which can move in multiple planes. The steering stages are independently controlled to enable them to form complex shapes. In one embodiment, the steerable catheter includes an elongated catheter body (200) with the steering stages (210, 220) incorporated into the distal end of the catheter. The steering stages may incorporate multiple memory wires (330-333) and corresponding heating elements (340-343) that control the temperatures of the memory wires and consequently control the shapes of the wires and the steering stages in which they are embedded. The catheter may be any type of catheter (e.g., a lumen catheter) and may include features that enable the catheter to perform functions such as delivering therapies (e.g., ablation) to target tissues within the body.

Abstract translation: 用于转向导管以便于使导管穿过身体的系统和方法，其中导管采用多个转向级，每个转向级可在多个平面中移动。 转向级独立控制，使其形成复杂的形状。 在一个实施例中，可转向导管包括细长的导管主体（200），其中转向级（210,220）并入导管的远端。 转向级可以包括多个存储器线（330-333）和对应的加热元件（340-343），其控制存储器线的温度并因此控制线和它们嵌入其中的转向级的形状。 导管可以是任何类型的导管（例如，内腔导管），并且可以包括能够导管执行功能的特征，例如将治疗（例如，消融）递送到体内的靶组织。

公开(公告)号：WO2012158263A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/031014

申请日：2012-03-28

Applicant: ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. ,  TEGG, Troy T. ,  SENN, Andrew ,  KAUPHUSMAN, James V. ,  BEDNAREK, Michael C.

Inventor： TEGG, Troy T. ,  SENN, Andrew ,  KAUPHUSMAN, James V. ,  BEDNAREK, Michael C.

IPC: A61B8/00

CPC classification number: A61M25/01 ,  A61B1/0052 ,  A61B5/0422 ,  A61B5/062 ,  A61B5/065 ,  A61B5/6855 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4466 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0212 ,  A61B2034/2051 ,  A61M25/0136 ,  A61M37/0092 ,  A61N7/02

Abstract: Catheter ultrasound systems including a sheath, a handle (2), a sheath lumen, and an ultrasound catheter (196) disposed within the lumen of the sheath with ultrasound elements (220) capable of visualizing anatomical regions. The handle (2) allowing the ultrasound catheter (196) to rotate with respect to the sheath using a rotation adjustment knob within the handle or alternatively a separate manipulation handle attached to the proximal end of the ultrasound catheter (196). The sheath, ultrasound catheter (196), or both may also include one or more electrodes or other location sensor for both orienting the ultrasound element (220) as well as for diagnostic purposes.

Abstract translation: 导管超声系统包括护套，手柄（2），鞘腔和设置在护套的内腔内的超声波导管（196），超声波元件（220）能够可视化解剖区域。 手柄（2）允许超声波导管（196）相对于护套旋转，使用手柄内的旋转调节旋钮或附加到超声波导管（196）的近端的单独操作手柄。 护套，超声导管（196）或两者还可以包括用于定向超声波元件（220）以及用于诊断目的的一个或多个电极或其它位置传感器。

公开(公告)号：WO2009032363A1

公开(公告)日：2009-03-12

申请号：PCT/US2008/058963

申请日：2008-03-31

Applicant: BAXANO, INC. ,  SCHMITZ, Gregory, P. ,  WALLCE, Michael, P. ,  BLEICH, Jeffery, L. ,  MILLER, Eric, C.

Inventor： SCHMITZ, Gregory, P. ,  WALLCE, Michael, P. ,  BLEICH, Jeffery, L. ,  MILLER, Eric, C.

IPC: A61B5/0488

CPC classification number: A61B5/0488 ,  A61B5/1104 ,  A61B5/4041 ,  A61B5/4504 ,  A61B5/4893 ,  A61B5/6855 ,  A61B2562/0209 ,  A61B2562/0261 ,  A61B2562/043 ,  A61B2562/046

Abstract: Described herein are devices, systems and methods for determining if a nerve is nearby a device or a region of a device. In general, a device for determining if a nerve is nearby a device includes an elongate body having an outer surface with one or more bipole pairs arranged on the outer surface. Bipole pairs may also be referred to as tight bipoles. The bipole pairs may be arranged as a bipole network, and may include a cathode and an anode that are spaced relatively close together to form a limited broadcast field. In general, the broadcast filed is a controlled or "tight" broadcast field that extends from the bipole pair(s). Methods of using these devices and system are also described.

Abstract translation: 本文描述了用于确定神经是否在设备或设备的区域附近的装置，系统和方法。 通常，用于确定神经是否在设备附近的装置包括具有外表面的细长主体，所述外表面具有布置在外表面上的一个或多个双极对。 双极对也可以称为紧双极。 双极对可以被布置为双极网络，并且可以包括相对靠近在一起而形成有限的广播场的阴极和阳极。 通常，广播文件是从双极对延伸的受控或“紧密”的广播字段。 还描述了使用这些装置和系统的方法。

公开(公告)号：WO2008083082A1

公开(公告)日：2008-07-10

申请号：PCT/US2007/088581

申请日：2007-12-21

Applicant: CARDIAC PACEMAKERS, INC. ,  SHUROS, Allan, Charles ,  KANE, Michael, John

Inventor： SHUROS, Allan, Charles ,  KANE, Michael, John

IPC: A61B5/026 ,  A61B5/00 ,  A61B5/07

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/6855 ,  A61B2562/0261

Abstract: Disclosed herein, among other things, are intravascular flow sensors and related methods. In an embodiment, there is an intravascular flow sensor including a strain gauge and a positioning element configured to be expandable from a first diameter to a second diameter. In an embodiment, there is an intravascular flow sensor including a deflection member configured to be positioned within a lumen defined by a tissue wall, the deflection member including a flexible shaft and a shaft tip; and a positioning member configured to prevent -the shaft tip from contacting the tissue wall. In an embodiment, there is an implantable medical device including a pulse generator and an intravascular flow sensor in communication with the pulse generator, the intravascular flow sensor including a strain gauge. Other aspects and embodiments are provided herein.

Abstract translation: 本文中公开的是血管内流量传感器和相关方法。 在一个实施例中，存在包括应变计和定位元件的血管内流量传感器，所述定位元件被构造成可从第一直径扩展到第二直径。 在一个实施例中，存在血管内流量传感器，其包括被配置为定位在由组织壁限定的腔内的偏转构件，所述偏转构件包括柔性轴和轴尖; 以及定位构件，其构造成防止所述轴尖端接触所述组织壁。 在一个实施例中，存在可植入医疗装置，其包括与脉冲发生器连通的脉冲发生器和血管内流量传感器，血管内流量传感器包括应变计。 本文提供了其它方面和实施例。

公开(公告)号：WO2007139479A1

公开(公告)日：2007-12-06

申请号：PCT/SE2007/000528

申请日：2007-05-31

Applicant: HLB CATHETER AB ,  KÄLLBÄCK, Bengt ,  HULT, Anders ,  BRODIN, Lars-Åke ,  ELMQVIST, Håkan

Inventor： KÄLLBÄCK, Bengt ,  HULT, Anders ,  BRODIN, Lars-Åke ,  ELMQVIST, Håkan

IPC: A61N1/05 ,  A61M25/00 ,  B29C53/52 ,  H05K1/00

CPC classification number: A61N1/05 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/6855 ,  A61B2562/125 ,  A61N1/056 ,  A61N2001/0585 ,  B29C53/52 ,  B29C53/84 ,  B29L2031/7542 ,  H05K1/0272 ,  H05K1/0274 ,  H05K1/0289 ,  H05K1/118 ,  H05K1/189 ,  H05K2201/051 ,  H05K2201/09072 ,  H05K2203/0126

Abstract: A device (100) for invasive use, comprising a support member (101) comprising a flexible material. The support member (101) comprises a layer of a conductive line or pattern (117) thereon. The support member (101) is formed into an elongated tube shape, and the inside of the support member (101) can be sealed from the outside of the support member (101). An electrically conductive line or pattern (117) extends on the inside of the tube shaped support member (101), and the support member (101) may comprise a sensing, stimulating and/or processing element (111, 113, 200, 201). Furthermore, there is described a manufacturing method for the device (100), a system where the device (100) is a part of the system and the use of the device (100) for invasive use.

Abstract translation: 一种用于侵入式使用的装置（100），包括包括柔性材料的支撑构件（101）。 支撑构件（101）包括其上的导电线或图案（117）的层。 支撑构件（101）形成为细长的管状，并且支撑构件（101）的内部可以从支撑构件（101）的外部密封。 导电线或图案（117）在管状支撑构件（101）的内部延伸，并且支撑构件（101）可以包括感测，刺激和/或处理元件（111,113,200,2201） 。 此外，描述了用于装置（100）的制造方法，其中装置（100）是系统的一部分的系统以及用于侵入性使用的装置（100）的使用。

公开(公告)号：WO2007050683A3

公开(公告)日：2007-07-12

申请号：PCT/US2006041630

申请日：2006-10-23

Applicant: SPECTRASCIENCE INC ,  SIEVERT CHET ,  WILSON SCOTT ,  ZIMMERMAN RON ,  POKORNEY JIM

Inventor： SIEVERT CHET ,  WILSON SCOTT ,  ZIMMERMAN RON ,  POKORNEY JIM

IPC: A61B18/18

CPC classification number: A61B5/0084 ,  A61B5/0075 ,  A61B5/6855 ,  A61B18/1492 ,  A61B2017/00061 ,  A61B2018/2238

Abstract: A catheter has an elongated catheter shaft adapted for introduction into a body passageway of a patient. At least one optical fiber extends through the catheter shaft. The optical fiber has a distal end positioned at or near a distal end of the catheter for illuminating tissue and receiving light energy from tissue at the location of the distal end of the tip. A distal region of the catheter includes a deformed portion having a crest offset from a longitudinal axis of the catheter shaft. A distal tip of the optical fiber is positioned at the crest to increases the likelihood of the distal tip contacting tissue of a wall of the body passageway.

Abstract translation: 导管具有适于引入患者身体通道的细长导管轴。 至少一根光纤延伸穿过导管轴。 光纤具有定位在导管的远端处或附近的远端，用于照射组织并且从末端的远端的位置处的组织接收光能。 导管的远侧区域包括具有从导管轴的纵向轴线偏移的顶部的变形部分。 光纤的远侧末端位于顶部以增加远侧末端接触身体通道的壁的组织的可能性。

公开(公告)号：WO99005971A1

公开(公告)日：1999-02-11

申请号：PCT/US1998/015484

申请日：1998-07-27

IPC: A61B5/042 ,  A61B5/06 ,  A61B8/08 ,  A61B8/12 ,  A61B18/14

CPC classification number: A61B5/06 ,  A61B5/0422 ,  A61B5/6855 ,  A61B5/6856 ,  A61B5/6858 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/445 ,  A61B8/543 ,  A61B18/1492 ,  A61B2017/00106 ,  A61B2018/00065 ,  A61B2018/00113 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2218/002 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N2007/0078

Abstract: The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.

Abstract translation: 本发明是使用一个或多个超声参考导管使用三角测量原理在患者心脏内建立固定的三维坐标系的装置定位系统。 坐标系在视频监视器上以三维图形化地表示，并且帮助临床医生引导其他具有超声波换能器的医疗设备，通过身体到需要进行临床程序的位置。 在根据本发明的系统的一个实施例中，该系统用于心脏中，以帮助医师将用于测量电活动的导管和用于将心脏组织的选定区域烧蚀的消融导管映射到心脏内的期望位置。

公开(公告)号：WO1996025095A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002090

申请日：1996-02-14

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  PANESCU, Dorin

IPC: A61B05/0402

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6858 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056 ,  A61N1/3702 ,  A61N1/403

Abstract: Analog or digital systems (10) and methods generate a composite signal derived from a biological event in a time sequential fashion. A first set of signals derived from a biological event using a first group of sensors (20) during a first time interval is input. A second set of signals derived from the biological event during a second time interval sequentially after the first time interval using a second group of sensors (36) is input. The second group of sensors has at least one common sensor that is part of the first group and other sensors that are not part of the first group. The first and second sets of signals are time aligned using signals sensed by the at least one common sensor, thereby generating the composite signal. The time alignment is done by shifting the first and second sets of signals either with or without computing a time difference between them.

Abstract translation: 模拟或数字系统（10）和方法以时间顺序的方式产生从生物事件导出的复合信号。 输入在第一时间间隔期间使用第一组传感器（20）从生物事件导出的第一组信号。 输入使用第二组传感器（36）在第一时间间隔之后的第二时间间隔期间从生物事件导出的第二组信号。 第二组传感器具有至少一个共同的传感器，其是第一组的一部分和不是第一组的一部分的其它传感器。 使用由至少一个公共传感器感测的信号来对第一和第二组信号进行时间对准，从而产生复合信号。 时间对准是通过移动第一和第二组信号来完成的，无论是否计算它们之间的时间差。

公开(公告)号：WO1995029629A1

公开(公告)日：1995-11-09

申请号：PCT/IB1995000184

申请日：1995-03-20

Applicant: BIOMEDICAL SENSORS, LTD.

Inventor： BIOMEDICAL SENSORS, LTD. ,  SINGER, Mervyn

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/1473 ,  A61B5/6853 ,  A61B5/6855 ,  A61M25/10

Abstract: An apparatus for the determination and continuous monitoring of bladder epithelial oxygen (pb02) which comprises, in combination, an introductory catheter (1) with an inflatable placement cuff (4) and an oxygen sensor, wherein the sensor is completely accommodated within the catheter (1) when not in use and, when the apparatus is placed within a patient's bladder, the sensor is adapted to be deployed so that the distal end (7) of the sensor passes through an open port (3) in the distal wall of the catheter (1) and extends beyond the tip (2) of the catheter (1) to rest against the wall of the bladder; and a method for the continuous monitoring of pb02 using such apparatus.

Abstract translation: 一种用于确定和连续监测膀胱上皮氧（pb02）的装置，其组合包括具有可充气放置袖带（4）和氧传感器的导入导管（1），其中所述传感器完全容纳在导管内 1）当不使用时，并且当将装置放置在患者的膀胱内时，传感器适于被展开，使得传感器的远端（7）穿过位于病人膀胱的远侧壁中的开口（3） 导管（1）并延伸超过导管（1）的尖端（2）以抵靠膀胱的壁; 以及使用这样的装置连续监测pb02的方法。